New approaches to drug discovery and development: a mechanism-based approach to pharmaceutical research and its application to BNP7787, a novel chemoprotective agent Frederick H. HausheerHarry KochatJeffrey D. Saxe OriginalPaper 18 June 2003 Pages: 3 - 15
Structural development of synthetic retinoids and thalidomide-related molecules Yuichi Hashimoto OriginalPaper 18 June 2003 Pages: 16 - 23
Survival-signaling pathway as a promising target for cancer chemotherapy Naoya FujitaTakashi Tsuruo OriginalPaper 18 June 2003 Pages: 24 - 28
Anticancer drug development at the US National Cancer Institute Chris H. Takimoto OriginalPaper 18 June 2003 Pages: 29 - 33
Clinical significance of the expression of estrogen receptors α and β for endocrine therapy of breast cancer Hirotaka IwaseZhenhan ZhangShunzo Kobayashi OriginalPaper 19 June 2003 Pages: 34 - 38
New approaches to the endocrine prevention and treatment of breast cancer Anthony HowellSacha J. HowellD. Gareth Evans OriginalPaper 18 June 2003 Pages: 39 - 44
The opportunities and challenges of personalized genome-based molecular therapies for cancer: targets, technologies, and molecular chaperones Paul Workman OriginalPaper 18 June 2003 Pages: 45 - 56
Pharmacogenomic applications in clinical drug development Nicholas C. Dracopoli OriginalPaper 18 June 2003 Pages: 57 - 60
Novel direct and indirect cyclin-dependent kinase modulators for the prevention and treatment of human neoplasms Adrian M. Senderowicz OriginalPaper 18 June 2003 Pages: 61 - 73
Panel of human cancer cell lines provides valuable database for drug discovery and bioinformatics Takao Yamori OriginalPaper 18 June 2003 Pages: 74 - 79
Thymidylate synthase inhibitors as anticancer agents: from bench to bedside Edward ChuMarc A. CallenderJohn C. Schmitz OriginalPaper 18 June 2003 Pages: 80 - 89
Monoclonal antibodies for the treatment of hematologic malignancies: clinical trials in Japan Kensei Tobinai OriginalPaper 18 June 2003 Pages: 90 - 96
Strategy for the development of novel anticancer drugs Nagahiro SaijoTomohide TamuraKazuto Nishio OriginalPaper 18 June 2003 Pages: 97 - 101