1. Therapeutic response and potential pitfalls in phase I clinical trials of anticancer agents conducted in Japan

   • Kuniaki Itoh
   • Yasutsuna Sasaki
   • Kaoru Abe

   Original Articles Pages: 451 - 454

2. Disposition of leucovorin and its metabolites in the plasma, intestinal epithelium, and intraperitoneal L1210 cells of methotrexate-pretreated mice

   • Marlene A. Bunni
   • Francis M. Sirotnak
   • David G. Priest

   Original Articles Pages: 455 - 458

3. Quercetin potentiates the effect of adriamycin in a multidrug-resistant MCF-7 human breast-cancer cell line: P-glycoprotein as a possible target

   • G. Scambia
   • F. O. Ranelletti
   • S. Mancuso

   Original Articles Pages: 459 - 464

4. Plasma pharmacokinetics and tissue distribution of paclitaxel in CD₂F₁ mice

   • Julie L. Eiseman
   • Natalie D. Eddington
   • Merrill J. Egorin

   Original Articles Pages: 465 - 471

5. Relationship of cell survival, drug dose, and drug uptake after 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine treatment

   • Keiichi Fujiwara
   • Larry W. Daniel
   • C. Anne Wallen

   Original Articles Pages: 472 - 476

6. Mammary carcinoma regression induced by perillyl alcohol, a hydroxylated analog of limonene

   • Jill D. Haag
   • Michael N. Gould

   Original Articles Pages: 477 - 483

7. Enhancement of the cytotoxicity of cisplatin by the cholecystokinin antagonist MK-329 in a human pancreatic cancer cell line

   • Ramin Jamshidipour
   • Eudes B. Pinho
   • Stephen B. Howell

   Original Articles Pages: 484 - 490

8. Intracellular metabolism of 5-methyltetrahydrofolate and 5-formyltetrahydrofolate in a human breast-cancer cell line

   • Donna M. Voeller
   • Carmen J. Allegra

   Original Articles Pages: 491 - 496

9. Influence of tumor size on the main drug-metabolizing enzyme systems in mouse colon adenocarcinoma Co38

   • Liliane Massaad
   • Guy G. Chabot
   • Alain Gouyette

   Original Articles Pages: 497 - 502

10. In vivo inhibition of etoposide-mediated apoptosis, toxicity, and antitumor effect by the topoisomerase II-uncoupling anthracycline aclarubicin

    • Bente Holm
    • Peter Buhl Jensen
    • Heine Høi Hansen

    Original Articles Pages: 503 - 508

11. Sequential therapy with dacarbazine and carmustine: a phase I study

    • R. Brian Mitchell
    • M. Eileen Dolan
    • Richard L. Schilsky

    Original Articles Pages: 509 - 514

12. CAI: effects on cytotoxic therapies in vitro and in vivo

    • Beverly A. Teicher
    • Sylvia A. Holden
    • David Northey

    Original Articles Pages: 515 - 521

13. Modulation of all-trans retinoic acid pharmacokinetics by liarozole

    • Vincent A. Miller
    • James R. Rigas
    • Raymond P. Warrell Jr.

    Original Articles Pages: 522 - 526

14. Interaction of liposome-associated all-trans-retinoic acid with squamous carcinoma cells

    • Ranjani Parthasarathy
    • Peter G. Sacks
    • Kapil Mehta

    Original Articles Pages: 527 - 534

15. Letter to the editors

    • Rosemarie Mick
    • Mark J. Ratain
    • Elizabeth Poplin

    Letter to the Editors/Reply Pages: 535 - 536