1. Antibody-directed enzyme prodrug therapy: pharmacokinetics and plasma levels of prodrug and drug in a phase I clinical trial

   • Janet Martin
   • Stephen M. Stribbling
   • C. J. Springer

   ORIGINAL ARTICLE Pages: 189 - 201

2. Pharmacokinetics and pharmacodynamics of MX2 hydrochloride in patients with advanced malignant disease

   • Denis J. Morgan
   • John S. Hill
   • Michael D. Green

   ORIGINAL ARTICLE Pages: 202 - 208

3. Human tumor models in the severe combined immune deficient (scid) mouse

   • Gillian D. Paine-Murrieta
   • Charles W. Taylor
   • Evan M. Hersh

   ORIGINAL ARTICLE Pages: 209 - 214

4. Multienzyme-mediated stable and transient multidrug resistance and collateral sensitivity induced by xenobiotics

   • Ganaganur K. Rekha
   • N. E. Sladek

   ORIGINAL ARTICLE Pages: 215 - 224

5. Phase II study of pyrazoloacridine in patients with advanced colorectal carcinoma

   • Mark M. Zalupski
   • Philip A. Philip
   • Anthony F. Shields

   ORIGINAL ARTICLE Pages: 225 - 227

6. Tubulin from paclitaxel-resistant cells as a probe for novel antimicrotubule agents

   • Dan L. Sackett
   • Paraskevi Giannakakou
   • Antonio Fojo

   ORIGINAL ARTICLE Pages: 228 - 232

7. Dose intensity of uracil and tegafur in postoperative chemotherapy for patients with poorly differentiated gastric cancer

   • Keizo Sugimachi
   • Yoshihiko Maehara
   • Masao Tomita

   ORIGINAL ARTICLE Pages: 233 - 238

8. Antiestrogenic activities of alternate-substituted polychlorinated dibenzofurans in MCF-7 human breast cancer cells

   • Gulan Sun
   • S. Safe

   ORIGINAL ARTICLE Pages: 239 - 244

9. Resistance to paclitaxel mediated by P-glycoprotein can be modulated by changes in the schedule of administration

   • Zhirong Zhan
   • Stefania Scala
   • T. Fojo

   ORIGINAL ARTICLE Pages: 245 - 250

10. Disposition of conjugate-bound and free doxorubicin in tumor-bearing mice following administration of a BR96-doxorubicin immunoconjugate (BMS 182248)

    • Kathleen W. Mosure
    • Arris J. Henderson
    • J. O. Knipe

    ORIGINAL ARTICLE Pages: 251 - 258

11. Disposition of irinotecan and SN-38 following oral and intravenous irinotecan dosing in mice

    • Clinton F. Stewart
    • William C. Zamboni
    • Peter J. Houghton

    ORIGINAL ARTICLE Pages: 259 - 265

12. Effect of single and multiple administration of an O 6-benzylguanine/temozolomide combination: an evaluation in a human melanoma xenograft model

    • Stephen R. Wedge
    • Julia K. Porteous
    • E. S. Newlands

    ORIGINAL ARTICLE Pages: 266 - 272

13. Feasibility trial of high-dose 7-day continuous-infusion ifosfamide given on an outpatient basis

    • J. Bellmunt
    • N. Eres
    • J. Baselga

    CLINICAL TRIAL REPORT Pages: 273 - 276