News from the National Institute of General Medical Sciences (NIGMS) Rochelle M. Long News Pages: 783 - 784
An Interview with a Distinguished Pharmaceutical Scientist: William E. Evans William E. Evans Legacy Pages: 785 - 789
Pharmacodynamics and Toxicodynamics of Drug Action: Signaling in Cell Survival and Cell Death Ah-Ng Tony KongSandhya MandlekarAdedigbo Fasanmande ReviewPaper Pages: 790 - 798
Reversibility of Heat-Induced Denaturation of the Recombinant Human Megakaryocyte Growth and Development Factor Linda O. NarhiJohn S. PhiloTsutomu Arakawa OriginalPaper Pages: 799 - 807
Investigation of Protein-Surfactant Interactions by Analytical Ultracentrifugation and Electron Paramagnetic Resonance: The Use of Recombinant Human Tissue Factor as an Example LaToya S. JonesDavid CipollaTheodore W. Randolph OriginalPaper Pages: 808 - 812
Isolation, Characterization, and Stability of Positional Isomers of Mono-PEGylated Salmon Calcitonins Kang Choon LeeSeung Cheol MoonPatrick P. DeLuca OriginalPaper Pages: 813 - 818
Polymer Molecular Weight Alters Properties of pH-/Temperature-Sensitive Polymeric Beads Chaaya Ramkissoon-GanorkarAnna GutowskaSung Wan Kim OriginalPaper Pages: 819 - 827
Pharmaceutical Dry Powder Aerosols: Correlation of Powder Properties with Dose Delivery and Implications for Pharmacodynamic Effect Neville M. ConcessioMichiel M. VanOortAnthony J. Hickey OriginalPaper Pages: 828 - 834
Differences in Crystallization Behavior Between Quenched and Ground Amorphous Ursodeoxycholic Acid Etsuo YonemochiYutaka InoueKeiji Yamamoto OriginalPaper Pages: 835 - 840
Reduced UV-Induced Degradation of Doxorubicin Encapsulated in Polyethyleneglycol-Coated Liposomes Suzan BandakAvner RamuAlberto Gabizon OriginalPaper Pages: 841 - 846
pH and Osmotic Pressure Inside Biodegradable Microspheres During Erosion1 Anette BrunnerKarsten MäderAchim Göpferich OriginalPaper Pages: 847 - 853
Cyclodextrins as Diethylstilbestrol Carrier System: Characterization of Diethylstilbestrol-Cyclodextrins Complexes Estrella Núñez-DelicadoMar SojoFrancisco García-Carmona OriginalPaper Pages: 854 - 858
Formulation and Lyoprotection of Poly(Lactic Acid-Co-Ethylene Oxide) Nanoparticles: Influence on Physical Stability and In Vitro Cell Uptake Fanny De JaeghereEric AllémannRobert Gurny OriginalPaper Pages: 859 - 866
Enzymatic Degradation of Epichlorohydrin Crosslinked Starch Microspheres by α-Amylase Ghania HamdiGilles Ponchel OriginalPaper Pages: 867 - 875
Polymers with Thiol Groups: A New Generation of Mucoadhesive Polymers? Andreas Bernkop-SchnürchVeronika SchwarzSonja Steininger OriginalPaper Pages: 876 - 881
Drug Liposome Partitioning as a Tool for the Prediction of Human Passive Intestinal Absorption K. BalonB. U. RiebesehlB. W. Müller OriginalPaper Pages: 882 - 888
Synergistic Effect of Formulated Plasmid and Needle-Free Injection for Genetic Vaccines Khursheed AnwerKeith A. EarleAlain P. Rolland OriginalPaper Pages: 889 - 895
Lipid Association Increases the Potency Against Primary Medulloblastoma Cells and Systemic Exposure of l-(2-Chloroethyl)-3-Cyclohexyl-1-Nitrosourea (CCNU) in Rats Claudette BethuneAleksander BlumRodney J. Y. Ho OriginalPaper Pages: 896 - 903
Pravastatin, an HMG-CoA Reductase Inhibitor, Is Transported by Rat Organic Anion Transporting Polypeptide, oatp2 Taro TokuiDaisuke NakaiYuichi Sugiyama OriginalPaper Pages: 904 - 908
Effect of Concentration and Degree of Saturation of Topical Fluocinonide Formulations on In Vitro Membrane Transport and In Vivo Availability on Human Skin Fabian P. SchwarbGeorgios ImanidisChristian Surber OriginalPaper Pages: 909 - 915
Interaction Between Two Dicarboxylate Endogenous Substances, Bilirubin and an Uremic Toxin, 3-Carboxy-4-Methyl-5-Propyl-2-Furanpropanoic Acid, on Human Serum Albumin Yasuhiro TsutsumiToru MaruyamaMasaki Otagiri OriginalPaper Pages: 916 - 923
Relationship Between Etomidate Plasma Concentration and EEG Effect in the Rat Peter De PaepeGert Van HoeyWalter A. Buylaert OriginalPaper Pages: 924 - 929
Venous Irritation, Pharmacokinetics, and Tissue Distribution of Tirilazad in Rats Following Intravenous Administration of a Novel Supersaturated Submicron Lipid Emulsion Youmin WangGebre-Mariam MesfinMichael J. Higgins OriginalPaper Pages: 930 - 938
Evaluation of Truncated Areas in the Assessment of Bioequivalence of Immediate Release Formulations of Drugs with Long Half-Lives and of Cmax with Different Dissolution Rates Pradeep SatheJurgen VenitzLawrence Lesko OriginalPaper Pages: 939 - 943
Prediction of Pharmacokinetic Parameters and the Assessment of Their Variability in Bioequivalence Studies by Artificial Neural Networks Jerneja OparaStanislav PrimožičPolona Cvelbar OriginalPaper Pages: 944 - 948
Dipeptide Derivatives of Primaquine as Transmission-Blocking Antimalarials: Effect of Aliphatic Side-Chain Acylation on the Gametocytocidal Activity and on the Formation of Carboxyprimaquine in Rat Liver Homogenates Maria João PortelaRui MoreiraVirgílio E. do Rosário OriginalPaper Pages: 949 - 955
NO Donor and Biological Properties of Different Benzofuroxans1 Claudio MedanaAntonella Di StiloAmalia Bosia OriginalPaper Pages: 956 - 960
Soft Drugs Based on Hydrocortisone: The Inactive Metabolite Approach and Its Application to Steroidal Antiinflammatory Agents Roy J. LittleNicholas BodorThorsteinn Loftsson OriginalPaper Pages: 961 - 967
Use of 1-Methyl-Pyrrolidone as a Solubilizing Agent for Determining the Uptake of Poorly Soluble Drugs Antje S. UchUlrich HesseJennifer B. Dressman BriefCommunication Pages: 968 - 971
The Leiden/Amsterdam Center for Drug Research will be organizing the following courses: Announcement Pages: 972 - 972