1. Preface

   EditorialNotes Pages: 1 - 1

2. Dedication

   Announcement Pages: 1 - 2

3. Poly(ADP-ribose): Historical perspective

   • Takashi Sugimura
   • Masanao Miwa

   Part I: Historical Perspective Pages: 5 - 12

4. Structure and function of poly(ADP-ribose) polymerase

   • Gilbert de Murcia
   • Valérie Schreiber
   • Josiane Ménissier de Murcia

   Part II: Poly(ADP-ribosyl)ation Pages: 15 - 24

5. Poly(ADP-ribose) polymerase: Structural conservation among different classes of animals and its implications

   • Kazuhiko Uchida
   • Masanao Miwa

   Part II: Poly(ADP-ribosyl)ation Pages: 25 - 32

6. Enzymology of ADP-ribose polymer synthesis

   • Rafael Alvarez-Gonzalez
   • Gustavo Pacheco-Rodriguez
   • Hilda Mendoza-Alvarez

   Part II: Poly(ADP-ribosyl)ation Pages: 33 - 37

7. Interaction of poly(ADP-ribose)polymerase with DNA polymerase α

   • Shonen Yoshida
   • Cynthia Marie G. Simbulan

   Part II: Poly(ADP-ribosyl)ation Pages: 39 - 44

8. Poly(ADP-ribose) catabolism in mammalian cells

   • Jean Lagueux
   • Girish M. Shah
   • Guy G. Poirier

   Part II: Poly(ADP-ribosyl)ation Pages: 45 - 52

9. Histone shuttling by poly ADP-ribosylation

   • Felix R. Althaus
   • Liane Höfferer
   • Claudio A. Realini

   Part II: Poly(ADP-ribosyl)ation Pages: 53 - 59

10. Growth-phase-dependent response to DNA damage in poly(ADP-ribose) polymerase deficient cell lines: basis for a new hypothesis describing the role of poly(ADP-ribose) polymerase in DNA replication and repair

    • Satadal Chatterjee
    • Nathan A. Berger

    Part II: Poly(ADP-ribosyl)ation Pages: 61 - 69

11. The function of poly (ADP-ribosylation) in DNA breakage and rejoining

    • Sydney Shall

    Part II: Poly(ADP-ribosyl)ation Pages: 71 - 75

12. Poly(ADP-ribose) polymerase gene on chromosome 1q: Early role in differentiation linked replication; gene on human chromosome 13q: Marker of carcinogenesis

    • Mark E. Smulson

    Part II: Poly(ADP-ribosyl)ation Pages: 77 - 84

13. Poly(ADP-ribose) polymerase activity in intact or permeabilized leukocytes from mammalian species of different longevity

    • Alexander Bürkle
    • Marcus Müller
    • Jan-Heiner Küpper

    Part II: Poly(ADP-ribosyl)ation Pages: 85 - 90

14. ADP-ribosylation and gene expression

    • Peter Zahradka
    • Lorraine Yau

    Part II: Poly(ADP-ribosyl)ation Pages: 91 - 98

15. Transcriptional regulation and autoregulation of the human gene for ADP-ribosyltransferase

    • Shiao Li Oei
    • Herbert Herzog
    • Manfred Schweiger

    Part II: Poly(ADP-ribosyl)ation Pages: 99 - 104

16. Vertebrate mono-ADP-ribosyltransferases

    • Anna Zolkiewska
    • Ian J. Okazaki
    • Joel Moss

    Part III Mono(ADP-ribosylation) Pages: 107 - 112

17. Target protein for eucaryotic arginine-specific ADP-ribosyltransferase

    • Mikako Tsuchiya
    • Makoto Shimoyama

    Part III Mono(ADP-ribosylation) Pages: 113 - 118

18. ADP-ribosylarginine hydrolases

    • Tatsuyuki Takada
    • Ian J. Okazaki
    • Joel Moss

    Part III Mono(ADP-ribosylation) Pages: 119 - 122

19. Reversible ADP-ribosylation as a mechanism of enzyme regulation in procaryotes

    • Paul W. Ludden

    Part III Mono(ADP-ribosylation) Pages: 123 - 129

20. Cellular ADP-ribosylation of Elongation Factor 2

    • Wallace J. Iglewski

    Part III Mono(ADP-ribosylation) Pages: 131 - 133

21. Characterization of botulinum C3-catalyzed ADP-ribosylation ofrho proteins and identification of mammalian C3-like ADP-ribosyltransferase

    • Tomohiko Maehama
    • Nobuyuki Sekine
    • Toshiaki Katada

    Part III Mono(ADP-ribosylation) Pages: 135 - 140

22. ADP-ribosylation of the molecular chaperone GRP78/BiP

    • Barry E. Ledford
    • Gregory H. Leno

    Part III Mono(ADP-ribosylation) Pages: 141 - 148

23. Diphtheria toxin-related cytokine fusion proteins: elongation factor 2 as a target for the treatment of neoplastic disease

    • Johanna vander Spek
    • Larry Cosenza
    • John R. Murphy

    Part IV: Toxin Mono-ADP-ribosylation Pages: 151 - 156

24. ADP-ribosylation factors: a family of ∼20-kDa guanine nucleotide-binding proteins that activate cholera toxin

    • Catherine F. Welsh
    • Joel Moss
    • Martha Vaughan

    Part IV: Toxin Mono-ADP-ribosylation Pages: 157 - 166

25. Clostridial ADP-ribosylating toxins: effects on ATP and GTP-binding proteins

    • Klaus Aktories

    Part IV: Toxin Mono-ADP-ribosylation Pages: 167 - 176

26. Common structure of the catalytic sites of mammalian and bacterial toxin ADP-ribosyltransferases

    • Ian J. Okazaki
    • Joel Moss

    Part IV: Toxin Mono-ADP-ribosylation Pages: 177 - 181

27. Inhibitors and activators of ADP-ribosylation reactions

    • Marek Banasik
    • Kunihiro Ueda

    Part V: Inhibitors and Activators of ADP-ribosylation Pages: 185 - 197

28. Nitric oxide and NAD-dependent protein modification

    • Lee J. McDonald
    • Joel Moss

    Part VI: Derivation of Proteins with ADP-ribose, NAD and their Analogues Pages: 201 - 206

29. Glycation of proteins by ADP-ribose

    • Elaine L. Jacobson
    • Daniel Cervantes-Laurean
    • Myron K. Jacobson

    Part VI: Derivation of Proteins with ADP-ribose, NAD and their Analogues Pages: 207 - 212

30. DeoxyNAD and deoxyADP-ribosylation of proteins

    • Rafael Alvarez-Gonzalez

    Part VI: Derivation of Proteins with ADP-ribose, NAD and their Analogues Pages: 213 - 219

31. Enzymatic and nonenzymatic ADP-ribosylation of cysteine

    • Lee J. McDonald
    • Joel Moss

    Part VI: Derivation of Proteins with ADP-ribose, NAD and their Analogues Pages: 221 - 226

32. Cyclic ADP-ribose: A calcium mobilizing metabolite of NAD⁺

    • Hon Cheung Lee

    Part VII Cyclic ADP-ribose, NAD Hydrologis and ADP-ribose Synthesis Pages: 229 - 235

33. NAD Glycohydrolases: A possible function in calcium homeostasis

    • Hyuntae Kim
    • Elaine L. Jacobson
    • Myron K. Jacobson

    Part VII Cyclic ADP-ribose, NAD Hydrologis and ADP-ribose Synthesis Pages: 237 - 243

34. NAD hydrolysis: Chemical and enzymatic mechanisms

    • Norman J. Oppenheimer

    Part VII Cyclic ADP-ribose, NAD Hydrologis and ADP-ribose Synthesis Pages: 245 - 251