Reversible epigenetic histone modifications and Bdnf expression in neurons with aging and from a mouse model of Alzheimer’s disease Michael P. WalkerFrank M. LaFerlaGregory J. Brewer OriginalPaper 12 January 2012 Pages: 519 - 531
Biological aging alters circadian mechanisms in murine adipose tissue depots Gregory M. SuttonAndrey A. PtitsynJeffrey M. Gimble OriginalPaper 13 March 2012 Pages: 533 - 547
Survivin expression increases during aging and enhances the resistance of aged human fibroblasts to genotoxic stress Huda H. Al-KhalafAbdelilah Aboussekhra OriginalPaper 15 January 2012 Pages: 549 - 562
The role of the T cell in age-related inflammation Richard MacaulayArne N. AkbarSian M. Henson OriginalPaper 15 January 2012 Pages: 563 - 572
A persistent increase in insulin-stimulated glucose uptake by both fast-twitch and slow-twitch skeletal muscles after a single exercise session by old rats Yuanyuan XiaoNaveen SharmaGregory D. Cartee OriginalPaper 29 January 2012 Pages: 573 - 582
Accumulated hippocampal formaldehyde induces age-dependent memory decline Zhiqian TongChanshuai HanRongqiao He OriginalPaper 03 March 2012 Pages: 583 - 596
RETRACTED ARTICLE: Aging decreases rate of docosahexaenoic acid synthesis-secretion from circulating unesterified α-linolenic acid by rat liver Fei GaoAmeer Y. TahaStanley I. Rapoport OriginalPaper 03 March 2012 Pages: 597 - 608
Reversing T cell immunosenescence: why, who, and how Pierre Olivier LangSheila GovindRichard Aspinall OriginalPaper 26 February 2012 Pages: 609 - 620
Exceptionally old mice are highly resistant to lipoxidation-derived molecular damage Lorena ArranzAlba NaudíReinald Pamplona OriginalPaper 25 February 2012 Pages: 621 - 635
Rejuvenating activity of salidroside (SDS): dietary intake of SDS enhances the immune response of aged rats Linlin LuJiangshui YuanShicui Zhang OriginalPaper 26 February 2012 Pages: 637 - 646
Longevity of insulin receptor substrate1 null mice is not associated with increased basal antioxidant protection or reduced oxidative damage Melissa M. PageDominic J. WithersColin Selman OriginalPaper 29 February 2012 Pages: 647 - 658
Melatonin can improve insulin resistance and aging-induced pancreas alterations in senescence-accelerated prone male mice (SAMP8) Sara CuestaRoman KireevJesús A. F. Tresguerres OriginalPaper 13 March 2012 Pages: 659 - 671
Intracellular accumulation of aggregated pyroglutamate amyloid beta: convergence of aging and Aβ pathology at the lysosome Line De KimpeElise S. van HaastertWiep Scheper OriginalPaper Open access 04 April 2012 Pages: 673 - 687
Molecular characterization of the transition to mid-life in Caenorhabditis elegans D. Mark EckleySalim RahimiIlya G. Goldberg OriginalPaper 20 May 2012 Pages: 689 - 703
The interactions of oxidative stress and inflammation with vascular dysfunction in ageing: the vascular health triad Alex J. WadleyJet J. C. S. Veldhuijzen van ZantenSarah Aldred OriginalPaper 28 March 2012 Pages: 705 - 718
Induction of cell proliferation in old rat liver can reset certain gene expression levels characteristic of old liver to those associated with young liver Muhammad A. ChishtiNamik KayaDilek Colak OriginalPaper Open access 04 April 2012 Pages: 719 - 732
Variations in the protein level of Omi/HtrA2 in the heart of aged rats may contribute to the increased susceptibility of cardiomyocytes to ischemia/reperfusion injury and cell death Ke WangJie ZhangHuirong Liu OriginalPaper 26 April 2012 Pages: 733 - 746
MicroRNA-22 increases senescence and activates cardiac fibroblasts in the aging heart Virginija JazbutyteJan FiedlerThomas Thum OriginalPaper Open access 27 April 2012 Pages: 747 - 762
Whole transcriptome sequencing of the aging rat brain reveals dynamic RNA changes in the dark matter of the genome Shona H. WoodThomas CraigJoão Pedro de Magalhães OriginalPaper Open access 04 May 2012 Pages: 763 - 776
Cardiovascular risk in cognitively preserved elderlies is associated with glucose hypometabolism in the posterior cingulate cortex and precuneus regardless of brain atrophy and apolipoprotein gene variations Jaqueline Hatsuko Tamashiro-DuranPaula SquarzoniGeraldo Filho Busatto OriginalPaper 29 April 2012 Pages: 777 - 792
The Drosophila orthologue of progeroid human WRN exonuclease, DmWRNexo, cleaves replication substrates but is inhibited by uracil or abasic sites Penelope A. MasonIvan BoubriakLynne S. Cox OriginalPaper Open access 05 May 2012 Pages: 793 - 806
Blueberry consumption prevents loss of collagen in bone matrix and inhibits senescence pathways in osteoblastic cells Jian ZhangOxana P. LazarenkoJin-Ran Chen OriginalPaper 04 May 2012 Pages: 807 - 820
Aging and substitutive hormonal therapy influence in regional and subcellular distribution of ERα in female rat brain Ana NavarroEva del ValleJorge Tolivia OriginalPaper 10 May 2012 Pages: 821 - 837
Zinc: dietary intake and impact of supplementation on immune function in elderly Eugenio MocchegianiJavier RomeoAscension Marcos OriginalPaper 06 January 2012 Pages: 839 - 860
Limitations to exercise in female centenarians: evidence that muscular efficiency tempers the impact of failing lungs Massimo VenturelliFederico SchenaRussell S. Richardson OriginalPaper 15 January 2012 Pages: 861 - 870
Defining sarcopenia: the impact of different diagnostic criteria on the prevalence of sarcopenia in a large middle aged cohort A. Y. BijlsmaC. G. M. MeskersA. B. Maier OriginalPaper Open access 08 February 2012 Pages: 871 - 881
The impact of obesity on balance control in community-dwelling older women Maxime DutilGrant A. HandriganOlivier Hue OriginalPaper 10 February 2012 Pages: 883 - 890
Neuromuscular adaptations to concurrent training in the elderly: effects of intrasession exercise sequence Eduardo Lusa CadoreMikel IzquierdoLuiz Fernando Martins Kruel OriginalPaper 28 March 2012 Pages: 891 - 903
Cerebral blood flow and cerebrovascular reactivity at rest and during sub-maximal exercise: Effect of age and 12-week exercise training Carissa J. MurrellJames D. CotterPhilip N. Ainslie OriginalPaper 06 June 2012 Pages: 905 - 920
Diet mediates the relationship between longevity and reproduction in mammals Shawn M. WilderDavid G. Le CouteurStephen J. Simpson OriginalPaper 12 January 2012 Pages: 921 - 927
Association of handgrip strength with chronic diseases and multimorbidity Ching-Lung CheungUyen-Sa D. T. NguyenAnnie W. C. Kung OriginalPaper Open access 08 February 2012 Pages: 929 - 941
Association of walking speed in late midlife with mortality: results from the Whitehall II cohort study Alexis ElbazSéverine SabiaArchana Singh-Manoux OriginalPaper Open access 24 February 2012 Pages: 943 - 952
Relative improvements in endurance performance with age: evidence from 25 years of Hawaii Ironman racing Romuald LepersChristoph A. RüstBeat Knechtle OriginalPaper 26 February 2012 Pages: 953 - 962
Immune-endocrine biomarkers as predictors of frailty and mortality: a 10-year longitudinal study in community-dwelling older people D. BaylisD. B. BartlettA. A. Sayer OriginalPaper 03 March 2012 Pages: 963 - 971
Fitness, fatness and survival in elderly populations Jean WooRuby YuForrest Yau OriginalPaper 07 March 2012 Pages: 973 - 984
The inverted CD4/CD8 ratio and associated parameters in 66-year-old individuals: the Swedish HEXA immune study J. StrindhallM. SkogA. Wikby OriginalPaper Open access 14 March 2012 Pages: 985 - 991
Variations of the angiotensin II type 1 receptor gene are associated with extreme human longevity Ariela BenigniSilvia OrisioGiuseppe Remuzzi OriginalPaper 09 May 2012 Pages: 993 - 1005
Relationship between ventilatory function and age in master athletes and a sedentary reference population Hans DegensThomas Mark Maden-WilkinsonJörn Rittweger OriginalPaper 28 April 2012 Pages: 1007 - 1015