Volume 2, Issue 3

Perspectives in Drug Discovery and Design is now archived and no longer receiving submissions with this publisher. All articles published in the journal during its time with Springer will remain fully searchable through our websites.

Search all Perspectives in Drug Discovery and Design articles

July 1995

14 articles in this issue

Proteases as therapeutic targets
Charles S. Craik
Christine Debouek
Editorial Pages: 327 - 328
Aspartic proteinases: The structures and functions of a versatile superfamily of enzymes
Kunchur Guruprasad
Venugopal Dhanaraj
Tom L. Blundell
Perspectives Part I. Eucaryotic Host Proteases Pages: 329 - 341
Matrix metalloproteases: Structure-based drug discovery targets
Michelle F. Browner
Perspectives Part I. Eucaryotic Host Proteases Pages: 343 - 351
Proteolytic maturation of transforming growth factor-α
Erika Cappelluti
Robert B. Harris
Perspectives Part I. Eucaryotic Host Proteases Pages: 353 - 361
The metabolism of the amyloid precursor protein and its relevance to Alzheimer's disease
Sukanto Sinha
Perspectives Part I. Eucaryotic Host Proteases Pages: 363 - 369
Cysteine proteases and tumor progression
Isabelle M. Berquin
Bonnie F. Sloane
Perspectives Part I. Eucaryotic Host Proteases Pages: 371 - 388
Interleukin-1β-converting enzyme and related proteases as potential targets in inflammation and apoptosis
Nancy A. Thornberry
Douglas K. Miller
Donald W. Nicholson
Perspectives Part I. Eucaryotic Host Proteases Pages: 389 - 399
The role of metalloproteinases and their inhibitors in regulating mammary epithelial morphology and function in vivo
Carolyn J. Sympson
Rabih S. Talhouk
Zena Werb
Perspectives Part I. Eucaryotic Host Proteases Pages: 401 - 411
Assemblin, a herpes virus serine maturational proteinase and new molecular target for antivirals
Wade Gibson
Anthony R. Welch
Matthew R. T. Hall
Perspectives Part II. Viral, Parasitic And Microbial Proteases Pages: 413 - 426
Progress in the discovery of orally bioavailable inhibitors of HIV protease
Dale J. Kempf
Perspectives Part II. Viral, Parasitic And Microbial Proteases Pages: 427 - 436
Cysteine proteases of parasites: A remarkable diversity of function
James H. McKerrow
Perspectives Part II. Viral, Parasitic And Microbial Proteases Pages: 437 - 444
Host andPorphyromonas gingivalis proteinases in periodontitis: A biochemical model of infection and tissue destruction
Jan Potempa
Robert Pike
Jim Travis
Perspectives Part II. Viral, Parasitic And Microbial Proteases Pages: 445 - 458
Structural aspects of the serpin reaction coordinate
Darin S. Katz
David W. Christianson
Perspectives Part III. Macromolecular Protease Inhibitors Pages: 459 - 474
Ecotin: A most adaptable protease inhibitor
Sarah A. Gillmor
Mary E. McGrath
Robert J. Fletterick
Perspectives Part III. Macromolecular Protease Inhibitors Pages: 475 - 482

Volume 2, Issue 3

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