Current status of the molecular mechanisms of anticancer drug-induced apoptosis Ryungsa KimKazuaki TanabeTetsuya Toge Review Pages: 343 - 352
Phase I pharmacodynamic study of time and sequence dependency of hydroxyurea in combination with gemcitabine: a California Cancer Consortium Trial Yun YenWarren ChowJames H. Doroshow Original Article Pages: 353 - 359
Pharmacokinetics and organ distribution of N-methanocarbathymidine, a novel thymidine analog, in mice bearing tumors transduced with the herpes simplex thymidine kinase gene Roy NoyZvi Ben-ZviRiad Agbaria Original Article Pages: 360 - 366
Establishment and characterization of a mouse FM3A cell mutant resistant to topoisomerase II-inhibitor NC-190 Kazunori SamataTakehiro YamagishiKazuei Igarashi Original Article Pages: 367 - 372
The effect of malignant effusions on methotrexate disposition Jing LiPeter Gwilt Original article Pages: 373 - 382
High-dose, single-agent irinotecan as first-line therapy in the treatment of metastatic colorectal cancer M. Ychou J. Raoul Y. Merrouche Original Article Pages: 383 - 391
Toxicity of intracranial and intraperitoneal O6-benzyl guanine in combination with BCNU delivered locally in a mouse model Michael GuarnieriAnn Biser-RohrbaughBenjamin S. Carson Original Article Pages: 392 - 396
Ras-mediated activation of ERK by cisplatin induces cell death independently of p53 in osteosarcoma and neuroblastoma cell lines Willi WoessmannXinbin ChenArndt Borkhardt Original Article Pages: 397 - 404
Tumour cell uptake of the metastasis inhibitor ruthenium complex NAMI-A and its in vitro effects on KB cells Fabiana FrausinMoreno CocchiettoGianni Sava Original Article Pages: 405 - 411
Angiostatin potentiates cyclophosphamide treatment of metastatic disease Helena J. MauceriSaraswathy SeetharamRalph R. Weichselbaum Original Article Pages: 412 - 418
A mathematical model of in vivo methotrexate accumulation in acute lymphoblastic leukemia John PanettaYuri YanishevskiMary V. Relling Original article Pages: 419 - 428
Carboplatin hypersensitivity presenting as coronary vasospasm – a case report Martin R. ChasenIftikar O. Ebrahim Short Communication Pages: 429 - 431