News from the National Institute of General Medical Sciences (NIGMS) Rochelle M. Long News Pages: 1103 - 1103
The Future of Combinatorial Chemistry as a Drug Discovery Paradigm Steven E. Hall Commentary Pages: 1104 - 1105
Flow Cytometry Applications in Pharmacodynamics and Drug Delivery Murali Ramanathan ReviewPaper Pages: 1106 - 1114
Sex Hormones Differentially Regulate Isoforms of UDP-Glucuronosyltransferase Simone I. StrasserSheree A. SmidPaul V. Desmond OriginalPaper Pages: 1115 - 1121
A Population Growth Model of Dissolution Aristides DokoumetzidisPanos Macheras OriginalPaper Pages: 1122 - 1126
Human Intestinal Permeability of Piroxicam, Propranolol, Phenylalanine, and PEG 400 Determined by Jejunal Perfusion Narushi TakamatsuLynda S. WelageGordon L. Amidon OriginalPaper Pages: 1127 - 1132
Pharmacokinetic Model of Ascorbic Acid in Healthy Male Volunteers During Depletion and Repletion James F. GraumlichThomas M. LuddenMark Levine OriginalPaper Pages: 1133 - 1139
Application of Pharmacodynamic Modeling for Designing Time-Variant Dosing Regimens to Overcome Nitroglycerin Tolerance in Experimental Heart Failure John Anthony BauerJoseph P. BalthasarHo-Leung Fung OriginalPaper Pages: 1140 - 1145
Utilization of an Amorphous Form of a Water-Soluble GPIIb/IIIa Antagonist for Controlled Release from Biodegradable Microspheres Shigeyuki TakadaTomofumi KurokawdaYasuaki Ogawa OriginalPaper Pages: 1146 - 1150
Effect of Freezing Rate on the Stability of Liposomes During Freeze-Drying and Rehydration Ewoud C. A. van WindenWei ZhangDaan J. A. Crommelin OriginalPaper Pages: 1151 - 1160
Theory of Force Transducer Design Optimization for Die Wall Stress Measurement During Tablet Compaction: Optimization and Validation of Split-Web Die Using Finite Element Analysis Chuntien YehSyed A. AltafStephen W. Hoag OriginalPaper Pages: 1161 - 1170
Study of Hygroscopic Properties of Aqueous Mixtures of Disodium Fluorescein and Sodium Chloride Using an Electrodynamic Balance Chak K. ChanChin S. KwokAlbert H. L. Chow OriginalPaper Pages: 1171 - 1175
Simultaneous Quantification of an Enantiomer and the Racemic Compound of Ibuprofen by X-ray Powder Diffractometry Neelima V. PhadnisRaj Suryanarayanan OriginalPaper Pages: 1176 - 1180
Effect of Ionic Strength on Solution Stability of PNU-67590A, A Micellar Prodrug of Methylprednisolone Hirokazu OkamotoKiyoko MoriHiroaki Ishii OriginalPaper Pages: 1181 - 1185
ESR Dosimetry of Irradiated Ascorbic Acid J.P. BaslyI. LongyM. Bernard OriginalPaper Pages: 1186 - 1191
Radiation Effects on Dopamine and Norepinephrine J. P. BaslyI. LongyM. Bernard OriginalPaper Pages: 1192 - 1196
N-Trimethyl Chitosan Chloride as a Potential Absorption Enhancer Across Mucosal Surfaces: In Vitro Evaluation in Intestinal Epithelial Cells (Caco-2) Awie R KotzéHenrik L. LueβenHans E. Junginger OriginalPaper Pages: 1197 - 1202
Cellular Retention of Liposome-Delivered Anionic Compounds Modulated by a Probenecid-Sensitive Anion Transporter Yu-Kyoung OhRobert M. Straubinger OriginalPaper Pages: 1203 - 1209
Estimation of the Relative Contribution of the Transcellular and Paracellular Pathway to the Transport of Passively Absorbed Drugs in the Caco-2 Cell Culture Model Vaishali PadeSalomon Stavchansky OriginalPaper Pages: 1210 - 1215
The Absence of Accessible Vitronectin Receptors in Differentiated Tissue Hinders Adenoviral-Mediated Gene Transfer to the Intestinal Epithelium In Vitro Elke WalterMaria A. CroyleGordon L. Amidon OriginalPaper Pages: 1216 - 1222
Enhanced Anti-Inflammatory Effects of Cu, Zn-Superoxide Dismutase Delivered by Genetically Modified Skin Fibroblasts In Vitro and In Vivo Katsuhiko OkumuraKohshi NishiguchiFusao Komada OriginalPaper Pages: 1223 - 1227
Kinetic Analysis of Transcytosis of Epidermal Growth Factor in Madin-Darby Canine Kidney Epithelial Cells Akiko KozuYukio KatoYuichi Sugiyama OriginalPaper Pages: 1228 - 1235
Kinetic Analysis of Tetraethylammonium Transport in the Kidney Epithelial Cell Line, LLC-PK1 Yoshiko TomitaYuko OtsukiKen-ichi Inui OriginalPaper Pages: 1236 - 1240
Perfusion Cells for Studying Regional Variation in Oral-Mucosal Permeability in Humans. I: Kinetic Aspects in Oral-Mucosal Absorption of Alkylparabens Yuji KurosakiKoji VanoToshikiro Kimura OriginalPaper Pages: 1241 - 1245
Polar Solute Transport Across the Pigmented Rabbit Conjunctiva: Size Dependence and the Influence of 8-Bromo Cyclic Adenosine Monophosphate Yoshihide HoribeKen-ichi HosoyaVincent H. L. Lee OriginalPaper Pages: 1246 - 1251
The Effect of Current on Skin Barrier Function In Vivo: Recovery Kinetics Post-Iontophoresis Norris G. TurnerYogeshvar N. KaliaRichard H. Guy OriginalPaper Pages: 1252 - 1257
lontophoretic Delivery Across the Skin: Electroosmosis and Its Modulation by Drug Substances Jouni HirvonenRichard H. Guy OriginalPaper Pages: 1258 - 1263
Biphasic Testosterone Delivery Profile Observed with Two Different Transdermal Formulations Amit MisraRahul PalOm Singh OriginalPaper Pages: 1264 - 1268
Separation and Quantitation of Cationic Liposome Components by High Performance Liquid Chromatography with Evaporative Light-Scattering Detection Jiin H. Felgner Note Pages: 1269 - 1271
Particle Size Distribution of a Suspension Aerosol Using Andersen and Marple-Miller Cascade Impactors Gowdahalli N. Subba RaoDonald W. BanickDaniel M. Pacenti Note Pages: 1272 - 1274
X-ray Scattering Analysis of Human Stratum Corneum Treated by High Voltage Pulses A. JadoulV. RegnierV. Préat Note Pages: 1275 - 1277
Is the Jejunal Permeability in Rats Age-Dependent? Anders LindahlEva KrondahlHans Lennernäs Note Pages: 1278 - 1281
Evaluation of Drug Absorption After Intrapulmonary Administration Using Xenopus Pulmonary Membranes: Correlation with In Vivo Pulmonary Absorption Studies in Rats Shigeki OkumuraHideaki TanakaShozo Muranishi Note Pages: 1282 - 1285