The Effect of pH and Temperature on the Self-Association of Recombinant Human Interleukin-2 as Studied by Equilibrium Sedimentation Siddharth J. AdvantEmory H. BraswellDevendra S. Kalonia OriginalPaper Pages: 637 - 641
Interdomain Interactions in the Chimeric Protein Toxin sCD4(178)-PE40: A Differential Scanning Calorimetry (DSC) Study Stephen R. DavioKathryn M. KienleBrian E. Collins OriginalPaper Pages: 642 - 648
Primary Interactions of Three Quaternary Ammonium Compounds with Blastospores of Candida albicans (MEN Strain) Leo J. SchepDavid S. JonesMax G. Shepherd OriginalPaper Pages: 649 - 652
Antitumor Effect of Arterial Administration of a Medium-Chain Triglyceride Solution of an Angiogenesis Inhibitor, TNP-470, in Rabbits Bearing VX-2 Carcinoma Shigeo YanaiHiroaki OkadaHajime Toguchi OriginalPaper Pages: 653 - 657
Selective Inhibition of Bitter Taste of Various Drugs by Lipoprotein Yoshihisa KatsuragiYoko SugiuraKenzo Kurihara OriginalPaper Pages: 658 - 662
Prolonged Blood Circulation in Rats of Nanospheres Surface-Modified with Semitelechelic Poly[N-(2-Hydroxypropyl)methacrylamide] Shigeru KameiJindřich Kopeček OriginalPaper Pages: 663 - 668
Modelling Mucoadhesion by Use of Surface Energy Terms Obtained from the Lewis Acid–Lewis Base Approach. II. Studies on Anionic, Cationic, and Unionisable Polymers Maria RillosiGraham Buckton OriginalPaper Pages: 669 - 675
Autoradiographic Imaging of the Distribution of 5-Fluorouracil Through Cervical Tissue Following in Vitro Surface Application of a Bioadhesive Cervical Patch A. David WoolfsonDermot F. McCaffertyJohn H. Price OriginalPaper Pages: 676 - 681
Interaction Between Bile Salts and β-Adrenoceptor Antagonists Martin P. GrosvenorJan-Erik Löfroth OriginalPaper Pages: 682 - 686
Enhanced Transdermal Delivery of Diazepam by Submicron Emulsion (SME) Creams Joseph S. SchwarzMichael R. WeisspapirDoron I. Friedman OriginalPaper Pages: 687 - 692
Comparison of Intestinal Permeabilities Determined in Multiple in Vitro and in Situ Models: Relationship to Absorption in Humans Barbra H. StewartO. Helen ChanMichael D. Taylor OriginalPaper Pages: 693 - 699
The Role of Metabolites in Bioequivalency Assessment. II. Drugs with Linear Pharmacokinetics and First-Pass Effect Mei-Ling ChenAndre J. Jackson OriginalPaper Pages: 700 - 708
Monoclonal Digoxin-Specific Antibodies Induce Dose-and Affinity-Dependent Plasma Digoxin Redistribution in Rats Nathalie J. CanoAlain E. SabouraudJean-Michel G. Scherrmann OriginalPaper Pages: 709 - 714
The Distribution of Oleic Acid Between Salbutamol Base Drug and Different Propellant Blends Patrik M. ErikssonKenneth B. SandströmJarl B. Rosenholm OriginalPaper Pages: 715 - 719
Pharmacokinetics of Oral Extended-Release Dosage Forms. I. Release Kinetics, Concentration, and Absorbed Fraction Fang-Yu LiuNancy C. SambolChui Yu Liu OriginalPaper Pages: 720 - 728
Experimental Design and Efficient Parameter Estimation in Preclinical Pharmacokinetic Studies Ene I. EtteCatherine A. HowieBrian Whiting OriginalPaper Pages: 729 - 737
Gradient High Performance Liquid Chromatographic Assay for Degradation Products of Adinazolam Mesylate in a Sustained Release Tablet Formulation Nick L. StemmJohn W. SkougRussell H. Robins OriginalPaper Pages: 738 - 745
Quantitative Microdialysis for Studying the in Vivo L-DOPA Kinetics in Blood and Skeletal Muscle of the Dog Sophie SarreDirk DeleuYvette Michotte OriginalPaper Pages: 746 - 750
The Electrophoretic Mobility of Tripeptides as a Function of pH and Ionic Strength: Comparison with lontophoretic Flux Data Barbara VanOrman HuffGary G. LiversidgeGregory L. McIntire OriginalPaper Pages: 751 - 755
Analysis of Diclofenac and Four of Its Metabolites in Human Urine by HPLC Ronald J. SawchukJill A. MaloneyHenry S. L. Lau OriginalPaper Pages: 756 - 762
Prodrugs to Improve the Oral Bioavailability of a Diacidic Nonpeptide Angiotensin II Antagonist Bruce J. AungstJudy A. BlakeJames R. Pruitt OriginalPaper Pages: 763 - 767
Electrolyte-Induced Changes in Glass Transition Temperatures of Freeze-Concentrated Solutes Lih-Min HerMichael DerasSteven L. Nail OriginalPaper Pages: 768 - 772
Process-Induced Crystallinity Changes in Albuterol Sulfate and Its Effect on Powder Physical Stability Gary H. WardRobert K. Schultz OriginalPaper Pages: 773 - 779
Gastric pH Influences the Appearance of Double Peaks in the Plasma Concentration-Time Profiles of Cimetidine After Oral Administration in Dogs Vanaja MummaneniGordon L. AmidonJennifer B. Dressman OriginalPaper Pages: 780 - 786
Drug Release from Semisolids: Effect of Membrane Permeability on Sensitivity to Product Parameters Joel L. Zatz Note Pages: 787 - 789
Model Features of a Cardiac lontophoretic Drug Delivery Implant Steven P. SchwendemanVinod LabhasetwarRobert J. Levy Note Pages: 790 - 795
Dose-Dependent Brain Delivery of Zidovudine Through the Use of a Zidovudine Chemical Delivery System Marcus E. BrewsterWesley R. AndersonEmil Pop Note Pages: 796 - 798