1. Pharmacokinetics of midazolam: comparison of sublingual and intravenous routes in rabbit

   • P. Odou
   • C. Barthélémy
   • H. Robert

   OriginalPaper Pages: 1 - 7

2. Heterogeneity of paracetamol metabolism in Gilbert’s syndrome

   • A. Esteban
   • M. Pérez-Mateo

   OriginalPaper Pages: 9 - 13

3. Microsomal metabolism of quinifuryl — a nitrofurylethenyl-quinolone antiseptic possessing antitumor activityin vitro

   • I. A. Degterev
   • P. C. L. Nogueira
   • A. E. Verces

   OriginalPaper Pages: 15 - 22

4. Pharmacokinetics of 2-methoxyphenylmetyrapone and 2-bromophenylmetyrapone in rats

   • I. P. Nnane
   • M-C. Tsai
   • I. Zolle

   OriginalPaper Pages: 23 - 29

5. Influence of diet on the pattern of gastrointestinal biotransformation of netobimin and albendazole sulphoxide in sheep

   • G. Virkel
   • A. Lifschitz
   • C. Lanusse

   OriginalPaper Pages: 31 - 37

6. A population approach to the forecasting of amikacin plasma and urinary levels using a prescribed dosage regimen

   • P. Joubert
   • F. Bressolle
   • R. Gomeni

   OriginalPaper Pages: 39 - 46

7. Bioequivalence assessment of three different estradiol formulations in postmenopausal women in an open, randomized, single-dose, 3-way cross-over study

   • C. J. Timmer
   • T. B. P. Geurts

   OriginalPaper Pages: 47 - 53

8. Formulation of controlled release microspheres containing nicardipine: the role of pharmacokinetic modeling and computer simulation

   • A. Mrhar
   • M. Bogataj
   • R. Karba

   OriginalPaper Pages: 55 - 61

9. Interaction of chlormezanone enantiomers with rat liver microsomes

   • W. Klinger
   • H. Oelschläger
   • A. Seeling

   OriginalPaper Pages: 63 - 68

10. Comparative open, randomized, cross-over bioequivalence study of two intravenous dexrazoxane formulations (Cardioxane® and ICRF-187) in patients with advanced breast cancer, treated with 5-fluorouracil-doxorubicin-cyclophosphamide (FDC)

    • H. Rosing
    • W. W. Ten Bokkel Huinink
    • J. H. Beijnen

    OriginalPaper Pages: 69 - 77

11. Pharmacokinetic interaction of diabecon (D-400) with rifampicin and nifedipine

    • S. K. Mitra
    • R. Sundaram
    • S. Gopumadhavan

    OriginalPaper Pages: 79 - 82

12. Isolation, identification and immunosuppressive activity of SDZ-IMM-125 metabolites from human liver microsomes

    • R. Dieden
    • R. K. Verbeeck
    • G. J. J. Lhoest

    OriginalPaper Pages: 83 - 90

13. Effect of tacrine hydrochloride on hepatic drug metabolism

    • T. C. Danbury
    • M. Eccles
    • C. J. Roberts

    OriginalPaper Pages: 91 - 96

14. Valproate metabolites in the rat brain — regional distribution in various brain areas

    • J. Darius
    • F. P. Meyer
    • K. Andreas

    OriginalPaper Pages: 97 - 104

15. Stereoselective de-ethylation of chloroquine in rat liver microsomes

    • P. Augustijns
    • L. Peeters
    • R. K. Verbeeck

    OriginalPaper Pages: 105 - 108

16. Events

    Announcement Pages: 109 - 112