Pharmacokinetics of the hypoxic cell cytotoxic agent tirapazamine and its major bioreductive metabolites in mice and humans: retrospective analysis of a pharmacokinetically guided dose-escalation strategy in a phase I trial Martin A. GrahamSuresh SenanPaul Workman ORIGINAL ARTICLE Pages: 1 - 10
Quantitative relationship between pharmacokinetics of unchanged cisplatin and nephrotoxicity in rats: importance of area under the concentration-time curve (AUC) as the major toxicodynamic determinant in vivo Naomi NagaiH. Ogata ORIGINAL ARTICLE Pages: 11 - 18
Arterial occlusion in patients with peripheral vascular disease treated with platinum-based regimens for lung cancer John MathewsRakesh GoelD. J. Stewart ORIGINAL ARTICLE Pages: 19 - 22
Cellular uptake and antitumor activity of the new anthracycline analog DA-125 in human cancer cell lines Kyoung-Hwa LimHun-Sik KimJ.-G. Park ORIGINAL ARTICLE Pages: 23 - 30
Overexpression of thioredoxin does not confer resistance to cisplatin in transfected human ovarian and colon cancer cell lines Manabu YamadaAkihiro TomidaT. Tsuruo ORIGINAL ARTICLE Pages: 31 - 37
Effect of glutathione depletion on the cytotoxicity of cisplatin and iproplatin in a human melanoma cell line L. PendyalaR. PerezP. J. Creaven ORIGINAL ARTICLE Pages: 38 - 44
Pharmacokinetics of trofosfamide and its dechloroethylated metabolites G. HempelSebastian KrümpelmannJoachim Boos ORIGINAL ARTICLE Pages: 45 - 50
Combination chemotherapy involving orally administered etoposide and JM-216 in murine tumor models William C. Rose ORIGINAL ARTICLE Pages: 51 - 56
Quantification of 4-hydroxyifosfamide in plasma of ifosfamide-treated mice R. F. StruckD. M. McCainK. H. Tillery ORIGINAL ARTICLE Pages: 57 - 59
Depletion of p185erbB2, Raf-1 and mutant p53 proteins by geldanamycin derivatives correlates with antiproliferative activity Won G. AnRodney C. SchnurM. V. Blagosklonny ORIGINAL ARTICLE Pages: 60 - 64
Characterization of cellular accumulation and toxicity of illudin S in sensitive and nonsensitive tumor cells M. J. KelnerTrevor C. McMorrisRaymond Taetle ORIGINAL ARTICLE Pages: 65 - 71
Thiotepa and etoposide treatment of recurrent malignant gliomas: phase I study Casilda BalmacedaM. R. FetellCharles Hesdorffer ORIGINAL ARTICLE Pages: 72 - 74
Glutathione content but not gamma glutamyl cysteine synthetase mRNA expression predicts cisplatin resistance in head and neck cancer cell lines Kenneth NewkirkJoseph HeffernKevin J. Cullen ORIGINAL ARTICLE Pages: 75 - 80
An investigation of the antitumour activity and biodistribution of polymeric micellar paclitaxel Xichen ZhangHelen M. BurtW. L. Hunter ORIGINAL ARTICLE Pages: 81 - 86
Host distribution and response to antitumor alkylating agents of EMT-6 tumor cells from subcutaneous tumor implants Sylvia A. HoldenYasunori EmiB. A. Teicher ORIGINAL ARTICLE Pages: 87 - 93
Establishment of a cisplatin-resistant gastric carcinoma cell line OCUM-2M/DDP Atsunori NittaYong-Suk ChungMichio Sowa SHORT COMMUNICATION Pages: 94 - 97