Innovative monotherapy trial designs for the assessment of antiepileptic drugs: a critical appraisal E. Perucca SPECIAL ARTICLE Pages: 1 - 5
Clinical and toxicological consequences of the inductive potential of ethanol U. KlotzE. Ammon SPECIAL ARTICLE Pages: 7 - 12
Adverse events in phase-I studies: a report in 1015 healthy volunteers M. SibilleN. DeigatD. Vital Durand CLINICAL TRIALS Pages: 13 - 20
Effect of prostaglandin E1 on pulmonary hypertension after protamine injection during cardiac surgery K. AbeT. SakakibaraK. Ohnishi PHARMACODYNAMICS Pages: 21 - 25
The efficacy of a low-dose, monodisperse parasympathicolytic aerosol compared with a standard aerosol from a metered-dose inhaler P. ZanenL. T. GoJ.-W. J. Lammers PHARMACODYNAMICS Pages: 27 - 30
Comparison of venodilatory effect of nicardipine, diltiazem, and verapamil in human subjects K. HaradaM. OhmoriA. Fujimura PHARMACODYNAMICS Pages: 31 - 34
Dilatory effects of phosphodiesterase inhibitors on human hand veins in vivo M. GrossmannJ. BrauneW. Kirch PHARMACODYNAMICS Pages: 35 - 39
Nonformulary drug requests at an academic hospital in Germany – the role of general practitioners' long-term medication W. HimmelB. LönkerM. M. Kochen PHARMACOEPIDEMIOLOGY AND PRESCRIPTION Pages: 41 - 46
Influence of donor and recipient genotypes on CYP2D6 phenotype after liver transplantation: a study of mutations CYP2D6*3 and CYP2D6*4 O. MonekG. PaintaudP. R. Bechtel PHARMACOKINETICS AND DISPOSITION Pages: 47 - 52
The area under the plasma concentration–time curve for oral midazolam is 400-fold larger during treatment with itraconazole than with rifampicin J. T. BackmanK. T. KivistöP. J. Neuvonen PHARMACOKINETICS AND DISPOSITION Pages: 53 - 58
Pharmacokinetics of imidapril and its active metabolite imidaprilat following single dose and during steady state in patients with chronic renal failure J. F. W. HoogkamerC. H. KleinbloesemW. Kirch PHARMACOKINETICS AND DISPOSITION Pages: 59 - 61
Pharmacokinetics and pharmacodynamics of acetazolamide in patients with transient intraocular pressure elevation I. YanoA. TakayamaK. Inui PHARMACOKINETICS AND DISPOSITION Pages: 63 - 68
Detection of a drug–drug interaction on population-based phenobarbitone clearance using nonlinear mixed-effects modeling E. YukawaH. ToT. Aoyama PHARMACOKINETICS AND DISPOSITION Pages: 69 - 74
The interaction effect of grapefruit juice is maximal after the first glass J. U. E. LundahlC. G. RegårdhG. Johnsson PHARMACOKINETICS AND DISPOSITION Pages: 75 - 81
Pharmacokinetic studies of mitoxantrone and one of its metabolites in serum and urine in patients with advanced breast cancer K. M. RentschR. A. SchwendenerE. Hänseler PHARMACOKINETICS AND DISPOSITION Pages: 83 - 89
Rifaximin systemic absorption in patients with ulcerative colitis F. RizzelloP. GionchettiM. Campieri LETTER TO THE EDITORS Pages: 91 - 93
Digitoxin intoxication during concomitant use of amiodarone S. LäerH. ScholzT. Meinertz LETTER TO THE EDITORS Pages: 95 - 96