1. A genome on shaky ground: exploring the impact of mitochondrial DNA integrity on Parkinson’s disease by highlighting the use of cybrid models

   • Martin Lang
   • Anne Grünewald
   • Irene Pichler

   Review Open access 05 May 2022 Article: 283

   

2. Lipid-induced monokine cyclophilin-A promotes adipose tissue dysfunction implementing insulin resistance and type 2 diabetes in zebrafish and mice models of obesity

   • Dipanjan Banerjee
   • Debarun Patra
   • Suman Dasgupta

   Original Article 05 May 2022 Article: 282

   

3. The mechanism of activation of MEK1 by B-Raf and KSR1

   • Ryan C. Maloney
   • Mingzhen Zhang
   • Ruth Nussinov

   Original Article Open access 04 May 2022 Article: 281

   

4. Disruption of ZNF334 promotes triple-negative breast carcinoma malignancy through the SFRP1/ Wnt/β-catenin signaling axis

   • Zhaobo Cheng
   • Renjie Yu
   • Tingxiu Xiang

   Original Article 04 May 2022 Article: 280

   

5. PUMILIO-mediated translational control of somatic cell cycle program promotes folliculogenesis and contributes to ovarian cancer progression

   • Xin Li
   • Mengyi Zhu
   • Eugene Yujun Xu

   Original Article 04 May 2022 Article: 279

   

6. SRF depletion in early life contributes to social interaction deficits in the adulthood

   • Matylda Roszkowska
   • Anna Krysiak
   • Katarzyna Kalita

   Original Article Open access 04 May 2022 Article: 278

   

7. GHSR controls food deprivation-induced activation of CRF neurons of the hypothalamic paraventricular nucleus in a LEAP2-dependent manner

   • Gimena Fernandez
   • Agustina Cabral
   • Mario Perello

   Original Article 04 May 2022 Article: 277

   

8. New insights into the molecular mechanisms of ROR1, ROR2, and PTK7 signaling from the proteomics and pharmacological modulation of ROR1 interactome

   • Juuli Raivola
   • Alice Dini
   • Daniela Ungureanu

   Original Article Open access 04 May 2022 Article: 276

   

9. Trafficking and retention of protein antigens across systems and immune cell types

   • Thu A. Doan
   • Tadg Forward
   • Beth A. Jirón Tamburini

   Review 03 May 2022 Article: 275

   

10. Modifier pathways in polyglutamine (PolyQ) diseases: from genetic screens to drug targets

    • Marta Daniela Costa
    • Patrícia Maciel

    Review 03 May 2022 Article: 274

    

11. Anti-inflammatory effect of SGLT-2 inhibitors via uric acid and insulin

    • Rosalba La Grotta
    • Paola de Candia
    • Francesco Prattichizzo

    Original Article Open access 03 May 2022 Article: 273

    

12. Adipokines, adiposity, and atherosclerosis

    • Longhua Liu
    • Zunhan Shi
    • Li Qiang

    Review 03 May 2022 Article: 272

    

13. Nucleolin: a cell portal for viruses, bacteria, and toxins

    • Fiorella Tonello
    • Maria Lina Massimino
    • Caterina Peggion

    Review Open access 03 May 2022 Article: 271

    

14. RIP140 inhibits glycolysis-dependent proliferation of breast cancer cells by regulating GLUT3 expression through transcriptional crosstalk between hypoxia induced factor and p53

    • Valentin Jacquier
    • Delphine Gitenay
    • Catherine Teyssier

    Original Article Open access 03 May 2022 Article: 270

    

15. Soluble RAGE attenuates myocardial I/R injuries via FoxO3–Bnip3 pathway

    • Jie Zhang
    • Xuejie Han
    • Caixia Guo

    Original Article 02 May 2022 Article: 269

    

16. FBXW2 inhibits prostate cancer proliferation and metastasis via promoting EGFR ubiquitylation and degradation

    • Tao Zhou
    • Tingting Chen
    • Jie Xu

    Original Article Open access 02 May 2022 Article: 268

    

17. Cutaneous nerve fibers participate in the progression of psoriasis by linking epidermal keratinocytes and immunocytes

    • Si-Qi Chen
    • Xue-Yan Chen
    • Xiao-Yong Man

    Original Article 30 April 2022 Article: 267

    

18. Hedgehog signaling and its molecular perspective with cholesterol: a comprehensive review

    • Jyoti B. Kaushal
    • Surinder K. Batra
    • Satyanarayana Rachagani

    Review 29 April 2022 Article: 266

    

19. Impaired regulation of PMCA activity by defective CFTR expression promotes epithelial cell damage in alcoholic pancreatitis and hepatitis

    • Tamara Madácsy
    • Árpád Varga
    • József Maléth

    Original Article 28 April 2022 Article: 265

    

20. SMA^{low/undetectable} pericytes differentiate into microglia- and macrophage-like cells in ischemic brain

    • Abhijit Nirwane
    • Yao Yao

    Original Article 28 April 2022 Article: 264

    

21. Listeria monocytogenes exposed to antimicrobial peptides displays differential regulation of lipids and proteins associated to stress response

    • Paolo Stincone
    • Flávio Fonseca Veras
    • Adriano Brandelli

    Original Article 28 April 2022 Article: 263

    

22. Calpains as novel players in the molecular pathogenesis of spinocerebellar ataxia type 17

    • Jonasz Jeremiasz Weber
    • Stefanie Cari Anger
    • Huu Phuc Nguyen

    Original Article Open access 28 April 2022 Article: 262

    

23. CYP311A1 in the anterior midgut is involved in lipid distribution and microvillus integrity in Drosophila melanogaster

    • Wei Dong
    • Xubo Zhang
    • Jianzhen Zhang

    Original Article 28 April 2022 Article: 261

    

24. CEMIP (KIAA1199) regulates inflammation, hyperplasia and fibrosis in osteoarthritis synovial membrane

    • Céline Deroyer
    • Christophe Poulet
    • Dominique de Seny

    Original Article Open access 27 April 2022 Article: 260

    

25. Effective high-throughput isolation of enriched platelets and circulating pro-angiogenic cells to accelerate skin-wound healing

    • Silvia Erratico
    • Marzia Belicchi
    • Yvan Torrente

    Original Article Open access 26 April 2022 Article: 259

    

26. Impaired primordial follicle assembly in offspring ovaries from zearalenone-exposed mothers involves reduced mitochondrial activity and altered epigenetics in oocytes

    • Yan-Qin Feng
    • Jun-Jie Wang
    • Wei Shen

    Original Article 26 April 2022 Article: 258

    

27. Downregulation of epithelial sodium channel (ENaC) activity in cystic fibrosis cells by epigenetic targeting

    • Giovanna Blaconà
    • Roberto Raso
    • Marco Lucarelli

    Original Article Open access 25 April 2022 Article: 257

    

28. Skeletal muscle cell-specific differences in type 2 diabetes

    • Noni T. Frankenberg
    • Shaun A. Mason
    • Robyn M. Murphy

    Original Article Open access 23 April 2022 Article: 256

    

29. uPARAP/Endo180: a multifaceted protein of mesenchymal cells

    • Fabrice Gucciardo
    • Sébastien Pirson
    • Agnès Noël

    Review Open access 22 April 2022 Article: 255

    

30. Hotair promotes the migration and proliferation in ovarian cancer by miR-222-3p/CDK19 axis

    • Lili Fan
    • Han Lei
    • Gang Yin

    Original Article Open access 22 April 2022 Article: 254

    

31. CircACTR2 in macrophages promotes renal fibrosis by activating macrophage inflammation and epithelial–mesenchymal transition of renal tubular epithelial cells

    • Hua Fu
    • Yong-Hong Gu
    • Guo-Hui Wang

    Original Article 21 April 2022 Article: 253

    

32. The human dental apical papilla promotes spinal cord repair through a paracrine mechanism

    • P. De Berdt
    • K. Vanvarenberg
    • A. des Rieux

    Original Article 21 April 2022 Article: 252

    

33. Liquid–liquid phase separation as an organizing principle of intracellular space: overview of the evolution of the cell compartmentalization concept

    • Iuliia A. Antifeeva
    • Alexander V. Fonin
    • Konstantin K. Turoverov

    Review 20 April 2022 Article: 251

    

34. Galectin-3 interferes with tissue repair and promotes cardiac dysfunction and comorbidities in a genetic heart failure model

    • Fani Vlachou
    • Aimilia Varela
    • Stelios Psarras

    Original Article 19 April 2022 Article: 250

    

35. Traumatic-noise-induced hair cell death and hearing loss is mediated by activation of CaMKKβ

    • Fan Wu
    • Kayla Hill
    • Su-Hua Sha

    Original Article 19 April 2022 Article: 249

    

36. PI(4,5)P2 controls slit diaphragm formation and endocytosis in Drosophila nephrocytes

    • Maximilian M. Gass
    • Sarah Borkowsky
    • Michael P. Krahn

    Original Article Open access 18 April 2022 Article: 248

    

37. Platelets fine-tune effector responses of naïve CD4⁺ T cells via platelet factor 4-regulated transforming growth factor β signaling

    • Yanan Min
    • Long Hao
    • Nailin Li

    Original Article Open access 18 April 2022 Article: 247

    

38. Molecular mechanisms of aberrant neutrophil differentiation in glycogen storage disease type Ib

    • Sang Wan Sim
    • Yuyeon Jang
    • Hyun Sik Jun

    Original Article 18 April 2022 Article: 246

    

39. Experimental colonization with Blastocystis ST4 is associated with protective immune responses and modulation of gut microbiome in a DSS-induced colitis mouse model

    • Lei Deng
    • Lukasz Wojciech
    • Kevin Shyong Wei Tan

    Original Article Open access 18 April 2022 Article: 245

    

40. The extracellular matrix molecule tenascin-C modulates cell cycle progression and motility of adult neural stem/progenitor cells from the subependymal zone

    • Elena Schaberg
    • Magdalena Götz
    • Andreas Faissner

    Original Article Open access 16 April 2022 Article: 244

    

41. The role of bile acids in carcinogenesis

    • Tadeja Režen
    • Damjana Rozman
    • Edit Mikó

    Review Open access 16 April 2022 Article: 243

    

42. Molecular dissection on inhibition of Ras-induced cellular senescence by small t antigen of SV40

    • Dongsheng Shang
    • Tianchu Zhou
    • Zhigang Tu

    Original Article 16 April 2022 Article: 242

    

43. Interaction of ToLCNDV TrAP with SlATG8f marks it susceptible to degradation by autophagy

    • Ashish Prasad
    • Manoj Prasad

    Original Article 15 April 2022 Article: 241

    

44. Novel contact–kinin inhibitor sylvestin targets thromboinflammation and ameliorates ischemic stroke

    • Zhiye Zhang
    • Chuanbin Shen
    • Ren Lai

    Original Article 13 April 2022 Article: 240

    

45. Mitochondrial function in spinal cord injury and regeneration

    • Paula G. Slater
    • Miguel E. Domínguez-Romero
    • Juan Larraín

    Review 13 April 2022 Article: 239

    

46. Two distinct males absent on the first (MOF)-containing histone acetyltransferases are involved in the epithelial–mesenchymal transition in different ways in human cells

    • Tao Wei
    • Hongsen Liu
    • Jingji Jin

    Original Article 13 April 2022 Article: 238

    

47. The E3 ubiquitin ligase SMURF2 stabilizes RNA editase ADAR1p110 and promotes its adenosine-to-inosine (A-to-I) editing function

    • Praveen Koganti
    • Venkata Narasimha Kadali
    • Michael Blank

    Original Article 11 April 2022 Article: 237

    

48. MALL, a membrane-tetra-spanning proteolipid overexpressed in cancer, is present in membraneless nuclear biomolecular condensates

    • Armando Rubio-Ramos
    • Miguel Bernabé-Rubio
    • Miguel A. Alonso

    Original Article Open access 10 April 2022 Article: 236

    

49. Rapid shear stress-dependent ENaC membrane insertion is mediated by the endothelial glycocalyx and the mineralocorticoid receptor

    • Zülfü C. Cosgun
    • Magdalena Sternak
    • Kristina Kusche-Vihrog

    Original Article Open access 10 April 2022 Article: 235

    

50. A53T mutant α-synuclein fibrils formed in macrophage are spread to neurons

    • Shogo Moriya
    • Michiko Hanazono
    • Masaki Takiguchi

    Original Article 10 April 2022 Article: 234