Artificial Neural Network as a Novel Method to Optimize Pharmaceutical Formulations Kozo TakayamaMikito FujikawaTsuneji Nagai ReviewPaper Pages: 1 - 6
Coumarinic Acid-Based Cyclic Prodrugs of Opioid Peptides that Exhibit Metabolic Stability to Peptidases and Excellent Cellular Permeability Olafur S. GudmundssonGiovanni M. PaulettiRonald T. Borchardt OriginalPaper Pages: 7 - 15
Phenylpropionic Acid-Based Cyclic Prodrugs of Opioid Peptides that Exhibit Metabolic Stability to Peptidases and Excellent Cellular Permeation Olafur S. GudmundssonKalpana NimkarRonald T. Borchardt OriginalPaper Pages: 16 - 23
Acyloxyalkoxy-Based Cyclic Prodrugs of Opioid Peptides: Evaluation of the Chemical and Enzymatic Stability as Well as Their Transport Properties Across Caco-2 Cell Monolayers Annette BakOlafur S. GudmundssonRonald T. Borchardt OriginalPaper Pages: 24 - 29
Submicron Cationic Emulsions as a New Delivery System for Oligonucleotides H. TeixeiraC. DubernetP. Couvreur OriginalPaper Pages: 30 - 36
Spleen Capture of Nanoparticles: Influence of Animal Species and Surface Characteristics Marina DemoyJean-Paul AndreuxPatrick Couvreur OriginalPaper Pages: 37 - 41
Penetration Studies of Clotrimazole from Semisolid Formulation Using Step-Scan FT-IR Photoacoustic Spectroscopy Anja SchendzielorzBui Duc HanhSiegfried Wartewig OriginalPaper Pages: 42 - 45
Lateral lontophoretic Solute Transport in Skin Pamela M. LaiYuri G. AnissimovMichael S. Roberts OriginalPaper Pages: 46 - 54
Intestinal Transport of β-Lactam Antibiotics: Analysis of the Affinity at the H+/Peptide Symporter (PEPT1), the Uptake into Caco-2 Cell Monolayers and the Transepithelial Flux Beate BretschneiderMatthias BrandschReinhard Neubert OriginalPaper Pages: 55 - 61
Structure-Transport Relationship for the Intestinal Small-Peptide Carrier: Is the Carbonyl Group of the Peptide Bond Relevant for Transport? Ronald G. SchoenmakersMarco C. StehouwerJosef J. Tukker OriginalPaper Pages: 62 - 68
Intestinal Absorption of Acyclovir β-Glucoside: Comparative Study with Acyclovir, Guanosine, and Kinetin β-Glucoside Takashi MizumaSatoshi MasubuchiShoji Awazu OriginalPaper Pages: 69 - 73
Inhibition of Binding of an Enzymatically Stable Thrombin Inhibitor to Lumenal Proteases as an Additional Mechanism of Intestinal Absorption Enhancement M. SjöströmL. LindforsA.-L. Ungell OriginalPaper Pages: 74 - 79
In Vitro and In Vivo Evaluation of the Enhancing Activity of Glycyrrhizin on the Intestinal Absorption of Drugs Teruko ImaiMichinori SakaiMasaki Otagiri OriginalPaper Pages: 80 - 86
Heterogeneous Tube Model for the Study of Small Intestinal Transit Flow Alkiviadis KalampokisPanos ArgyrakisPanos Macheras OriginalPaper Pages: 87 - 91
The Effect of Oleic Acid on the Human Ileal Brake and Its Implications for Small Intestinal Transit of Tablet Formulations Clair L. DobsonStanley S. DavisIan R. Wilding OriginalPaper Pages: 92 - 96
Surface Activity and Concentration Dependent Intestinal Permeability in the Rat Anders LindahlBengt PerssonHans Lennernäs OriginalPaper Pages: 97 - 102
Analysis of Nonlinear Hepatic Clearance of a Cyclopentapeptide, BQ-123, with the Multiple Indicator Dilution Method Using the Dispersion Model Akihiro HisakaTatsuji NakamuraYuichi Sugiyama OriginalPaper Pages: 103 - 109
Determination of the Rate-Limiting Step in the Hepatic Elimination of YM796 by Isolated Rat Hepatocytes Takafumi IwatsuboHiroshi SuzukiYuichi Sugiyama OriginalPaper Pages: 110 - 116
Pharmacokinetics and Biologic Activity of the Novel Mast Cell Inhibitor, 4-(3′-Hydroxyphenyl)-amino-6,7-dimethoxyquinazoline in Mice Chun-Lin ChenRavi MalaviyaFatih M. Uckun OriginalPaper Pages: 117 - 122
Dependency of Gastrointestinal Toxicity on Release Rate of Tiaprofenic Acid: A Novel Pharmacokinetic-Pharmacodynamic Model Majid VakilyFarhad KhorashehFakhreddin Jamali OriginalPaper Pages: 123 - 129
Use of Truncated Areas to Measure Extent of Drug Absorption in Bioequivalence Studies: Effects of Drug Absorption Rate and Elimination Rate Variability on this Metric Jahnavi KharidiaAndre J. JacksonLarry A. Ouderkirk OriginalPaper Pages: 130 - 134
The Effect of Excipients on the Molecular Mobility of Lyophilized Formulations, as Measured by Glass Transition Temperature and NMR Relaxation-Based Critical Mobility Temperature Sumie YoshiokaYukio AsoShigeo Kojima OriginalPaper Pages: 135 - 140
Molecular Mechanisms of the Adsorption of a Model Protein (Human Serum Albumin) on Poly(Methylidene Malonate 2.1.2) Nanoparticles Yoléne BousquetPieter J. SwartPascal Breton OriginalPaper Pages: 141 - 147
Novel Bioresorbable and Bioeliminable Surfactants for Microsphere Preparation P. BouillotV. BabakE. Dellacherie OriginalPaper Pages: 148 - 154
A Novel Formulation of VIP in Sterically Stabilized Micelles Amplifies Vasodilation In Vivo Hayat ÖnyükselHiroyuki IkezakiIsrael Rubinstein OriginalPaper Pages: 155 - 160
Electrochemical Generation and Interaction Study of the Nitro Radical Anion from Nimesulide J. A. SquellaP. GonzalezL. J. Núñez-Vergara BriefCommunication Pages: 161 - 164
A Comparison of Step-Gradient and Sequential Density Ultracentrifugation and the Use of Lipoprotein Deficient Plasma Controls in Determining the Plasma Lipoprotein Distribution of Lipid-Associated Nystatin and Cyclosporine Kishor M. WasanShawn M. CassidyTak-Yee Lee BriefCommunication Pages: 165 - 169
Accuracy and Precision of Pharmacodynamic Exponent Nancy J. MillenbaughM. Guillaume WientjesJessie L.-S. Au BriefCommunication Pages: 170 - 173