1. Pursuing excellence to build a home for exciting discoveries

   • Xiaofeng Cao

   Message from the Editor-in-Chief 24 December 2022 Pages: 1 - 1

2. SnoRNP is essential for thermospermine-mediated development in Arabidopsis thaliana

   • Xilong Li
   • Zongyun Yan
   • Jiayang Li

   Cover Article 15 November 2022 Pages: 2 - 11

3. RNA therapeutics: updates and future potential

   • Caroline Zhang
   • Biliang Zhang

   Review 08 September 2022 Pages: 12 - 30

4. Structure-based insights into recognition and regulation of SAM-sensing riboswitches

   • Luqian Zheng
   • Qianqian Song
   • Aiming Ren

   Review 29 November 2022 Pages: 31 - 50

5. Genetic lineage tracing identifies cardiac mesenchymal-to-adipose transition in an arrhythmogenic cardiomyopathy model

   • Xinyan Huang
   • Lei Yan
   • Hui Zhang

   Research Paper 27 October 2022 Pages: 51 - 66

6. Identification of two migratory colon ILC2 populations differentially expressing IL-17A and IL-5/IL-13

   • Hongzhi Liu
   • Liang Li
   • Bing Su

   Research Paper 22 July 2022 Pages: 67 - 80

7. The repression of oncoprotein SET by the tumor suppressor p53 reveals a p53-SET-PP2A feedback loop for cancer therapy

   • Han Yao
   • Wenbin Xu
   • Donglai Wang

   Research Paper 21 July 2022 Pages: 81 - 93

8. Overexpressed Cyclin D1 and CDK4 proteins are responsible for the resistance to CDK4/6 inhibitor in breast cancer that can be reversed by PI3K/mTOR inhibitors

   • Zijie Cai
   • Jingru Wang
   • Qiang Liu

   Research Paper 11 August 2022 Pages: 94 - 109

9. Single-cell transcriptomics of immune cells in lymph nodes reveals their composition and alterations in functional dynamics during the early stages of bubonic plague

   • Yifan Zhao
   • Tong Wang
   • Ruifu Yang

   Research Paper 05 August 2022 Pages: 110 - 126

10. Expression of phenylalanine ammonia lyase as an intracellularly free and extracellularly cell surface-immobilized enzyme on a gut microbe as a live biotherapeutic for phenylketonuria

    • Yu Jiang
    • Bingbing Sun
    • Sheng Yang

    Research Paper 28 July 2022 Pages: 127 - 136

11. Quorum sensing-based interactions among drugs, microbes, and diseases

    • Shengbo Wu
    • Shujuan Yang
    • Jianjun Qiao

    Research Paper 04 August 2022 Pages: 137 - 151

12. Structural characterization of SARS-CoV-2 dimeric ORF9b reveals potential fold-switching trigger mechanism

    • Xiyue Jin
    • Xue Sun
    • George F. Gao

    Research Paper 29 September 2022 Pages: 152 - 164

13. An antibody cocktail with broadened mutational resistance and effective protection against SARS-CoV-2

    • Chunyun Sun
    • Hang Chi
    • Liangzhi Xie

    Research Paper 29 September 2022 Pages: 165 - 179

14. Mosquito-borne pathogens hijack human body odors to promote transmission

    • Penghua Wang
    • Gong Cheng

    Insight 04 November 2022 Pages: 180 - 182

15. The genomic, transcriptomic, and immunological profiles of perineural invasion in pancreatic ductal adenocarcinoma

    • Shu-Heng Jiang
    • Rong-Kun Li
    • Zhi-Gang Zhang

    Letter to the Editor 06 July 2022 Pages: 183 - 186

16. Comprehensive analysis of mRNA poly(A) tails by PAIso-seq2

    • Yusheng Liu
    • Hu Nie
    • Jiaqiang Wang

    Letter to the Editor 29 August 2022 Pages: 187 - 190

17. OsDREB1C, an integrator for photosynthesis, nitrogen use efficiency, and early flowering

    • Wei Wang
    • Dong Zhang
    • Chengcai Chu

    Research Highlight 02 September 2022 Pages: 191 - 193

18. New insights from a plant immune receptor may help design of disease resistant crops

    • Jie Zhang
    • Jian-Min Zhou

    Research Highlight 26 September 2022 Pages: 194 - 196