1. Metabolic activations of polycyclic hydrocarbons

   • Roland E. Lehr
   • Donald M. Jerina

   OriginalPaper Pages: 1 - 6

2. Metabolic activation of chlorinated ethylenes: dependence of mutagenic effect on electrophilic reactivity of the metabolically formed epoxides

   • D. Henschler
   • G. Bonse

   OriginalPaper Pages: 7 - 12

3. Structural modifications in contraceptive steroids altering their metabolism and toxicity

   • H. M. Bolt

   OriginalPaper Pages: 13 - 19

4. Metabolic activation of diethylstilbestrol and aminostilbene-derivatives

   • H. -G. Neumann
   • M. Metzler
   • W. Töpner

   OriginalPaper Pages: 21 - 30

5. The significance of covalent binding of catechols to proteins in vivo

   • H. Remmer
   • M. Scheulen
   • H. M. Bolt

   OriginalPaper Pages: 31 - 39

6. Multiple forms of cytochrome P450

   • Volker Ullrich
   • Pierre Kremers

   OriginalPaper Pages: 41 - 50

7. Some aspects of metabolic activation of chemical carcinogens in relation to their organ specificity

   • H. Bartsch
   • G. P. Margison
   • M. Wiessler

   OriginalPaper Pages: 51 - 63

8. Dual role of epoxide hydratase in both activation and inactivation of benzo(a)pyrene

   • Philip Bentley
   • Franz Oesch
   • Hansruedi Glatt

   OriginalPaper Pages: 65 - 75

9. Dual role of glucuronyl- and sulfotransferases converting xenobiotics into reactive or biologically inactive and easily excretable compounds

   • K. W. Bock

   OriginalPaper Pages: 77 - 85

10. Inactivation of electrophilic metabolites by glutathione S-transferases and limitation of the system due to subcellular localization

    • Hansruedi Glatt
    • Franz Oesch

    OriginalPaper Pages: 87 - 96

11. Species differences in activating and inactivating enzymes related to the control of mutagenic metabolites

    • F. Oesch
    • D. Raphael
    • H. R. Glatt

    OriginalPaper Pages: 97 - 108

12. Birth defects and aplastic anemia: differences in polycyclic hydrocarbon toxicity associated with the Ah locus

    • Daniel W. Nebert
    • Roy C. Levitt
    • James S. Felton

    OriginalPaper Pages: 109 - 132

13. Activation of xenobiotics by monooxygenases: cultures of mammalian cells as analytical tool

    • Friedrich J. Wiebel
    • Stuart Brown
    • James K. Selkirk

    OriginalPaper Pages: 133 - 148

14. Enzymic control of irreversible binding of metabolically activated benzo(a)pyrene in perfused rat liver by monooxygenase activity

    • Georg F. Kahl
    • Erik Klaus
    • Regine Kahl

    OriginalPaper Pages: 149 - 158

15. Mutagenicity and chromosomal aberrations as an analytical tool for in vitro detection of mammalian enzyme-mediated formation of reactive metabolites

    • H. Greim
    • D. Bimboes
    • Maria Krämer

    OriginalPaper Pages: 159 - 169

16. Abstract

    • I. F. H. Purchase
    • E. Longstaff
    • F. R. Westwood

    Abstract Pages: 171 - 171