1. Editorial

   • M. J. Parnham

   EditorialNotes Pages: 3 - 3

2. Ten years research on inflammation revisited

   • K. Brune

   Anniversary Lectures Pages: 4 - 8

3. Molecular events in the activation of murine macrophages

   • R. J. Uhing
   • D. O. Adams

   Anniversary Lectures Pages: 9 - 14

4. Control of humoral immune responses by arachidonic acid metabolites

   • T. W. Behrens
   • J. S. Goodwin

   Anniversary Lectures Pages: 15 - 21

5. Allergy or inflammation? From neuropeptide stimulation of human skin mast cells to studies on the mechanism of the late asthmatic response

   • M. K. Church
   • R. C. Benyon
   • S. T. Holgate

   Mediators of Hypersensitivity Reactions Pages: 22 - 30

6. Lung inflammation, its significance for asthma therapy

   • J. Morley
   • D. Smith

   Mediators of Hypersensitivity Reactions Pages: 31 - 39

7. Histamine determination in the blood during the immediate asthmatic response (IAR)

   • Z. Pelikan

   Mediators of Hypersensitivity Reactions Pages: 40 - 41

8. Prostaglandin modulation of mast cell-dependent inflammation

   • J. Raud
   • S. -E. Dahlén
   • P. Hedqvist

   Mediators of Hypersensitivity Reactions Pages: 42 - 44

9. Inflammatory mediators andβ-adrenoceptor function

   • J. A. M. Raaijmakers
   • C. Beneker
   • P. Pover

   Mediators of Hypersensitivity Reactions Pages: 45 - 47

10. Analysis of theβ-adrenoceptor mediated inhibition of IgG₁ and IgE dependent guinea-pig anaphylactic tracheal smooth muscle contraction

    • R. G. M. van Amsterdam
    • F. Brouwer
    • J. Zaagsma

    Mediators of Hypersensitivity Reactions Pages: 48 - 51

11. Association between nonspecific bronchial hyperreactivity and superoxide anion production by polymorphonuclear leukocytes in chronic airflow obstruction

    • T. E. J. Renkema
    • D. S. Postma
    • H. F. Kauffman

    Mediators of Hypersensitivity Reactions Pages: 52 - 54

12. β-Adrenergic binding sites and membrane fluidity of guinea pig lymphocytes

    • C. Loesberg
    • M. v. d. Stelt
    • F. P. Nijkamp

    Mediators of Hypersensitivity Reactions Pages: 55 - 56

13. Late asthmatic response to allergen challenge (LAR), its clinical feature and pharmacological modulation

    • Z. Pelikan
    • M. Pelikan-Filipek

    Mediators of Hypersensitivity Reactions Pages: 57 - 58

14. Electrically stimulated Krebs-Henseleit buffer does not relax precontracted human bronchiin vitro

    • R. C. Jongejan
    • J. C. de Jongste
    • K. F. Kerrebijn

    Mediators of Hypersensitivity Reactions Pages: 75 - 76

15. Effect of etoposide and cyclophosphamide on an experimental pulmonary infection in mice

    • W. Calame
    • H. Mattie

    Mediators of Hypersensitivity Reactions Pages: 77 - 78

16. In vivo anaphylaxis in the rat: Effects of phosphodiesterase inhibitors

    • M. J. Post
    • J. D. te Biesebeek
    • A. J. Porsius

    Mediators of Hypersensitivity Reactions Pages: 79 - 81

17. SR2640 (2-[3-(2-quinolylmethoxy) phenylamino]benzoic acid): A novel leukotriene antagonist

    • I. Ahnfelt-Rønne
    • D. Kirstein
    • C. Kærgaard-Nielsen

    Mediators of Hypersensitivity Reactions Pages: 82 - 83

18. Leukotriene release in chopped human lung: Characteristics and regulation

    • M. Kumlin
    • S. -E. Dahlén

    Mediators of Hypersensitivity Reactions Pages: 84 - 86

19. Evidence indicating that leukotrienes C₄, D₄ and E₄ are major mediators of contraction induced by anti-IgE in human bronchi

    • T. Björck
    • S. -E. Dahlén

    Mediators of Hypersensitivity Reactions Pages: 87 - 89

20. Lipoxin A₄ causes generation of thromboxane A₂ in the guinea-pig lung

    • E. Wikström
    • P. Westlund
    • S. -E. Dahlén

    Mediators of Hypersensitivity Reactions Pages: 90 - 92

21. Pharmacodynamics of lipoxin A₄ in airway smooth muscle

    • S. -E. Dahlén
    • C. A. Veale
    • C. N. Serhan

    Mediators of Hypersensitivity Reactions Pages: 93 - 95

22. Leukotriene C₄ formation by purified human eosinophils can be induced by arachidonic acid in the absence of calcium-inophore A23187

    • P. T. M. Kok
    • M. L. Hamelink
    • P. L. B. Bruynzeel

    Mediators of Hypersensitivity Reactions Pages: 96 - 98

23. Arachidonic acid products and the thoracic accumulation of neutrophils and platelets following i.v. antigen challenge of sensitised guinea-pig

    • J. R. Walker
    • S. A. Woodhouse

    Mediators of Hypersensitivity Reactions Pages: 99 - 102

24. Prostaglandin E₂ and salbutamol are less effective in raising cAMP levels of alveolar macrophages from ovalbumin-sensitized guinea-pigs as compared to controls

    • M. Bachelet
    • J. Masliah
    • B. B. Vargaftig

    Mediators of Hypersensitivity Reactions Pages: 103 - 104

25. Regulation of cyclic AMP levels in alveolar macrophages of guinea pigs and man by prostanoids andβ-adrenergic agents

    • F. D. Beusenberg
    • M. J. P. Adolfs
    • I. L. Bonta

    Mediators of Hypersensitivity Reactions Pages: 105 - 107

26. Responses of neutrophilic granulocytesin vitro of asthmatic and healthy subjects and the degree of inhibition by several drugs

    • H. J. Neijens
    • H. C. Raatgeep
    • K. F. Kerrebijn

    Mediators of Hypersensitivity Reactions Pages: 108 - 110

27. Modulation of PAF biosynthesis in human polymorphonuclear leukocytes. The role of phorbol esters and protein kinases

    • M. Sanchez Crespo
    • M. L. Nieto

    Mediators of Hypersensitivity Reactions Pages: 111 - 112

28. Interactions between cyclic AMP stimulating drugs and PAF-acether in guinea-pig alveolar macrophages

    • M. Bachelet
    • M. J. P. Adolfs
    • I. L. Bonta

    Mediators of Hypersensitivity Reactions Pages: 113 - 114

29. The effects of PAF-acether and FMLP on eicosanoid production in guinea pig alveolar macrophages

    • F. J. Zijlstra
    • M. Bachelet
    • J. E. Vincent

    Mediators of Hypersensitivity Reactions Pages: 115 - 116

30. Role of platelet activating factor in the endotoxin induced tracheal hyperreactivity to histamine in the guinea pig

    • F. P. Nijkamp
    • P. Braquet
    • D. van Heuven-Nolsen

    Mediators of Hypersensitivity Reactions Pages: 117 - 118

31. PAF-acether modifies human peritoneal macrophage cAMP levels in a biphasic fashion

    • M. J. P. Adolfs
    • F. D. Beusenberg
    • I. L. Bonta

    Mediators of Hypersensitivity Reactions Pages: 119 - 120

32. Effect of PAF acether on oriented egg phosphatidylcholine multibilayers; interaction with cholesterol; comparison to lyso-PC and lyso-PAF

    • J. L. Olivier
    • C. Chachaty
    • G. Bereziat

    Mediators of Hypersensitivity Reactions Pages: 121 - 122

33. Guinea pig alveolar macrophages possessβ-adrenergic receptors

    • B. van Esch
    • P. A. J. Henricks
    • F. P. Nijkamp

    Mediators of Hypersensitivity Reactions Pages: 123 - 124

34. Effects of topically applied glucocorticosteroids on patch test responses and recruitment of inflammatory cells in allergic contact dermatitis

    • E. P. Prens
    • K. Benne
    • Th. van Joost

    Mediators of Hypersensitivity Reactions Pages: 125 - 127

35. Glucocorticoid receptors in alveolar macrophages: Methodological aspects of the determination of the number of glucocorticoid receptors per cell

    • P. Th. W. van Hal
    • E. Mulder
    • R. Benner

    Mediators of Hypersensitivity Reactions Pages: 128 - 131

36. Macrophages in bronchoalveolar lavage fluid do not represent macrophages in granulomas of the lungs of BCG-infected mice

    • P. H. Nibbering
    • G. A. van de Heide
    • R. van Furth

    Mediators of Hypersensitivity Reactions Pages: 132 - 133

37. Relationship between interleukin 1 (IL1), tumor necrosis factor (TNF) and a neutrophil attracting peptide (NAP-1)

    • J. J. Oppenheim
    • K. Matsushima
    • R. Neta

    Cytokines and Macrophage Activation Pages: 134 - 140

38. Leukotrienes and macrophage activation: Augmented cytotoxic activity and enhanced interleukin 1, tumor necrosis factor and hydrogen peroxide production

    • L. Gagnon
    • L. G. Filion
    • M. Rola-Pleszczynski

    Cytokines and Macrophage Activation Pages: 141 - 147

39. Structure and properties of a novel neutrophil-activating factor (NAF) produced by human monocytes

    • A. Walz
    • P. Peveri
    • M. Baggiolini

    Cytokines and Macrophage Activation Pages: 148 - 150

40. Treatment of colon cancer in rats with rMuTNF and the interferon-inducer bropirimine

    • R. L. Marquet
    • R. W. F. de Bruin
    • J. Jeekel

    Cytokines and Macrophage Activation Pages: 151 - 152

41. Direct effect of murine rIL-1 on cartilage metabolismin vivo

    • A. A. J. van de Loo
    • H. M. van Beuningen
    • W. B. van den Berg

    Cytokines and Macrophage Activation Pages: 153 - 155

42. Potentiation of interleukin-2 release by anti cancer drugs

    • J. L. Turk
    • T. A. Abdul Hamied
    • D. Parker

    Cytokines and Macrophage Activation Pages: 156 - 157

43. Interferon-γ does not enhance the bactericidal activity of murine macrophages

    • R. van Furth
    • J. T. van Dissel

    Cytokines and Macrophage Activation Pages: 158 - 159

44. Effects of disease modifying anti-rheumatic agents on class II antigen expression

    • I. Moodley
    • M. Foster

    Cytokines and Macrophage Activation Pages: 160 - 162

45. Eicosanoids as modulators of macrophage eicosanoid release

    • G. R. Elliott
    • E. J. Schenkelaars
    • I. L. Bonta

    Cytokines and Macrophage Activation Pages: 163 - 164

46. Prostaglandin E₂ and leukotriene C₄ modulate interleukin-1 inhibition of WEHI-3B tumor cell growthin vitro

    • G. R. Elliott
    • C. Tak
    • I. L. Bonta

    Cytokines and Macrophage Activation Pages: 165 - 166

47. Indomethacin stimulation of macrophage cytostasis against MOPC-315 tumor cells is enhanced by endogenous metabolites of lipoxygenase and counteracted by prostaglandin E₂

    • I. L. Bonta
    • G. R. Elliott
    • S. Ben-Efraim

    Cytokines and Macrophage Activation Pages: 167 - 169

48. Endogenous lipoxygenase metabolites mediate A23187 induced macrophage cytostasis towards P815 tumor cellsin vitro

    • J. A. van Hilten
    • G. R. Elliott
    • I. L. Bonta

    Cytokines and Macrophage Activation Pages: 170 - 172

49. Release of PGE₂ and IL-1 as related to suppressive activity of alveolar macrophages from interstitial lung diseases

    • E. Fireman
    • S. Ben-Efraim
    • M. Topilsky

    Cytokines and Macrophage Activation Pages: 173 - 174

50. Regulation of eicosanoid synthesis in mouse peritoneal macrophages by protein kinase C

    • V. Kaever
    • H. -J. Pfannkuche
    • K. Resch

    Cytokines and Macrophage Activation Pages: 175 - 177