1. Novel pyrrolo[2,3-d]pyrimidine antifolate TNP-351: cytotoxic effect on methotrexate-resistant CCRF-CEM cells and inhibition of transformylases of de novo purine biosynthesis

   • Fumio Itoh
   • Orsola Russello
   • G. Peter Beardsley

   Original Articles Pages: 273 - 279

2. The quinoline-3-carboxamide Linomide inhibits angiogenesis in vivo

   • P. Borgström
   • I. P. Torres Filho
   • B. Hartley-Asp

   Original Articles Pages: 280 - 286

3. Antitumor effects of IST-622, a novel synthetic derivative of chartreusin, against murine and human tumor lines following oral administration

   • Tazuko Tashiro
   • Kenji Kon
   • Shigeru Tsukagoshi

   Original Articles Pages: 287 - 292

4. Comparison of 5-fluorouracil anabolite levels after intravenous bolus and continuous infusion

   • Theodore A. Stein
   • Beverly Bailey
   • Gerard P. Burns

   Original Articles Pages: 293 - 296

5. Evaluation of methotrexate tissue exposure by in situ microdialysis in a rat model

   • Per O. Ekstrøm
   • Anders Andersen
   • Lars Slørdal

   Original Articles Pages: 297 - 301

6. Thermal enhancement of drug uptake and DNA adducts as a possible mechanism for the effect of sequencing hyperthermia on cisplatin-induced cytotoxicity in L1210 cells

   • Shinji Ohno
   • Zahid H. Siddik
   • Joan M. C. Bull

   Original Articles Pages: 302 - 306

7. Chemomodulation of drugs involved in multidrug resistance in chronic lymphatic leukemia of the B-cell type

   • A. Reichle
   • H. Diddens
   • R. Andreesen

   Original Articles Pages: 307 - 316

8. Preclinical pharmacology of bizelesin, a potent bifunctional analog of the DNA-binding antibiotic CC-1065

   • Denise L. Walker
   • Joel M. Reid
   • Matthew M. Ames

   Original Articles Pages: 317 - 322

9. Effects of intralesional injection of cisplatin dissolved in urografin and lipiodol on Ehrlich ascites tumor and normal tissues of CD-1 mice

   • Jose E. Landrito
   • Koji Yoshiga
   • Kazuaki Takada

   Original Articles Pages: 323 - 330

10. Phase I study of high-dose cisplatin, ifosfamide, and etoposide

    • Edith A. Perez
    • Paul C. Sowray
    • David R. Gandara

    Original Articles Pages: 331 - 334

11. Comparative effects of taxol and Taxotere on two different human carcinoma cell lines

    • Patrick Garcia
    • Diane Braguer
    • Claudette Briand

    Original Articles Pages: 335 - 343

12. Increased intracellular Ca²⁺ signaling caused by the antitumor agent helenalin and its analogues

    • Garth Powis
    • Alfred Gallegos
    • Rosanne Bonjouklian

    Original Articles Pages: 344 - 350

13. Growth kinetics of L1210 leukemic cells exposed to different concentration courses of methotrexate in vitro

    • Stefan Gimmel
    • H. Rainer Maurer

    Original Articles Pages: 351 - 355

14. Bi-weekly vincristine, epirubicin and methylprednisolone in alkylator-refractory multiple myeloma

    • Mark Vincent
    • Glen Goss
    • Robert Corringham

    Clinical Trial Report Pages: 356 - 360

15. Response rates — An evolution

    • Elizabeth Poplin
    • Laurence Baker

    Short Communication Pages: 361 - 363

16. Meeting announcements

    Announcement Pages: 364 - 364