1. Combined cytotoxic action of paclitaxel and ceramide against the human Tu138 head and neck squamous carcinoma cell line

   • Shashi Mehta
   • Dilshad Blackinton
   • Harold Wanebo

   ORIGINAL ARTICLE Pages: 85 - 92

2. Interaction of dexrazoxane with red blood cells and hemoglobin alters pharmacokinetics of doxorubicin

   • Sujata Vaidyanathan
   • Mehdi Boroujerdi

   ORIGINAL ARTICLE Pages: 93 - 100

3. F 11782, a dual inhibitor of topoisomerases I and II with an original mechanism of action in vitro, and markedly superior in vivo antitumour activity, relative to three other dual topoisomerase inhibitors, intoplicin, aclarubicin and TAS-103

   • Chantal Etiévant
   • Anna Kruczynski
   • Bridget T. Hill

   ORIGINAL ARTICLE Pages: 101 - 113

4. Retrospective comparison of toxicity and efficacy in phase II trials of 3-h infusions of paclitaxel for patients 70 years of age or older and patients under 70 years of age

   • Yoichi Nakamura
   • Ikuo Sekine
   • Nagahiro Saijo

   ORIGINAL ARTICLE Pages: 114 - 118

5. Reduction of cyclophosphamide bioactivation by thioTEPA: critical sequence-dependency in high-dose chemotherapy regimens

   • Alwin D. R. Huitema
   • Thomas Kerbusch
   • Jos H. Beijnen

   ORIGINAL ARTICLE Pages: 119 - 127

6. Differences in uptake and metabolism of retinoic acid between estrogen receptor-positive and -negative human breast cancer cells

   • Kosuke Okamoto
   • Fausto Andreola
   • Luigi M. De Luca

   ORIGINAL ARTICLE Pages: 128 - 134

7. Modulation of the pharmacokinetics of the antitumour agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in mice by thalidomide

   • Philip Kestell
   • Liangli Zhao
   • Lai-Ming Ching

   ORIGINAL ARTICLE Pages: 135 - 141

8. Antitumor activity of cryptophycins: effect of infusion time and combination studies

   • Krishna Menon
   • Enrique Alvarez
   • Beverly A. Teicher

   ORIGINAL ARTICLE Pages: 142 - 149

9. Pharmacokinetics of oral O⁶-benzylguanine and evidence of interaction with oral ketoconazole in the rat

   • Reginald B. Ewesuedo
   • M. Eileen Dolan

   ORIGINAL ARTICLE Pages: 150 - 155

10. Pharmacokinetics and antitumor properties in tumor-bearing mice of an enediol analogue inhibitor of glyoxalase I

    • Ellyn M. Sharkey
    • Hugh B. O'Neill
    • Julie L. Eiseman

    ORIGINAL ARTICLE Pages: 156 - 166

11. Carzelesin phase II study in advanced breast, ovarian, colorectal, gastric, head and neck cancer, non-Hodgkin's lymphoma and malignant melanoma: a study of the EORTC early clinical studies group (ECSG)

    • Nicholas Pavlidis
    • Steinar Aamdal
    • Axel-R. Hanauske

    CLINICAL TRIAL REPORT Pages: 167 - 171

12. Erratum: Cancer Chemother Pharmacol 45: 133–141

    Pages: 172 - 172