News from the National Institute of General Medical Sciences (NIGMS) Michael E. Rogers News Pages: 107 - 107
On the Heterogeneity of Drug Dissolution and Release Panos MacherasAristides Dokoumetzidis Commentary Pages: 108 - 112
Cationic Polymer Based Gene Delivery Systems Stefaan C. De SmedtJoseph DemeesterWim E. Hennink ReviewPaper Pages: 113 - 126
An Isolated In-Situ Rat Head Perfusion Model for Pharmacokinetic Studies Kelley A. FosterGeorge D. MellickMichael S. Roberts OriginalPaper Pages: 127 - 134
Evaluation of Using Dog as an Animal Model to Study the Fraction of Oral Dose Absorbed of 43 Drugs in Humans Win L. ChiouHyun Y. JeongTa C. Wu OriginalPaper Pages: 135 - 140
Microdialysis Technique as a Method to Study the Percutaneous Penetration of Methyl Nicotinate Through Excised Human Skin, Reconstructed Epidermis, and Human Skin In Vivo Esther BoelsmaChris AndersonMaria Ponec OriginalPaper Pages: 141 - 147
Distribution of Gacyclidine Enantiomers in Spinal Cord Extracellular Fluid Guillaume HoizeyMatthieu L. KaltenbachRichard Vistelle OriginalPaper Pages: 148 - 153
Comparison of Zafirlukast (Accolate®) Absorption After Oral and Colonic Administration in Humans Jeff D. FischerMin H. SongKim L. R. Brouwer OriginalPaper Pages: 154 - 159
Application of a Biomagnetic Measurement System (BMS) to the Evaluation of Gastrointestinal Transit of Intestinal Pressure-Controlled Colon Delivery Capsules (PCDCs) in Human Subjects Zhaopeng HuShunsuke MawatariYoshikazu Yosida OriginalPaper Pages: 160 - 167
Hollow Porous Particles in Metered Dose Inhalers Luis A. DellamaryThomas E. TararaJeffry G. Weers OriginalPaper Pages: 168 - 174
Formulation Development and Antitumor Activity of a Filter-Sterilizable Emulsion of Paclitaxel Panayiotis P. ConstantinidesKarel J. LambertSteven C. Quay OriginalPaper Pages: 175 - 182
Dissolution of Hydrocortisone in Human and Simulated Intestinal Fluids Betty Lomstein PedersenHelle BrøndstedHenning Gjelstrup Kristensen OriginalPaper Pages: 183 - 189
Metal-Catalyzed Oxidation of Brain-Derived Neurotrophic Factor (BDNF): Analytical Challenges for the Identification of Modified Sites Jana L. JensenCarl KolvenbachChristian Schöneich OriginalPaper Pages: 190 - 196
Oxidation of the N-Terminal Gly-Residue of Peptides: Stress Study of Pexiganan Acetate in a Drug Formulation Binyamin FeibushBradley C. Snyder OriginalPaper Pages: 197 - 204
Apparent Lack of Effect of P-Glycoprotein on the Gastrointestinal Absorption of a Substrate, Tacrolimus, in Normal Mice Win L. ChiouSang M. ChungTa C. Wu OriginalPaper Pages: 205 - 208
Atorvastatin Transport in the Caco-2 Cell Model: Contributions of P-Glycoprotein and the Proton-Monocarboxylic Acid Co-Transporter Xiaochun WuLloyd R. WhitfieldBarbra H. Stewart OriginalPaper Pages: 209 - 215
Structure Activity Relationship of Human Microsomal Epoxide Hydrolase Inhibition by Amide and Acid Analogues of Valproic Acid Ofer SpiegelsteinDeanna L. KroetzMeir Bialer OriginalPaper Pages: 216 - 221
Nasal Epithelial Permeation of Thymotrinan (TP3) Versus Thymocartin (TP4): Competitive Metabolism and Self-Enhancement M. Christiane SchmidtWerner RubasHans P. Merkle OriginalPaper Pages: 222 - 228
Histone H1-Mediated Transfection: Serum Inhibition Can Be Overcome by Ca2+ Ions Annekathrin HaberlandThomas KnausMichael Böttger OriginalPaper Pages: 229 - 235
Transepithelial Transport of Levofloxacin in the Isolated Perfused Rat Kidney Tatsuya ItoIkuko YanoKen-ichi Inui OriginalPaper Pages: 236 - 241
Development and Characterization of a Rapid and Comprehensive Genotyping Assay to Detect the Most Common Variants in Cytochrome P450 2D6 Lisa A. ScarlettSoraya MadaniRodney J. Y. Ho BriefCommunication Pages: 242 - 246