1. Heterogeneity of Breast Cancer among Patients and Implications for Patient Selection for Adjuvant Chemotherapy

   • Fabrice Andre
   • Lajos Pusztai

   Expert Review 12 August 2006 Pages: 1951 - 1958

2. Lipid Injectable Emulsions: Pharmacopeial and Safety Issues

   • David F. Driscoll

   Expert Review 09 August 2006 Pages: 1959 - 1969

   

3. Co-Expression of Vascular Endothelial Growth Factor and Interleukin-1 Receptor Antagonist Improves Human Islet Survival and Function

   • Ajit S. Narang
   • Omaima Sabek
   • Ram I. Mahato

   Featured Article 12 August 2006 Pages: 1970 - 1982

   

4. Intra- and Inter-ethnic Differences in the Allele Frequencies of Cytochrome P450 2B6 Gene in Chinese

   • Su Guan
   • Min Huang
   • Shu-Feng Zhou

   Short Communication 09 August 2006 Pages: 1983 - 1990

   

5. Metabolic and Efflux Properties of Caco-2 Cells Stably Transfected with Nuclear Receptors

   • Timo Korjamo
   • Jukka Mönkkönen
   • Paavo Honkakoski

   Research Paper 09 August 2006 Pages: 1991 - 2001

   

6. Near-Infrared Imaging for Studying Homogeneity of Protein-Sugar Mixtures

   • Nataša Jovanović
   • Ad Gerich
   • Wim Jiskoot

   Research Paper 12 August 2006 Pages: 2002 - 2013

   

7. Population Pharmacokinetic/Pharmacodynamic Modelling of the Analgesic Effects of Tramadol in Pediatrics

   • María J. Garrido
   • Walid Habre
   • Iñaki F. Trocóniz

   Research Paper 09 August 2006 Pages: 2014 - 2023

   

8. Monitoring of In Vitro Fat Digestion by Electron Paramagnetic Resonance Spectroscopy

   • Andrea Rübe
   • Sandra Klein
   • Karsten Mäder

   Research Paper 10 August 2006 Pages: 2024 - 2029

   

9. Predicting Plutonium Decorporation Efficacy after Intravenous Administration of DTPA Formulations: Study of Pharmacokinetic–Pharmacodynamic Relationships in Rats

   • Guillaume Phan
   • Béatrice Le Gall
   • Henri Bénech

   Research Paper 09 August 2006 Pages: 2030 - 2035

   

10. Metrics for External Model Evaluation with an Application to the Population Pharmacokinetics of Gliclazide

    • Karl Brendel
    • Emmanuelle Comets
    • France Mentré

    Research Paper 12 August 2006 Pages: 2036 - 2049

    

11. Application of Clinical Trial Simulation to Compare Proof-of-Concept Study Designs for Drugs with a Slow Onset of Effect; An Example in Alzheimer's Disease

    • Peter Lockwood
    • Wayne Ewy
    • Nick Holford

    Research Paper 12 August 2006 Pages: 2050 - 2059

    

12. The Absorption of Darbepoetin Alfa Occurs Predominantly via the Lymphatics Following Subcutaneous Administration to Sheep

    • Danielle N. McLennan
    • Christopher J. H. Porter
    • Susan A. Charman

    Research Paper 09 August 2006 Pages: 2060 - 2066

    

13. Alterations in Neuronal Transport but not Blood-Brain Barrier Transport are Observed during Gamma-Hydroxybutyrate (GHB) Sedative/Hypnotic Tolerance

    • Indranil Bhattacharya
    • Joseph J. Raybon
    • Kathleen M. K. Boje

    Research Paper 10 August 2006 Pages: 2067 - 2077

    

14. Porcine Alveolar Epithelial Cells in Primary Culture: Morphological, Bioelectrical and Immunocytochemical Characterization

    • Anne Steimer
    • Michael Laue
    • Claus-Michael Lehr

    Research Paper 09 August 2006 Pages: 2078 - 2093

    

15. Inhalation Delivery and Anti-tumor Activity of Celecoxib in Human Orthotopic Non-Small Cell Lung Cancer Xenograft Model

    • Suniket V. Fulzele
    • Abhijit Chatterjee
    • Mandip Singh

    Research Paper 11 August 2006 Pages: 2094 - 2106

    

16. Increased Transport of Resveratrol Across Monolayers of the Human Intestinal Caco-2 Cells is Mediated by Inhibition and Saturation of Metabolites

    • Alexandra Maier-Salamon
    • Birgit Hagenauer
    • Walter Jäger

    Research Paper 09 August 2006 Pages: 2107 - 2115

    

17. Improving the Oral Efficacy of Recombinant Granulocyte Colony-Stimulating Factor and Transferrin Fusion Protein by Spacer Optimization

    • Yun Bai
    • Wei-Chiang Shen

    Research Paper 09 August 2006 Pages: 2116 - 2121

    

18. Effects of Sodium Taurocholate on the Absorption of Inhaled ^99mTc-DTPA

    • Eva Bondesson
    • Thomas Bengtsson
    • Per Wollmer

    Research Paper 11 August 2006 Pages: 2122 - 2128

    

19. Molecular Properties of Flurbiprofen and its Solid Dispersions with Eudragit RL100 Studied by High- and Low-Resolution Solid-State Nuclear Magnetic Resonance

    • Giulia Mollica
    • Marco Geppi
    • Carlo A. Veracini

    Research Paper 09 August 2006 Pages: 2129 - 2140

    

20. Chemical Analysis of Solid-State Irradiated Human Insulin

    • Hélène Terryn
    • Jean-Paul Vanhelleputte
    • Bernard Tilquin

    Research Paper 09 August 2006 Pages: 2141 - 2148

    

21. Calculation of the Penetration Depth of X-rays in Intact Pharmaceutical Film-Coated Tablets by Microdiffractometory

    • Hiroyuki Yamada
    • Raj Suryanarayanan

    Research Paper 12 August 2006 Pages: 2149 - 2157

    

22. Comparative Relaxation Dynamics of Glucose and Maltitol

    • Sergey Vyazovkin
    • Ion Dranca

    Research Paper 09 August 2006 Pages: 2158 - 2164

    

23. Use of a Dynamic in Vitro Lipolysis Model to Rationalize Oral Formulation Development for Poor Water Soluble Drugs: Correlation with in Vivo Data and the Relationship to Intra-Enterocyte Processes in Rats

    • Arik Dahan
    • Amnon Hoffman

    Research Paper 11 August 2006 Pages: 2165 - 2174

    

24. Non-Competitive Inhibitory Activities of Morphinan and Morphine Derivatives at the α3β4 Neuronal Nicotinic Acetylcholine Receptor Determined Using Nonlinear Chromatography and Chemometric Techniques

    • Krzysztof Jozwiak
    • Ruin Moaddel
    • Irving W. Wainer

    Research Paper 09 August 2006 Pages: 2175 - 2182

    

25. Development of a Novel Method for the Preparation of Thiolated Polyacrylic Acid Nanoparticles

    • Melanie Greindl
    • Andreas Bernkop-Schnürch

    Research Paper 09 August 2006 Pages: 2183 - 2189

    

26. Pegylated Nanocapsules Produced by an Organic Solvent-Free Method: Evaluation of their Stealth Properties

    • Arnaud Béduneau
    • Patrick Saulnier
    • Jean-Pierre Benoit

    Research Paper 09 August 2006 Pages: 2190 - 2199

    

27. Correlation between Inertial Impaction and Laser Diffraction Sizing Data for Aerosolized Carrier-based Dry Powder Formulations

    • Xian-Ming Zeng
    • Helen B. MacRitchie
    • Gary P. Martin

    Research Paper 10 August 2006 Pages: 2200 - 2209

    

28. Characterisation of a Carrier-Free Dry Powder Aerosol Formulation Using Inertial Impaction and Laser Diffraction

    • Gary P. Martin
    • Helen B. MacRitchie
    • Xian-Ming Zeng

    Research Paper 10 August 2006 Pages: 2210 - 2219

    

29. Micronization of Insulin by High Pressure Homogenization

    • Angelika Maschke
    • Nadia Calí
    • Achim Göpferich

    Research Paper 12 August 2006 Pages: 2220 - 2229

    

30. AAPS Update

    Announcement 19 August 2006 Pages: 2230 - 2231