1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine (VNP40101M): I. Direct inhibition of O6-alkylguanine-DNA alkyltransferase (AGT) by electrophilic species generated by decomposition P. G. PenkethK. ShyamA. C. Sartorelli Original Article 24 December 2003 Pages: 279 - 287
1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine (VNP40101M): II. Role of O6-alkylguanine-DNA alkyltransferase in cytotoxicity R. P. BaumannK. ShyamA. C. Sartorelli Original Article 17 December 2003 Pages: 288 - 295
The efficacy of the combination therapy of 5-fluorouracil, cisplatin and leucovorin for hepatocellular carcinoma and its predictable factors Takayuki KogureYoshiyuki UenoToru Shimosegawa Original Article 20 December 2003 Pages: 296 - 304
Comparison of four modulators of drug metabolism as protectants against the hepatotoxicity of the novel antitumor drug yondelis (ET-743) in the female rat and in hepatocytes in vitro Sarah DonaldRichard D. VerschoyleAndreas J. Gescher Original Article 11 December 2003 Pages: 305 - 312
Pharmacokinetics and cellular uptake of imatinib and its main metabolite CGP74588 Philipp le CoutreKarl-Anton KreuzerEberhard Schleyer Original Article 05 December 2003 Pages: 313 - 323
The development of targeted chemotherapy for CNS lymphoma—a pilot study of the IDARAM regimen P. MoretonG. J. MorganJ. A. Child Original Article 24 December 2003 Pages: 324 - 328
Systemic and tumor disposition of platinum after administration of cisplatin or STEALTH liposomal-cisplatin formulations (SPI-077 and SPI-077 B103) in a preclinical tumor model of melanoma William C. ZamboniAnne C. GervaisJulie L. Eiseman Original Article 12 December 2003 Pages: 329 - 336
Phase II clinical trial of parenteral hydroxyurea in combination with fluorouracil, interferon and filgrastim in the treatment of advanced pancreatic, gastric and neuroendocrine tumors Andreas KaubischRon KaleyaScott Wadler Original Article 24 December 2003 Pages: 337 - 340
A Cancer Research (UK) randomized phase II study of idoxifene in patients with locally advanced/metastatic breast cancer resistant to tamoxifen S. R. D. JohnstonL. A. GumbrellR. C. Coombes Original Article 13 January 2004 Pages: 341 - 348
Characterization of tetrandrine, a potent inhibitor of P-glycoprotein-mediated multidrug resistance Liwu FuYongju LiangQichao Pan Original Article 10 December 2003 Pages: 349 - 356
Phase I trial of the antifolate ZD9331 in combination with cisplatin in patients with refractory solid malignancies Joshua H. BilenkerJames P. StevensonPeter J. O’Dwyer Clinical Trial Report 13 January 2004 Pages: 357 - 360
