1. Hans J. Müller-Eberhard 1928–1998

   • Peter A. Miescher

   Legacy Pages: 1 - 1

2. Rheumatoid arthritis: introduction

   • M. Feldmann
   • R. N. Maini

   OriginalPaper Pages: 3 - 4

3. Heterogeneity of rheumatoid arthritis: from phenotypes to genotypes

   • Cornelia M. Weyand
   • Piotr A. Klimiuk
   • Jörg J. Goronzy

   OriginalPaper Pages: 5 - 22

4. Evaluating candidate autoantigens in rheumatoid arthritis

   • Andrew P. Cope
   • Grete Sonderstrup

   OriginalPaper Pages: 23 - 39

5. Molecular mechanism of immune response, synovial proliferation and apoptosis in rheumatoid arthritis

   • T. Hasunuma
   • T. Kato
   • K. Nishioka

   OriginalPaper Pages: 41 - 52

6. Antigen-presenting cells in rheumatoid arthritis

   • Ranjeny Thomas

   OriginalPaper Pages: 53 - 72

7. Angiogenesis in rheumatoid arthritis: implications for future therapeutic strategies

   • Ewa M. Paleolog
   • Roy A. Fava

   OriginalPaper Pages: 73 - 94

8. Adhesion molecules in rheumatoid arthritis

   • Nancy Oppenheimer-Marks
   • Peter E. Lipsky

   OriginalPaper Pages: 95 - 114

9. Chemokines in rheumatoid arthritis

   • Zoltan Szekanec
   • Robert M. Strieter
   • Alisa E. Koch

   OriginalPaper Pages: 115 - 132

10. Role of pro-inflammatory cytokines in rheumatoid arthritis

    • Fionula M. Brennan
    • Ravinder N. Maini
    • Marc Feldmann

    OriginalPaper Pages: 133 - 147

11. Joint inflammation and cartilage destruction may occur uncoupled

    • Wim B. van den Berg

    OriginalPaper Pages: 149 - 164

12. Combination therapy in mice: what can we learn that may be useful for understanding rheumatoid arthritis?

    • Richard O. Williams

    OriginalPaper Pages: 165 - 180

13. Modulating the Th1/Th2 balance in inflammatory arthritis

    • B. Müller
    • U. Gimsa
    • Z. Yin

    OriginalPaper Pages: 181 - 196

14. Gene therapy for rheumatoid arthritis

    • Paul D. Robbins
    • Christopher H. Evans
    • Yuti Chernajovsky

    OriginalPaper Pages: 197 - 209

15. Biological insights from clinical trials with anti-TNF therapy

    • Marc Feldmann
    • Peter Charles
    • Ravinder N. Maini

    OriginalPaper Pages: 211 - 228

16. Treatment of rheumatoid arthritis with IL-1 inhibitors

    • Cem Gabay
    • William P. Arend

    OriginalPaper Pages: 229 - 246

17. Therapy of rheumatoid arthritis by blocking IL-6 signal transduction with a humanized anti-IL-6 receptor antibody

    • Kazuyuki Yoshizaki
    • Norihiro Nishimoto
    • Tadamitsu Kishimoto

    OriginalPaper Pages: 247 - 259

18. Anti-CD4 monoclonal antibodies in rheumatoid arthritis

    • Ernest H. S. Choy
    • Gabrielle H. Kingsley
    • Gabriel S. Panayi

    OriginalPaper Pages: 261 - 273

19. Cytokine therapy in rheumatoid arthritis

    • Josef Hermann
    • Marita Walmsley
    • Fionula M. Brennan

    OriginalPaper Pages: 275 - 288

20. Oral tolerance and the treatment of rheumatoid arthritis

    • Howard L. Weiner
    • Yoshinori Komagata

    OriginalPaper Pages: 289 - 308

21. Drug-combination therapy of rheumatoid arthritis

    • P. A. Miescher
    • H. Favre
    • P. Tamagnini

    OriginalPaper Pages: 309 - 318