Diabetologia - Special Issue: Developmental Origins
Type 2 diabetes, once considered a disease of old age, sadly now occurs not uncommonly in children and young adults. Diabetes thus affects everyone, from cradle to grave, and thus we have chosen ‘A life course perspective on diabetes: developmental origins and beyond’ as the theme of our 2019 special issue. The issue covers evolution and the diabesity epidemic, racial and sex differences in the burden of type 2 diabetes, under- and overnutrition and obesity/diabetes risk, maternal and paternal in utero programming, environmental agents as diabetes risk factors, the impact of early-life factors on type 1 diabetes, and cellular senescence and ageing effects in diabetes. We conclude with a piece tackling the question: what should governments do?
A life course perspective on diabetes: developmental origins and beyond. Sally M. Marshall. DOI: 10.1007/s00125-019-4954-6.
The diabesity epidemic in the light of evolution: insights from the capacity–load model. Jonathan C. K. Wells. DOI: 10.1007/s00125-019-4944-8.
Racial/ethnic differences in the burden of type 2 diabetes over the life course: a focus on the USA and India. Sherita H. Golden, Chittaranjan Yajnik, Sanat Phatak, et al. DOI: 10.1007/s00125-019-4968-0.
Sex differences in the burden of type 2 diabetes and cardiovascular risk across the life course. Amy G. Huebschmann, Rachel R. Huxley, Wendy M. Kohrt, et al. DOI: 10.1007/s00125-019-4939-5.
Developmental undernutrition, offspring obesity and type 2 diabetes. Aryeh D. Stein, Okezi E. Obrutu, Rishikesh V. Behere, et al. DOI: 10.1007/s00125-019-4930-1.
Developmental overnutrition and obesity and type 2 diabetes in offspring. Wei Perng, Emily Oken & Dana Dabelea. DOI: 10.1007/s00125-019-4914-1.
Intrauterine programming of obesity and type 2 diabetes. Denise S. Fernandez-Twinn, Line Hjort, Boris Novakovic, et al. DOI: 10.1007/s00125-019-4951-9.
Paternal impact on the life course development of obesity and type 2 diabetes in the offspring. Gemma C. Sharp & Debbie A. Lawlor. DOI: 10.1007/s00125-019-4919-9.
Environmental neglect: endocrine disruptors as underappreciated but potentially modifiable diabetes risk factors. Robert M. Sargis & Rebecca A. Simmons. DOI: 10.1007/s00125-019-4940-z.
Early-life factors contributing to type 1 diabetes. Maria E. Craig, Ki Wook Kim, Sonia R. Isaacs, et al. DOI: 10.1007/s00125-019-4942-x.
Cellular senescence: at the nexus between ageing and diabetes. Allyson K. Palmer, Birgit Gustafson, James L. Kirkland, et al. DOI: 10.1007/s00125-019-4934-x.
What should governments be doing to prevent diabetes throughout the life course? Patrick Timpel, Lorenz Harst, Doreen Reifegerste, et al. DOI: 10.1007/s00125-019-4941-y.