Use of Stable Isotopes for Evaluation of Drug Delivery Systems: Comparison of Ibuprofen Release in Vivo and in Vitro from Two Biphasic Release Formulations Utilizing Different Rate-Controlling Polymers Don L. TheisLeo J. LucisanoGordon W. Halstead OriginalPaper Pages: 1069 - 1076
Chemical Stability of Ethyl Icosapentate Against Autoxidation. II. Effect of Photoirradiation on Oxidation Kinetics Reiko TeraokaMakoto OtsukaYoshihisa Matsuda OriginalPaper Pages: 1077 - 1081
Synthesis and in Vitro Study of a Diglyceride Prodrug of a Peptide Florence DeliePatrick CouvreurYves Letourneux OriginalPaper Pages: 1082 - 1087
Conformation of Amiodarone · HC1: A Solution and Solid State 13C-NMR Study Renée C. RaoFrédéric LefebvreMichel Gachon OriginalPaper Pages: 1088 - 1092
Evaluation of Solubilizers in the Drug Release Testing of Hydrophilic Matrix Extended-Release Tablets of Felodipine Bertil AbrahamssonDick JohanssonKarin Wingstrand OriginalPaper Pages: 1093 - 1097
An Improved Microscope Stage for Direct Observation of Freezing and Freeze Drying Steven L. NailLih-Min HerLisa L. Nail OriginalPaper Pages: 1098 - 1100
Pulmonary Delivery of Powders and Solutions Containing Recombinant Human Granulocyte Colony-Stimulating Factor (rhG-CSF) to the Rabbit Ralph W. NivenFred D. LottJudith M. Cribbs OriginalPaper Pages: 1101 - 1109
Novel Delivery of Antioxidant Enzyme Catalase to Alveolar Macrophages by Fc Receptor-Mediated Endocytosis Jeannine HarrisonXianglin ShiYongyut Rojanasakul OriginalPaper Pages: 1110 - 1114
Stability of Acyl Derivatives of Insulin in the Small Intestine: Relative Importance of Insulin Association Characteristics in Aqueous Solution Hiroyuki AsadaTakayuki DouenShozo Muranishi OriginalPaper Pages: 1115 - 1120
Receptor-Mediated Peptide Delivery in Pulmonary Epithelial Monolayers Deepa DeshpandeDavid Toledo-VelasquezYongyut Rojanasakul OriginalPaper Pages: 1121 - 1126
Comparison of Cell Proliferation and Toxicity Assays Using Two Cationic Liposomes Katriina LappalainenIlpo JääskeläinenStina Syrjänen OriginalPaper Pages: 1127 - 1131
Intestinal Permeability Enhancement: Efficacy, Acute Local Toxicity, and Reversibility E. Scott SwensonWilliam B. MilisenWilliam Curatolo OriginalPaper Pages: 1132 - 1142
Preparation of Three-Month Depot Injectable Microspheres of Leuprorelin Acetate Using Biodegradable Polymers Hiroaki OkadaYayoi DokenHajime Toguchi OriginalPaper Pages: 1143 - 1147
Effect of Medium-Chain Glycerides on Physiological Properties of Rabbit Intestinal Epithelium in Vitro Ping-Yang YehPhilip L. SmithHarma Ellens OriginalPaper Pages: 1148 - 1154
Characterization of Esterase and Alcohol Dehydrogenase Activity in Skin. Metabolism of Retinyl Palmitate to Retinol (Vitamin A) During Percutaneous Absorption James BoehnleinAdel SakrRobert L. Bronaugh OriginalPaper Pages: 1155 - 1159
Uptake of Nanoparticles by Rat Glomerular Mesangial Cells in Vivo and in Vitro Luc ManilJean-Claude DavinPhilippe Mahieu OriginalPaper Pages: 1160 - 1165
Non-Isothermal and Isothermal Crystallization of Sucrose from the Amorphous State Azita Saleki-GerhardtGeorge Zografi OriginalPaper Pages: 1166 - 1173
Cyclodextrins as Mucosal Absorption Promoters of Insulin. II. Effects of β-Cyclodextrin Derivatives on α-Chymotryptic Degradation and Enteral Absorption of Insulin in Rats Zezhi ShaoYuping LiAshim K. Mitra OriginalPaper Pages: 1174 - 1179
Enhanced Delivery and Antitumor Activity of Doxorubicin Using Long-Circulating Thermosensitive Liposomes Containing Amphipathic Polyethylene Glycol in Combination with Local Hyperthermia Sakae UnezakiKazuo MaruyamaMotoharu Iwatsuru OriginalPaper Pages: 1180 - 1185
Chitosan as a Novel Nasal Delivery System for Peptide Drugs Lisbeth IllumNidal F. FarrajStanley S. Davis OriginalPaper Pages: 1186 - 1189
A Modified Product Inhibition Model Describes the Nonlinear Pharmacokinetics of Nicorandil in Rats Elizabeth L. BachertZhuang-wu LiHo-Leung Fung OriginalPaper Pages: 1190 - 1198
Sustained Suppression of the Pituitary-Gonadal Axis by Leuprorelin Three-Month Depot Microspheres in Rats and Dogs Hiroaki OkadaYayoi DokenHajime Toguchi OriginalPaper Pages: 1199 - 1203
Phenobarbital Disposition in Adult and Neonatal Rabbits Sun Dong YooDavid E. BurgioPatrick J. McNamara Note Pages: 1204 - 1206
Study of the Interaction Between β-Cyclodextrin and Chlorhexidine Hong QiToshiaki NishihataJ. Howard Rytting Note Pages: 1207 - 1210
Synthesis of Novel Aminopropylguanidine Derivatives with Potential Antihypertensive Activity Unsal CalisJohn R. FinchGeorge A. Digenis Note Pages: 1211 - 1215
Workshop III Report: Scaleup of Liquid and Semisolid Disperse Systems G. A. Van BuskirkV. P. ShahJ. L. Zatz Legacy Pages: 1216 - 1220
Normal Volunteers Should Not Be Used for Bioavailability or Bioequivalence Studies of Clozapine Rolf PokornyMarion J. FinkelWilliam T. Robinson Letter to the Editor Pages: 1221 - 1221
2ND EUROPEAN CONGRESS OF PHARMACEUTICAL SCIENCES EIGHTH ANNUAL PHARMACOKINETICS COURSE FOR PHARMACEUTICAL SCIENTISTS ONE-WEEK WORKSHOP ON ADVANCED METHODS IN PHARMACOKINETICS Announcement Pages: 1222 - 1222