Hidden secrets of the cancer genome: unlocking the impact of non-coding mutations in gene regulatory elements Sandra Iñiguez-MuñozPere Llinàs-AriasDiego M. Marzese Review Open access 20 June 2024 Article: 274
Novel role of NCoR1 in impairing spatial memory through the mediation of a novel interacting protein DEC2 Kuang-Min ChengWei-Lun HsuEminy H. Y. Lee Original Article Open access 20 June 2024 Article: 273
Direct GPCR-EGFR interaction enables synergistic membrane-to-nucleus information transfer Michael GekleRobert EckenstalerRalf Benndorf Original Article Open access 20 June 2024 Article: 272
Targeting ubiquitination machinery in cystic fibrosis: Where do we stand? Tsukasa OkiyonedaChristian BorgoMauro Salvi Review Open access 18 June 2024 Article: 271
Uncovering the role of TET2-mediated ENPEP activation in trophoblast cell fate determination Wen HuangAndy Chun Hang ChenYin Lau Lee Original Article Open access 17 June 2024 Article: 270
Unveiling the crucial role of betaine: modulation of GABA homeostasis via SLC6A1 transporter (GAT1) Manan BhattErika LazzarinElena Bossi Original Article Open access 17 June 2024 Article: 269
Glycine-induced activation of GPR158 increases the intrinsic excitability of medium spiny neurons in the nucleus accumbens Giuseppe AcetoLuca NardellaClaudio Grassi Original Article Open access 17 June 2024 Article: 268
Virus neutralization assays for human respiratory syncytial virus using airway organoids Laura L.A. van DijkLaurine C. RijsbergenRory D. de Vries Original Article Open access 17 June 2024 Article: 267
Revealing molecular determinants governing mambalgin-3 pharmacology at acid-sensing ion channel 1 variants Ben Cristofori-ArmstrongElena BudusanLachlan D. Rash Original Article Open access 17 June 2024 Article: 266
Disturbed glycolipid metabolism activates CXCL13-CXCR5 axis in senescent TSCs to promote heterotopic ossification Yuyu ChenJinna WuHang Zhou Original Article Open access 17 June 2024 Article: 265
Prostaglandin I2 signaling prevents angiotensin II-induced atrial remodeling and vulnerability to atrial fibrillation in mice Yue ZhangMeng YuanGuangping Li Original Article Open access 15 June 2024 Article: 264
Structure, regulation, and mechanisms of nonmuscle myosin-2 Krishna ChinthalapudiSarah M. Heissler Review Open access 15 June 2024 Article: 263
Disrupting Smad3 potentiates immunostimulatory function of NK cells against lung carcinoma by promoting GM-CSF production Guang-Yu LianQing-Ming WangHui-Yao Lan Original Article Open access 15 June 2024 Article: 262
Phospholipid scramblase 1: an essential component of the nephrocyte slit diaphragm Vicente Castillo-ManchoAlexandra Atienza-ManuelJoaquim Culi Original Article Open access 15 June 2024 Article: 261
EEF1B2 regulates bone marrow-derived mesenchymal stem cells bone-fat balance via Wnt/β-catenin signaling Shuhao FengZihang FengLiang Zhao Original Article Open access 15 June 2024 Article: 260
The novel function of an orphan pheromone receptor reveals the sensory specializations of two potential distinct types of sex pheromones in noctuid moth Chenrui WangSong CaoYang Liu Original Article Open access 15 June 2024 Article: 259
Otud6b induces pulmonary arterial hypertension by mediating the Calpain-1/HIF-1α signaling pathway Yu LiuBailin TangMeili Lu Original Article Open access 15 June 2024 Article: 258
Directed-evolution mutations enhance DNA-binding affinity and protein stability of the adenine base editor ABE8e Haixia ZhuLei WangQiang Huang Original Article Open access 14 June 2024 Article: 257
N6-methyladenosine-driven miR-143/145-KLF4 circuit orchestrates the phenotypic switch of pulmonary artery smooth muscle cells Kang KangChuannan SunDeming Gou Original Article Open access 12 June 2024 Article: 256
Interaction of NF-κB and FOSL1 drives glioma stemness Vanajothi RamarShanchun GuoMingli Liu Original Article Open access 10 June 2024 Article: 255
Pyruvate kinase M2 sustains cardiac mitochondrial quality surveillance in septic cardiomyopathy by regulating prohibitin 2 abundance via S91 phosphorylation Yingzhen DuJialei LiYijin Wang Original Article Open access 10 June 2024 Article: 254
Poly (ADP-ribose) polymerase 1 promotes HuR/ELAVL1 cytoplasmic localization and inflammatory gene expression by regulating p38 MAPK activity Xingyue FuJiaqi ZhangYueshuang Ke Original Article Open access 09 June 2024 Article: 253
C. elegans foraging as a model for understanding the neuronal basis of decision-making Jessica A. HaleySreekanth H. Chalasani Review Open access 08 June 2024 Article: 252
Crucial role of the NSE1 RING domain in Smc5/6 stability and FANCM-independent fork progression Neus P LoriteSonia ApostolovaJordi Torres-Rosell Original Article Open access 07 June 2024 Article: 251
Redox regulation of UPR signalling and mitochondrial ER contact sites Jose C. Casas-MartinezAfshin SamaliBrian McDonagh Review Open access 07 June 2024 Article: 250
Legionella effectors SidC/SdcA ubiquitinate multiple small GTPases and SNARE proteins to promote phagosomal maturation Kelong MaRundong ShuJiazhang Qiu Original Article Open access 05 June 2024 Article: 249
LUZP1 regulates the maturation of contractile actomyosin bundles Liang WangHoi Ying TsangHongxia Zhao Original Article Open access 04 June 2024 Article: 248
UCHL3 induces radiation resistance and acquisition of mesenchymal phenotypes by deubiquitinating POLD4 in glioma stem cells Ligang FanHongtao YouNaiyuan Shao Original Article Open access 03 June 2024 Article: 247
The GPI-anchor biosynthesis pathway is critical for syncytiotrophoblast differentiation and placental development Andrea Álvarez-SánchezJohanna GrinatVicente Pérez-García Original Article Open access 31 May 2024 Article: 246
The bacterial DNA sliding clamp, β-clamp: structure, interactions, dynamics and drug discovery Signe SimonsenCaroline K. SøgaardBirthe B. Kragelund Review Open access 30 May 2024 Article: 245
Proximal tubular FHL2, a novel downstream target of hypoxia inducible factor 1, is a protector against ischemic acute kidney injury Yan WangZiwei KuangWeichun He Original Article Open access 30 May 2024 Article: 244
Correction: Flotillins affect LPS-induced TLR4 signaling by modulating the trafficking and abundance of CD14 Orest V. MatveichukAnna CiesielskaKatarzyna Kwiatkowska Correction Open access 30 May 2024 Article: 243
Mechanically guided cell fate determination in early development Delan N. AlasaadiRoberto Mayor Review Open access 30 May 2024 Article: 242
Glucose and HODEs regulate Aspergillus ochraceus quorum sensing through the GprC-AcyA pathway Jing GaoHuiqing LiuZhihong Liang Original Article Open access 29 May 2024 Article: 241
Disruption of pulmonary microvascular endothelial barrier by dysregulated claudin-8 and claudin-4: uncovered mechanisms in porcine reproductive and respiratory syndrome virus infection Weifeng SunWeixin WuHanchun Yang Original Article Open access 28 May 2024 Article: 240
Is CAA a perivascular brain clearance disease? A discussion of the evidence to date and outlook for future studies Susanne J. van VeluwHelene BenvenisteMatthias J. P. van Osch Review Open access 27 May 2024 Article: 239
Targeting NG2 relieves the resistance of BRAF-mutant thyroid cancer cells to BRAF inhibitors Fang SuiGuanjie WangPeng Hou Original Article Open access 25 May 2024 Article: 238
NEK2 promotes the development of ovarian endometriosis and impairs decidualization by phosphorylating FOXO1 Mengxue WangFangyuan SunTingting Yang Original Article Open access 25 May 2024 Article: 237
EFHD1 promotes osteosarcoma proliferation and drug resistance by inhibiting the opening of the mitochondrial membrane permeability transition pore (mPTP) by binding to ANT3 Xin ShenMengjun MaHuiyong Shen Original Article Open access 25 May 2024 Article: 236
Rescuing tri-heteromeric NMDA receptor function: the potential of pregnenolone-sulfate in loss-of-function GRIN2B variants Shai KellnerShai Berlin Original Article Open access 25 May 2024 Article: 235
Proteomic dissection of vanishing white matter pathogenesis Jodie H. K. ManParand ZarekianiMarianna Bugiani Original Article Open access 24 May 2024 Article: 234
Circulating tumour cells predict recurrences and survival in head and neck squamous cell carcinoma patients Xi ZhangChameera Ekanayake WeeramangeChamindie Punyadeera Original Article Open access 23 May 2024 Article: 233
Usp14 deficiency removes α-synuclein by regulating S100A8/A9 in Parkinson’s disease Liuyan DingLin LuPingyi Xu Original Article Open access 23 May 2024 Article: 232
CD200R activation on naïve T cells by B cells induces suppressive activity of T cells via IL-24 Kuan-Hua ChuBor-Luen Chiang Original Article Open access 23 May 2024 Article: 231
The evolutionary novelty of insect defensins: from bacterial killing to toxin neutralization Bin GaoShunyi Zhu Original Article Open access 23 May 2024 Article: 230
Dynamic changes in RNA m6A and 5 hmC influence gene expression programs during macrophage differentiation and polarisation Natalia PinelloRenhua SongJustin J.-L. Wong Original Article Open access 23 May 2024 Article: 229
Cardiac-specific PFKFB3 overexpression prevents diabetic cardiomyopathy via enhancing OPA1 stabilization mediated by K6-linked ubiquitination Jinlan LuoShuiqing HuXizhen Xu Original Article Open access 22 May 2024 Article: 228
Cellular depletion of major cathepsin proteases reveals their concerted activities for lysosomal proteolysis Lisa GallwitzFlorian BleibaumPaul Saftig Original Article Open access 22 May 2024 Article: 227
Cholesterol neutralized vemurafenib treatment by promoting melanoma stem-like cells via its metabolite 27-hydroxycholesterol Xiaohong WangFeiliang ZhongBo Li Original Article Open access 22 May 2024 Article: 226
Endothelial PDGF-D contributes to neurovascular protection after ischemic stroke by rescuing pericyte functions Maxime BernardRomain MenetAyman ElAli Original Article Open access 21 May 2024 Article: 225