1. Gout: Forgotten therapy for a common disease

   • Bruce N. Cronstein

   Editor’s Commentary Pages: 1 - 2

2. Mechanisms of differential immunogenicity of tumor necrosis factor inhibitors

   • Paul Anderson
   • James Louie
   • Michael Broder

   Invited Commentary Pages: 3 - 9

3. Web alert

   News Pages: 10 - 11

4. State-of-the-art disease-modifying osteoarthritis drugs

   • Roland W. Moskowitz
   • Michele Hooper

   OriginalPaper Pages: 15 - 21

5. How can one develop disease-modifying drugs in osteoarthritis?

   • Maxime Dougados

   OriginalPaper Pages: 22 - 28

6. Considerations in the treatment of early osteoarthritis

   • Senada Arabelovic
   • Timothy E. McAlindon

   OriginalPaper Pages: 29 - 35

7. Quality-of-life issues in osteoporosis

   • Stuart L. Silverman

   OriginalPaper Pages: 39 - 45

8. Premenopausal bone health assessment

   • E. Michael Lewiecki

   OriginalPaper Pages: 46 - 52

9. Treatment of metabolic bone disease in patients with chronic renal disease: A perspective for rheumatologists

   • Paul D. Miller

   OriginalPaper Pages: 53 - 60

10. Combination therapy for osteoporosis: Considerations and controversy

    • Neil Binkley
    • Diane Krueger

    OriginalPaper Pages: 61 - 65

11. Genetics of osteoporosis

    • Huilin Jin
    • Stuart H. Ralston

    OriginalPaper Pages: 66 - 70

12. Oral antiresorptive therapy

    • Ira Pande
    • David J. Hosking

    OriginalPaper Pages: 71 - 77