The Importance of Structural Factors on the Rate and the Extent of N,O-acyl Migration in Cyclic and Linear Peptides Reza OliyaiTeruna J. SiahaanValentine J. Stella OriginalPaper Pages: 323 - 328
Soft Drugs. XX. Design, Synthesis, and Evaluation of Ultra-Short Acting Beta-Blockers Hee-Sun YangWhei-Mei WuNicholas Bodor OriginalPaper Pages: 329 - 336
Crystal Structure of 2-Debenzoyl, 2-Acetoxy Paclitaxel (Taxol®): Conformation of the Paclitaxel Side-Chain Qi GaoJian-Mei WeiShu-Hui Chen OriginalPaper Pages: 337 - 341
Physicochemical Characterization of Parenteral Lipid Emulsion: Determination of Hamaker Constants and Activation Energy of Coalescence Tetsuo YamaguchiKaori NishizakiHiroyuki Ohshima OriginalPaper Pages: 342 - 347
Chemical Pathways of Peptide Degradation. VIII. Oxidation of Methionine in Small Model Peptides by Prooxidant/Transition Metal Ion Systems: Influence of Selective Scavengers for Reactive Oxygen Intermediates Shihong LiChristian SchöneichRonald T. Borchardt OriginalPaper Pages: 348 - 355
The Influence of Regional Deposition on the Pharmacokinetics of Pulmonary-Delivered Human Growth Hormone in Rabbits Paul ColthorpeStephen J. FairGlyn Taylor OriginalPaper Pages: 356 - 359
Transepithelial Transport Properties of Peptidomimetic Thrombin Inhibitors in Monolayers of a Human Intestinal Cell Line (Caco-2) and Their Correlation to in Vivo Data Elke WalterThomas KisselWerner Stüber OriginalPaper Pages: 360 - 365
A Non-Ionic Vesicle Lipid Enhances Mastoparan-Stimulated GTPase Activity of Heterotrimeric G-Proteins Bernd NürnbergRalph HoppeEberhard Nürnberg OriginalPaper Pages: 366 - 369
Tumor Selective Effect of RS-1541 (Palmitoyl-Rhizoxin) in M5076 Sarcoma and Host Tissues in Vivo Taro TokuiNaoyuki MaedaToru Komai OriginalPaper Pages: 370 - 375
The Description of the Gastrointestinal Transit of Pellets Assessed by Gamma Scintigraphy Using Statistical Moments Fridrun PodczeckJohn Michael NewtonKay-Hay Yuen OriginalPaper Pages: 376 - 379
The Application of Malononitriles as Microviscosity Probes in Pharmaceutical Systems Sherry L. LaPorteAbizer HarianawalaRobin H. Bogner OriginalPaper Pages: 380 - 386
Drug Delivery Studies in Caco-2 Monolayers. Synthesis, Hydrolysis, and Transport of O-Cyclopropane Carboxylic Acid Ester Prodrugs of Various β-Blocking Agents Lars HovgaardHelle BrøndstedHans Bundgaard OriginalPaper Pages: 387 - 392
The Effect of Different Concentrations of Mannitol in Solution on Small Intestinal Transit: Implications for Drug Absorption Dawn A. AdkinStanley S. DavisIan R. Wilding OriginalPaper Pages: 393 - 396
In Vitro and in Vivo Evaluation of Mucoadhesive Microspheres Prepared for the Gastrointestinal Tract Using Polyglycerol Esters of Fatty Acids and a Poly(acrylic acid) Derivative Yohko AkiyamaNaoki NagaharaHajime Toguchi OriginalPaper Pages: 397 - 405
Neural Network Predicted Peak and Trough Gentamicin Concentrations Michael E. BrierJacek M. ZuradaGeorge R. Aronoff OriginalPaper Pages: 406 - 412
A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability Gordon L. AmidonHans LennernäsJohn R. Crison OriginalPaper Pages: 413 - 420
Analysis of Tissue Distribution of Valproate in Guinea-Pigs: Evidence for Its Capacity-Limited Tissue Distribution Hsiu-Ying YuYu-Zen Shen OriginalPaper Pages: 421 - 425
Regional Rectal Perfusion: A New in Vivo Approach to Study Rectal Drug Absorption in Man Hans LennernäsUrban FagerholmRoger Hällgren OriginalPaper Pages: 426 - 432
A Compartmental Model for the Ocular Pharmacokinetics of Cyclosporine in Rabbits Clifford OhBradley A. SavilleDavid S. Rootman OriginalPaper Pages: 433 - 437
Pharmacodynamic Analysis of Analgesic Clinical Trials Using Empirical Methods Chui Yu LiuNancy C. Sambol OriginalPaper Pages: 438 - 445
Second Derivative Infrared Spectroscopy as a Non-Destructive Tool to Assess the Purity and Structural Integrity of Proteins D. Michael BylerRachel M. WilsonTheodore D. Sokoloski OriginalPaper Pages: 446 - 450
Stabilization of Human Epidermal Growth Factor (hEGF) in Aqueous Formulation Kyonghee SonChanghyuk Kwon Note Pages: 451 - 454
Functional Evaluation of Anchored Skin Equivalent Cultured in Vitro: Percutaneous Absorption Studies and Lipid Analysis Martine MichelLucie GermainFrançois A. Auger Note Pages: 455 - 458
Pharmacodynamic Modeling of Prednisolone Effects on Natural Killer Cell Trafficking Zhi-Xin XuMi-Jeong LeeWilliam J. Jusko Note Pages: 459 - 463