1. Modulation of GABA_A receptor-mediated currents by phenazepam and its metabolites

   • Maksim V. Kopanitsa
   • Olga V. Zhuk
   • Oleg A. Krishtal

   Original Article Pages: 1 - 8

2. Dibenzylamine – a novel blocker of the voltage-dependent K⁺ current in myocardial mouse cells

   • Bettina Doepner
   • Rolf Koopmann
   • Klaus Benndorf

   Original Article Pages: 9 - 13

3. Novel histaprodifen analogues as potent histamine H₁-receptor agonists in the pithed and in the anaesthetized rat

   • E. Schlicker
   • H. Kozłowska
   • W. Schunack

   Original Article Pages: 14 - 20

4. Characterization of antidepressant-like effects of p-synephrine stereoisomers

   • Kee-Won Kim
   • Hee-Doo Kim
   • Dong-Keun Song

   Original Article Pages: 21 - 26

5. Pharmacological profile of the mechanisms involved in the external carotid vascular effects of the antimigraine agent isometheptene in anaesthetised dogs

   • Edwin W. Willems
   • Luis Valdivia
   • Carlos M. Villalón

   Original Article Pages: 27 - 32

6. Effects of the cardioselective K_ATP channel blocker HMR 1098 on cardiac function in isolated perfused working rat hearts and in anesthetized rats during ischemia and reperfusion

   • Heinz Gögelein
   • Hartmut Ruetten
   • Andreas E. Busch

   Original Article Pages: 33 - 41

7. Failure of endothelin-1 to activate store-operated Ca²⁺ channels by lack of mobilization from intracellular Ca²⁺ stores in cultured bovine adrenal chromaffin cells

   • Ken Lee
   • Hironobu Morita
   • Soichi Miwa

   Original Article Pages: 42 - 46

8. Glucose-induced insulin secretion is potentiated by a new imidazoline compound

   • Hans-Jürgen Mest
   • Achim Raap
   • Veikko Koivisto

   Original Article Pages: 47 - 52

9. Bradykinin causes inhibition of methacholine-induced bronchoconstriction in vivo in mice

   • Gert Folkerts
   • Dicky van Heuven-Nolsen
   • Frans P. Nijkamp

   Original Article Pages: 53 - 58

10. Nitric oxide induces hydroxyl radical generation in rat hearts via depolarization-induced nitric oxide synthase activation

    • Toshio Obata
    • Yasumitsu Yamanaka

    Original article Pages: 59 - 65

11. Effects of the cannabimimetic fatty acid derivatives 2-arachidonoylglycerol, anandamide, palmitoylethanolamide and methanandamide upon IgE-dependent antigen-induced β-hexosaminidase, serotonin and TNFα release from rat RBL-2H3 basophilic leukaemia cells

    • Malin Granberg
    • Christopher J. Fowler
    • Stig O. Jacobsson

    Original Article Pages: 66 - 73

12. Differential effects of trihexyphenidyl on place preference conditioning and locomotor stimulant activity of cocaine and methamphetamine

    • Kazuaki Shimosato
    • Satoru Watanabe
    • Shigeo Kitayama

    Original Article Pages: 74 - 80

13. Effects of a novel, selective, σ₁-ligand, MS-377, on phencyclidine-induced behaviour

    • S. Takahashi
    • K. Takagi
    • K. Horikomi

    Original Article Pages: 81 - 86