Structure-Based SAR in the Design of Selective or Bifunctional Nociceptin (NOP) Receptor Agonists Michael E. MeyerArpit DoshiNurulain T. Zaveri Research Article 11 May 2021 Article: 68
There is Only One Valid Definition of Clearance: Critical Examination of Clearance Concepts Reveals the Potential for Errors in Clinical Drug Dosing Decisions Leslie Z. BenetJasleen K. SodhiAli Mesbah Commentary Open access 10 May 2021 Article: 67
Perspectives on Existing and Novel Alternative Intravaginal Probiotic Delivery Methods in the Context of Bacterial Vaginosis Infection Priyadarshini ChandrashekharFarnaz MinooeiJill M. Steinbach-Rankins Review Article 10 May 2021 Article: 66
Estimation of Ontogeny Functions for Renal Transporters Using a Combined Population Pharmacokinetic and Physiology-Based Pharmacokinetic Approach: Application to OAT1,3 Sînziana CristeaElke H. J. KrekelsCatherijne A. J. Knibbe Research Article Open access 04 May 2021 Article: 65
Bioanalysis in the Age of New Drug Modalities Jing ShiXuesong ChenFrancis L.S. Tse Tutorial Open access 03 May 2021 Article: 64
Assessing Treatment Effects with Pharmacometric Models: A New Method that Addresses Problems with Standard Assessments Estelle ChasseloupAdrien TessierMats O. Karlsson Research Article Open access 03 May 2021 Article: 63
A Two-Pore Physiologically Based Pharmacokinetic Model to Predict Subcutaneously Administered Different-Size Antibody/Antibody Fragments Zhe LiXiaoying YuDhaval K. Shah Research Article 03 May 2021 Article: 62
Choroid Plexus and Drug Removal Mechanisms Austin SunJoanne Wang Review Article 03 May 2021 Article: 61
FDA-Industry Scientific Exchange on assessing quantitative systems pharmacology models in clinical drug development: a meeting report, summary of challenges/gaps, and future perspective Jane P. F. BaiBrian J. SchmidtHao Zhu Meeting Report 30 April 2021 Article: 60
Comparison of Canine and Human Physiological Factors: Understanding Interspecies Differences that Impact Drug Pharmacokinetics Marilyn N. MartinezJonathan P. MochelDevendra Pade Review Article 27 April 2021 Article: 59
Comparison of Hepatic Transporter Tissue Expression in Rodents and Interspecies Hepatic OCT1 Activity Bridget L. MorseJohn K. FallonKathleen M. Hillgren Research Article 26 April 2021 Article: 58
Development of a Pediatric Relative Bioavailability/Bioequivalence Database and Identification of Putative Risk Factors Associated With Evaluation of Pediatric Oral Products Gopal PawarFang WuHannah K. Batchelor Research Article Open access 21 April 2021 Article: 57
Quantitative Evaluation of the Effect of Antigen Expression Level on Antibody–Drug Conjugate Exposure in Solid Tumor David BussingSharad SharmaDhaval K. Shah Research Article 15 April 2021 Article: 56
Elucidating the Effect of Fine Lactose Ratio on the Rheological Properties and Aerodynamic Behavior of Dry Powder for Inhalation Ying SunLu QinShirui Mao Research Article 15 April 2021 Article: 55
Clinical Pharmacology Regulatory Sciences in Drug Development and Precision Medicine: Current Status and Emerging Trends Qi LiuMitra AhadpourShiew-Mei Huang Commentary 12 April 2021 Article: 54
Dosing Recommendations for Vancomycin in Children and Adolescents with Varying Levels of Obesity and Renal Dysfunction: a Population Pharmacokinetic Study in 1892 Children Aged 1–18 Years Cornelis SmitSebastiaan C. GouloozeCatherijne A. J. Knibbe Research Article Open access 11 April 2021 Article: 53
A Systematic Review of the Efforts and Hindrances of Modeling and Simulation of CAR T-cell Therapy Ujwani NukalaMarisabel Rodriguez MessanHong Yang Review Article 09 April 2021 Article: 52
Correction to: Insights on Droplet Digital PCR–Based Cellular Kinetics and Biodistribution Assay Support for CAR-T Cell Therapy Hiroshi SugimotoSusan ChenMark G. Qian Correction 31 March 2021 Article: 51
Age-Related Changes in Pediatric Physiology: Quantitative Analysis of Organ Weights and Blood Flows Hsuan Ping ChangSe Jin KimDhaval K. Shah Research Article 31 March 2021 Article: 50
Assessment of Drug Delivery Kinetics to Epidermal Targets In Vivo M. HoppelM. A. M. TabosaR. H. Guy Research Article Open access 29 March 2021 Article: 49
Can Pharmacokinetic Studies Assess the Pulmonary Fate of Dry Powder Inhaler Formulations of Fluticasone Propionate? Günther HochhausMong-Jen ChenJürgen B. Bulitta Research Article 25 March 2021 Article: 48
Assessing Food Effects on Oral Drug Absorption Based on the Degree of Renal Excretion Tao ZhangPeng Zou Research Article 21 March 2021 Article: 47
Parent and Metabolite Concentration-QT Modeling to Evaluate QT-Interval Prolongation at Savolitinib Therapeutic Doses Stein SchalkwijkTarjinder SahotaGhada F. Ahmed Research Article 17 March 2021 Article: 46
An Item Response Theory–Informed Strategy to Model Total Score Data from Composite Scales Gustaf J. WellhagenSebastian UeckertMats O. Karlsson Research Article Open access 16 March 2021 Article: 45