1. Preface

   • W. Bleifeld
   • H. Grobecker
   • B. Lüderitz

   EditorialNotes Pages: S1 - S1

2. Pharmacology and clinical pharmacology of organic nitrates

   • H. Grobecker

   OriginalPaper Pages: S3 - S7

3. Mechanisms of nitrate-induced vasodilatation and tolerance

   • W. R. Kukovetz
   • S. Holzmann

   OriginalPaper Pages: S9 - S14

4. Development of long-acting nitrate delivery systems

   • U. E. Jonsson

   OriginalPaper Pages: S15 - S19

5. Nitrate tolerance

   • J. O. Parker

   OriginalPaper Pages: S21 - S25

6. Nitrate patches: Duration of action and loss of efficacy

   • W. -D. Bussmann

   OriginalPaper Pages: S27 - S29

7. Lack of tolerance after chronic administration of controlled-release isosorbide-5-mononitrate

   • M. Stauch
   • G. Grossmann
   • W. -E. Adam

   OriginalPaper Pages: S31 - S34

8. Nitrates: Why and how should they be used today?

   • S. Silber

   OriginalPaper Pages: S35 - S51

9. Relationship between pharmacokinetics and hemodynamic tolerance to isosorbide-5-mononitrate

   • F. Wagner
   • F. Siefert
   • E. Jähnchen

   OriginalPaper Pages: S53 - S59

10. Anti-ischemic and antianginal effects of 60 mg isosorbide-5-mononitrate in patients treated chronically after myocardial infarction

    • N. Wrobel

    OriginalPaper Pages: S61 - S64

11. Clinical experience with Imdur in angina pectoris

    • G. Nyberg

    OriginalPaper Pages: S65 - S68

12. Silent myocardial ischemia: A special aspect of coronary artery disease

    • B. Lüderitz

    OriginalPaper Pages: S69 - S71

13. Unstable angina: Pathophysiology and drug therapy

    • W. Bleifeld

    OriginalPaper Pages: S73 - S76