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Broadly speaking, the Journal of Pharmacokinetics and Pharmacodynamics covers all areas of pharmacometrics and related disciplines, which includes (population) pharmacokinetics-pharmacodynamics, physiological-based pharmacokinetics (PBPK), systems pharmacology (QSP), and application of machine learning to pharmacokinetics-pharmacodynamics. The journal is devoted to all aspects of pharmacokinetics, pharmacodynamics, and the application of pharmacometrics to drug development and clinical care. The journal publishes on all topics related to pharmacometrics, including, but not limited to, clinical, experimental, and theoretical papers examining the kinetics of drug disposition and effects of drug action; modeling and simulation methodology; PBPK; QSP; precision medicine; and mathematical pharmacology (including computational biology, bioengineering, and biophysics related to pharmacology, pharmacokinetics, or pharmacodynamics). The journal does not strictly publish theoretical manuscripts. Clinical papers that include population pharmacokinetic-pharmacodynamic relationships are welcome, as are population pharmacokinetic papers of novel drugs or analyses with original methodology (without exposure-response analyses). The journal actively invites and promotes up-and-coming areas of pharmacometric research, such as real-world evidence and quality of life analyses. The Journal of Pharmacokinetics and Pharmacodynamics is an official journal of the International Society of Pharmacometrics.

Journal of Pharmacokinetics and Pharmacodynamics publishes six issues a year.

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  • Peter Bonate
Impact factor
2.5 (2022)
5 year impact factor
2.4 (2022)
Submission to first decision (median)
2 days
206,832 (2022)

Latest issue

December 2023 |

Volume 50, Issue 6

Special Issue: Model-Informed Drug Development in Rare Diseases

Latest articles

Journal updates

  • In Memoriam: Hartmut Derendorf

    The journal extends its condolences to the family of Editorial Advisory Board Member Hartmut Derendorf, who unexpectedly passed away on November 23, 2020.  He was a leader in the field and he contributed to the journal as a reviewer and author.  A commentary on his life and legacy was published in March 2021. His obituary can be found here.

  • Journal of Pharmacokinetics and Pharmacodynamics Special Issue on Chronopharmacometrics

    Chronopharmacology is part of pharmacology that is concerned with effects of biological rhythms while pharmacometrics relates to mathematical models of pharmacokinetics and pharmacodynamics of drugs. Chronopharmacometrics encompasses pharmacometric methods relevant to quantifying chronopharmacology and chronotherapeutics. 

    A special issue of Journal of Pharmacokinetics and Pharmacodynamics on Chronopharmacometrics was published in July 2021 presenting state-of-the-art modeling approaches that address the presence of biorhythms in biomarkers used in drug development and therapeutics. Potential topics included but were not limited to:

    • Examples of drugs and biomarkers exhibiting biorhythms: genes, hormones, cells, physiological processes
    • Cosinor analysis and other statistical approaches to detecting and quantifying rhythms in physiological baselines
    • PKPD, PBPK, QSP models of drugs and drug effects with circadian rhythms
    • Mixed effects models of biorhythmic data
    • Time to event analysis of sleep/awake patterns
    • Optimization of dosing regimens for drugs with circadian PKPD
    • Machine learning methods for identification and quantification of biorhythms
    • Real-time data collection of digital data and biorhythms
    • Models of biorhythms in cell cycle
    • Examples of software designed for analysis of biorhythmic data 

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