1. Quantitative imaging of the structural changes of osteoarthritis: An exciting challenge for the new millennium

   • Johanne Martel-Pelletier
   • Jean-Pierre Raynauld
   • Jean-Pierre Pelletier

   Invited Commentary Pages: 465 - 466

2. Web alert

   • Stefano Fiore

   News Pages: 467 - 467

3. Leterature alert

   Abstract Pages: 468 - 469

4. What a difference a year makes: Reflections on the ACR recommendations for the medical management of osteoarthritis

   • Marc C. Hochberg

   OriginalPaper Pages: 473 - 478

5. Diacerein as a disease-modulating agent in osteoarthritis

   • Géraldine Falgarone
   • Maxime Dougados

   OriginalPaper Pages: 479 - 483

6. Erosive osteoarthritis: Presentation, clinical pearls, and therapy

   • George E. Ehrlich

   OriginalPaper Pages: 484 - 488

7. Innovative therapies in osteoarthritis

   • Richard Polisson

   OriginalPaper Pages: 489 - 495

8. Cell biology of osteoarthritis: The chondrocyte’s response to injury

   • Naoshi Fukui
   • Christopher R. Purple
   • Linda J. Sandell

   OriginalPaper Pages: 496 - 505

9. Joint structure modification in osteoarthritis: Development of SMOAD drugs

   • John F. Beary III

   OriginalPaper Pages: 506 - 512

10. Treatment of chronic pain in osteoarthritis: Do opioids have a clinical role?

    • Arthur G. Lipman

    OriginalPaper Pages: 513 - 519

11. Exercise in the treatment of osteoarthritis

    • Basil Clyman

    OriginalPaper Pages: 520 - 523

12. Clinical evidence for osteoarthritis as an inflammatory disease

    • Theodore Pincus

    OriginalPaper Pages: 524 - 534

13. Nitric oxide and inflammatory mediators in the perpetuation of osteoarthritis

    • Steven B. Abramson
    • Mukundan Attur
    • Robert Clancy

    OriginalPaper Pages: 535 - 541