1. Foreword

   • Osamu Hayaishi
   • Yoshihiro Urade

   EditorialNotes 28 July 2016 Pages: S1 - S1

2. Recent Progress in Sleep Research — Biological, Clinical and Social Impact

   • Osamu Hayaishi

   Recent Progress in Sleep Research — Biological, Clinical and Social Impact 28 July 2016 Pages: S2 - S2

3. Developmental situation of hypnotics in Japan

   • Mitsukuni Murasaki

   Recent Progress in Sleep Research — Biological, Clinical and Social Impact 28 July 2016 Pages: S3 - S3

4. Development of sleep disturbance detector

   • Yoshiro Sugita
   • Akira Mikami
   • Yoshihisa Shigedo

   Recent Progress in Sleep Research — Biological, Clinical and Social Impact 28 July 2016 Pages: S4 - S4

5. Poor compensatory function for sleep loss in delayed sleep phase syndrome and non-24-hour sleep-wake syndrome

   • Makoto Uchiyama
   • Yuichi Kamei
   • Kiyohisa Takahashi

   Recent Progress in Sleep Research — Biological, Clinical and Social Impact 28 July 2016 Pages: S5 - S6

6. How much further should we go to develop and establish sleep medicine in Japan? (Through a comparison between Japan and the US)

   • Naoko Tachibana

   Recent Progress in Sleep Research — Biological, Clinical and Social Impact 28 July 2016 Pages: S7 - S8

7. Recent progress in sleep research: Biological, clinical and public health impact

   • Carl E. Hunt

   Recent Progress in Sleep Research — Biological, Clinical and Social Impact 28 July 2016 Pages: S9 - S10

8. Hypocretin/dopamine interaction in sleep-related motor function

   • Seiji Nishino

   Recent Progress in Sleep Research — Biological, Clinical and Social Impact 28 July 2016 Pages: S11 - S12

9. Behavioral state instability in orexin knockout mice

   • T. E. Scammell
   • A. Crocker
   • T. Mochizuki

   Recent Progress in Sleep Research — Biological, Clinical and Social Impact 28 July 2016 Pages: S13 - S14

10. Integrating hypocretins/orexins into an overall neural circuit model of sleep-wake regulation

    • Peter Shiromani
    • Carlos Blanco-Centurion
    • Frank Desarnaud

    Recent Progress in Sleep Research — Biological, Clinical and Social Impact 28 July 2016 Pages: S15 - S16

11. Molecular mechanism of prostaglandin D₂-mediated non-REM sleep homeostasis studied by gene-knockout mice

    • Naomi Eguchi
    • Wei-Min Qu
    • Osamu Hayaishi

    Recent Progress in Sleep Research — Biological, Clinical and Social Impact 28 July 2016 Pages: S17 - S18

12. Adenosine A_2A receptors and neuroadaptation: Possible implications in sleep-wake physiology

    • Jiang-Fan Chen
    • Michael A. Schwarzschild

    Recent Progress in Sleep Research — Biological, Clinical and Social Impact 28 July 2016 Pages: S19 - S20

13. Histaminergic role in sleep-wake cycle of orexin, adenosine, and prostaglandin E₂ and D₂

    • Z.-L. Huang
    • W.-M. Qu
    • O. Hayaishi

    Recent Progress in Sleep Research — Biological, Clinical and Social Impact 28 July 2016 Pages: S21 - S22

14. In vitro study of the sleep promoting neurons from the ventrolateral preoptic nucleus

    • P. H. Luppi
    • T. Gallopin
    • P. Fort

    Recent Progress in Sleep Research — Biological, Clinical and Social Impact 28 July 2016 Pages: S23 - S24

15. Role of the lateral hypothalamus in sleep

    • D. Gerashchenko
    • P. J. Shiromani

    Recent Progress in Sleep Research — Biological, Clinical and Social Impact 28 July 2016 Pages: S25 - S26

16. Links between the suprachiasmatic nucleus and sleep-wake centers: Finding pathways

    • Kazue Semba

    Recent Progress in Sleep Research — Biological, Clinical and Social Impact 28 July 2016 Pages: S27 - S29

17. Striato-rhinencephalic activation during paradoxical sleep as revealed by c-fos expression

    • Michel Jouvet

    Recent Progress in Sleep Research — Biological, Clinical and Social Impact 28 July 2016 Pages: S30 - S30

18. cDNA array studies of natural and pharmacologically induced sleep

    • Thomas S. Kilduff
    • Teresa L. Steininger
    • Akira Terao

    Recent Progress in Sleep Research — Biological, Clinical and Social Impact 28 July 2016 Pages: S31 - S33

19. Genetics of delta and theta activities during sleep: Deficiency in short-chain fatty acid β-oxidation affects theta oscillations during sleep

    • Mehdi Tafti
    • Paul Franken

    Recent Progress in Sleep Research — Biological, Clinical and Social Impact 28 July 2016 Pages: S34 - S35

20. Towards identification of genes underlying sleep homeostasis

    • Paul Franken

    Recent Progress in Sleep Research — Biological, Clinical and Social Impact 28 July 2016 Pages: S36 - S37

21. Clock genes and light-induced resetting of circadian clock: Dichotomy in mammalian circadian center

    • Yasufumi Shigeyoshi

    Recent Progress in Sleep Research — Biological, Clinical and Social Impact 28 July 2016 Pages: S38 - S39

22. Integration mechanism of molecular rhythm in biological clock

    • Hitoshi Okamura

    Recent Progress in Sleep Research — Biological, Clinical and Social Impact 28 July 2016 Pages: S40 - S41

23. Effect of PLCβ4 in the thalamus on the EEG in REM sleep

    • Tohru Yoshioka

    Recent Progress in Sleep Research — Biological, Clinical and Social Impact 28 July 2016 Pages: S42 - S43

24. Expression of the poly-glutamine-ataxin-3 transgene causes loss of orexin expression: A rat model of narcolepsy

    • Carsten T. Beuckmann
    • Christopher M. Sinton
    • Masashi Yanagisawa

    Recent Progress in Sleep Research — Biological, Clinical and Social Impact 28 July 2016 Pages: S44 - S44

25. Evening naps and delayed night-time sleep schedule typically found in Japanese adolescents is closely related with their daytime malfunctioning

    • Kazuhiko Fukuda
    • Kaneyoshi Ishihara

    Recent Progress in Sleep Research — Biological, Clinical and Social Impact 28 July 2016 Pages: S45 - S46

26. Inhibition of orexin-induced wakefulness by pyrilamine, an H1 receptor antagonist

    • Kazuki Honda
    • Akihiro Yamanaka
    • Takeshi Sakurai

    Recent Progress in Sleep Research — Biological, Clinical and Social Impact 28 July 2016 Pages: S47 - S47

27. Circadian rhythms in Ca²⁺ release from ryanodine-sensitive Ca²⁺ stores in suprachiasmatic nucleus neurons

    • Masayuki Ikeda

    Recent Progress in Sleep Research — Biological, Clinical and Social Impact 28 July 2016 Pages: S48 - S48

28. Genetic approach to sleep-disordered breathing

    • Hiroshi Kadotani
    • M. Taniguchi
    • Y. Inoue

    Recent Progress in Sleep Research — Biological, Clinical and Social Impact 28 July 2016 Pages: S49 - S49

29. Hypocretin levels in patients with primary hypersomnia and OSAS, and secondary hypersomnia due to hypocretin deficiency

    • M. Abe
    • T. Kanbayashi
    • T. Shimizu

    Recent Progress in Sleep Research — Biological, Clinical and Social Impact 28 July 2016 Pages: S50 - S50

30. Hormone replacement therapy and menopausal sleep disorders: A trial study in an animal model

    • Mayumi Kimura

    Recent Progress in Sleep Research — Biological, Clinical and Social Impact 28 July 2016 Pages: S51 - S52

31. Activity of the neurons in the perifornical hypothalamic area during sleep and waking in comparison with those in the brainstem noradrenergic or cholinergic neurons

    • Y. Koyama
    • K. Takahashi
    • Y. Kayama

    Recent Progress in Sleep Research — Biological, Clinical and Social Impact 28 July 2016 Pages: S53 - S53

32. Simulating transmeridian flights

    • Mitsuyuki Nakao
    • Keisuke Yamamoto
    • Mitsuaki Yamamoto

    Recent Progress in Sleep Research — Biological, Clinical and Social Impact 28 July 2016 Pages: S54 - S54

33. Adenosine A_2A receptor deficiency attenuates the somnogenic effect of prostaglandin D₂

    • Wei-Min Qu
    • Zhi-Li Huang
    • Osamu Hayaishi

    Recent Progress in Sleep Research — Biological, Clinical and Social Impact 28 July 2016 Pages: S55 - S55

34. Lack of rebound of non-rapid eye movement sleep after sleep deprivation in adenosine A_2A receptor knockout mice

    • Mie Sakata
    • Naomi Eguchi
    • Osamu Hayaishi

    Recent Progress in Sleep Research — Biological, Clinical and Social Impact 28 July 2016 Pages: S56 - S56

35. Role of hypothalamic orexin neurons in the regulation of arousal according to energy balance

    • Akihiro Yamanaka
    • Carsten T. Beuckmann
    • Takeshi Sakurai

    Recent Progress in Sleep Research — Biological, Clinical and Social Impact 28 July 2016 Pages: S57 - S57

36. Accuracy evaluation of sleep-wake stage analysis with SleepSign Ver2.0

    • Yujiro Taguchi
    • Shima Hando
    • Yoshihiro Urade

    Recent Progress in Sleep Research — Biological, Clinical and Social Impact 28 July 2016 Pages: S58 - S58

37. Prostaglandin D synthase: From X-ray crystallography to gene manipulation

    • Yoshihiro Urade
    • Naomi Eguchi
    • Osamu Hayishi

    Recent Progress in Sleep Research — Biological, Clinical and Social Impact 28 July 2016 Pages: S59 - S59

38. Regulation of orexin neurons by the monoaminergic and cholinergic systems

    • Akihiro Yamanaka
    • Yo Muraki
    • Takeshi Sakurai

    Recent Progress in Sleep Research — Biological, Clinical and Social Impact 28 July 2016 Pages: S60 - S60

39. Recent progress in sleep research: Medical and social impact

    • Osamu Hayaishi

    Recent Progress in Sleep Research — Medical and Social Impact 28 July 2016 Pages: S61 - S61

40. Medical and public health impact of sleep problems

    • Carl E. Hunt

    Recent Progress in Sleep Research — Medical and Social Impact 28 July 2016 Pages: S62 - S63

41. Sleep hygiene and medicine in Japan

    • Kiyohisa Takahashi

    Recent Progress in Sleep Research — Medical and Social Impact 28 July 2016 Pages: S64 - S64

42. Sleep disorders: Is hypocretin involved in sleep, wakefulness, narcolepsy, and/or cataplexy?

    • Michael H. Chase

    Recent Progress in Sleep Research — Medical and Social Impact 28 July 2016 Pages: S65 - S65

43. Insomnia and its pharmacotherapy

    • Mitsukuni Murasaki

    Recent Progress in Sleep Research — Medical and Social Impact 28 July 2016 Pages: S66 - S66

44. Sleep mechanisms

    • Alexander A. Borbély

    Recent Progress in Sleep Research — Medical and Social Impact 28 July 2016 Pages: S67 - S68

45. Science of sleep

    • Yoshihiro Urade

    Recent Progress in Sleep Research — Medical and Social Impact 28 July 2016 Pages: S69 - S69

46. Dream and consciousness

    • Michel Jouvet

    Recent Progress in Sleep Research — Medical and Social Impact 28 July 2016 Pages: S70 - S70