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2. Treat functional constipation in children with conventional options first and consider alternatives if needed

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3. Nails blue? Don’t be sad, the cause may be discoverable

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4. Prescribe colchicine with care and be aware of colchicine drug interactions

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5. First reports of adverse drug reactions

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6. Addressing the opioid epidemic in Pakistan: urgent need for opioid stewardship and comprehensive solutions

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