Iontophoresis to Overcome the Challenge of Nail Permeation: Considerations and Optimizations for Successful Ungual Drug Delivery Kevin ChenVinam PuriBozena Michniak-Kohn Review Article 13 January 2021 Article: 25
Human Fetal Liver Metabolism of Oxycodone Is Mediated by CYP3A7 Sara ShumNina Isoherranen Research Article 12 January 2021 Article: 24
Population Pharmacokinetics of Intracellular 5-Fluorouridine 5′-Triphosphate and its Relationship with Hand-and-Foot Syndrome in Patients Treated with Capecitabine Julie M. JanssenBart A. W. JacobsThomas P. C. Dorlo Research Article 08 January 2021 Article: 23
γ-Hydroxybutyric Acid: Pharmacokinetics, Pharmacodynamics, and Toxicology Melanie A. FelmleeBridget L. MorseMarilyn E. Morris Review Article 08 January 2021 Article: 22
A Novel Total Drug Assay for Quantification of Anti-C5 Therapeutic Monoclonal Antibody in the Presence of Abundant Target Hiroo WatanabeMitsuko ShibuyaNaoaki Murao Research Article 07 January 2021 Article: 21
The Role of Alcohol Dehydrogenase in Drug Metabolism: Beyond Ethanol Oxidation Li DiAmanda BalesanoSophia M. Shi Review Article 07 January 2021 Article: 20
Skin Penetration Enhancement Strategies Used in the Development of Melanoma Topical Treatments Supreeda TambunlertchaiSean M. GearyAliasger K. Salem Review Article 06 January 2021 Article: 19
Multiscale and Translational Quantitative Systems Toxicology, Pharmacokinetic-Toxicodynamic Modeling Analysis for Assessment of Doxorubicin-Induced Cardiotoxicity Tanaya R. VaidyaHardik ModySihem Ait-Oudhia Research Article 06 January 2021 Article: 18
Mouse NTCP–Mediated Rosuvastatin Uptake In Vitro and in Slc10a1-Deficient Mice Laura E. RussellMarianne K. DeGorterRichard B. Kim Brief/Technical Note 06 January 2021 Article: 17
Isotyping and Semi-Quantitation of Monkey Anti-Drug Antibodies by Immunocapture Liquid Chromatography-Mass Spectrometry Xiaoxiao HuangXiaobin XuNing Li Research Article Open access 06 January 2021 Article: 16
Application of Model Informed Precision Dosing to Address the Impact of Pregnancy Stage and CYP2D6 Phenotype on Foetal Morphine Exposure Sarah BadaouiAshley M. HopkinsAndrew Rowland Research Article 06 January 2021 Article: 15
Recent Developments on Therapeutic and Diagnostic Approaches for COVID-19 Joydeb MajumderTamara Minko Review Article Open access 05 January 2021 Article: 14
Oil-Immersion Flow Imaging Microscopy for Quantification and Morphological Characterization of Submicron Particles in Biopharmaceuticals Nils KrauseSebastian KuhnTim Menzen Research Article 04 January 2021 Article: 13
Understanding Mechanisms of Food Effect and Developing Reliable PBPK Models Using a Middle-out Approach Xavier J. H. PepinJames E. HuckleArian Emami Riedmaier Research Article 04 January 2021 Article: 12
Spinach and Chive for Kidney Tubule Engineering: the Limitations of Decellularized Plant Scaffolds and Vasculature Katja JansenMarianna EvangelopoulouRosalinde Masereeuw Brief/Technical Note Open access 28 December 2020 Article: 11
Population Pharmacodynamic Modeling Using the Sigmoid Emax Model: Influence of Inter-individual Variability on the Steepness of the Concentration–Effect Relationship. a Simulation Study Johannes H. ProostDouglas J. EleveldMichel M. R. F. Struys Research Article Open access 24 December 2020 Article: 10
Comparison of Precision and Accuracy of Five Methods to Analyse Total Score Data Gustaf J. WellhagenMats O. KarlssonMaria C. Kjellsson Research Article Open access 17 December 2020 Article: 9
Correction to: Drug Absorption Parameters Obtained Using the Isolated Perfused Rat Lung Model Are Predictive of Rat In Vivo Lung Absorption Johanna ErikssonErik SjögrenHelena Thörn Correction 08 December 2020 Article: 8
Correction to: Integrated Multi-stakeholder Systems Thinking Strategy: Decision-making with Biopharmaceutics Risk Assessment Roadmap (BioRAM) to Optimize Clinical Performance of Drug Products Arzu SelenAnette MüllertzTalia Flanagan Correction 03 December 2020 Article: 7
Correction to: Use of Physiologically Based Pharmacokinetic (PBPK) Modeling for Predicting Drug-Food Interactions: an Industry Perspective Arian Emami RiedmaierKevin DeMentNeil Parrott Correction 26 November 2020 Article: 6
Keytruda and PD-L1: a Real-World Example of Co-development of a Drug with a Predictive Biomarker Kenneth Emancipator Review Article 22 November 2020 Article: 5
A Novel Pharmacodynamic Biomarker and Mechanistic Modeling Facilitate the Development of Tovetumab, a Monoclonal Antibody Directed Against Platelet-Derived Growth Factor Receptor Alpha, for Cancer Therapy Meina LiangBing WangLorin Roskos Research Article 18 November 2020 Article: 4
Comparison of the ELISA and ECL Assay for Vedolizumab Anti-drug Antibodies: Assessing the Impact on Pharmacokinetics and Safety Outcomes of the Phase 3 GEMINI Trials Timothy WyantLili YangMaria Rosario Research Article Open access 16 November 2020 Article: 3
Inhalable Nanoparticles/Microparticles of an AMPK and Nrf2 Activator for Targeted Pulmonary Drug Delivery as Dry Powder Inhalers Maria F. AcostaMichael D. AbrahamsonHeidi M. Mansour Research Article Open access 16 November 2020 Article: 2
Albumin-Mediated Uptake Improves Human Clearance Prediction for Hepatic Uptake Transporter Substrates Aiding a Mechanistic In Vitro-In Vivo Extrapolation (IVIVE) Strategy in Discovery Research Na LiAkshay BadrinarayananAnshul Gupta Research Article 16 November 2020 Article: 1