1. REFINE special issue

   • Kathleen Spring
   • Klaus-M. Weltring
   • Ruth Schmid

   Preface Open access 26 July 2022 Pages: 2039 - 2041

2. Regulatory safety evaluation of nanomedical products: key issues to refine

   • Wim H. De Jong
   • Robert E. Geertsma
   • Gerrit Borchard

   Inspirational Note Open access 30 July 2022 Pages: 2042 - 2047

3. Three-dimensional (3D) liver cell models - a tool for bridging the gap between animal studies and clinical trials when screening liver accumulation and toxicity of nanobiomaterials

   • Melissa Anne Tutty
   • Dania Movia
   • Adriele Prina-Mello

   Review Open access 04 May 2022 Pages: 2048 - 2074

   

4. Subcellular detection of PEBCA particles in macrophages: combining darkfield microscopy, confocal Raman microscopy, and ToF–SIMS analysis

   • Antje Vennemann
   • Daniel Breitenstein
   • Martin Wiemann

   Original Article Open access 19 February 2022 Pages: 2075 - 2088

   

5. A multistep in vitro hemocompatibility testing protocol recapitulating the foreign body reaction to nanocarriers

   • Valeria Perugini
   • Ruth Schmid
   • Matteo Santin

   Original Article Open access 22 March 2022 Pages: 2089 - 2100

   

6. A Decision Support System for preclinical assessment of nanomaterials in medical products: the REFINE DSS

   • Alex Zabeo
   • Fabio Rosada
   • Danail Hristozov

   Original Article Open access 10 May 2022 Pages: 2101 - 2113

   

7. A comparative biodistribution study of polymeric and lipid-based nanoparticles

   • Andreas K. O. Åslund
   • Rob J. Vandebriel
   • Sven Even F. Borgos

   Original Article Open access 15 April 2022 Pages: 2114 - 2131

   

8. Physiologically based pharmacokinetic modeling of intravenously administered nanoformulated substances

   • Jordi Minnema
   • Sven Even F. Borgos
   • Christiaan Delmaar

   Original Article Open access 12 May 2022 Pages: 2132 - 2144

   

9. Future perspectives for advancing regulatory science of nanotechnology-enabled health products

   • Blanka Halamoda-Kenzaoui
   • Robert Geertsma
   • Susanne Bremer-Hoffmann

   Original Article Open access 12 June 2022 Pages: 2145 - 2156

   

10. Pre-clinical 2D and 3D toxicity response to a panel of nanomaterials; comparative assessment of NBM-induced liver toxicity

    • Melissa Anne Tutty
    • Gabriele Vella
    • Adriele Prina-Mello

    Original Article Open access 28 June 2022 Pages: 2157 - 2177

    

11. A physiologically based pharmacokinetic model to predict pegylated liposomal doxorubicin disposition in rats and human

    • Maiara Camotti Montanha
    • Alice Howarth
    • Marco Siccardi

    Original Article 13 May 2022 Pages: 2178 - 2186

    

12. Standardization of an in vitro assay matrix to assess cytotoxicity of organic nanocarriers: a pilot interlaboratory comparison

    • Kai Moritz Eder
    • Anne Marzi
    • Jürgen Schnekenburger

    Original Article Open access 06 July 2022 Pages: 2187 - 2206

    

13. Interlaboratory evaluation of a digital holographic microscopy–based assay for label-free in vitro cytotoxicity testing of polymeric nanocarriers

    • Anne Marzi
    • Kai Moritz Eder
    • Jürgen Schnekenburger

    Original Article Open access 08 July 2022 Pages: 2207 - 2224

    

14. An inter-laboratory comparison of an NLRP3 inflammasome activation assay and dendritic cell maturation assay using a nanostructured lipid carrier and a polymeric nanomedicine, as exemplars

    • Rob J. Vandebriel
    • Christopher A. W. David
    • Neill J. Liptrott

    Original Article Open access 15 July 2022 Pages: 2225 - 2242

    

15. Evaluating nanobiomaterial-induced DNA strand breaks using the alkaline comet assay

    • Melissa Anne Tutty
    • Gabriele Vella
    • Adriele Prina-Mello

    Original Article Open access 25 May 2022 Pages: 2243 - 2258

    

16. Correction: Evaluating nanobiomaterial-induced DNA strand breaks using the alkaline comet assay

    • Melissa Anne Tutty
    • Gabriele Vella
    • Adriele Prina-Mello

    Correction Open access 19 June 2022 Pages: 2259 - 2259