Predicting monoclonal antibody pharmacokinetics following subcutaneous administration via whole-body physiologically-based modeling Shihao HuDavid Z. D’Argenio Original Paper 04 June 2020 Pages: 385 - 409
Target-mediated exposure enhancement: a previously unexplored limit of TMDD Patrick M. GlassmanVladimir R. Muzykantov Original Paper 02 June 2020 Pages: 411 - 420
A model-based analysis identifies differences in phenotypic resistance between in vitro and in vivo: implications for translational medicine within tuberculosis Oskar CleweAlan FarajUlrika S. H. Simonsson Original Paper Open access 01 June 2020 Pages: 421 - 430
Prior information for population pharmacokinetic and pharmacokinetic/pharmacodynamic analysis: overview and guidance with a focus on the NONMEM PRIOR subroutine Anna H.-X. P. Chan KwongElisa A. M. CalvierSonia Khier Review Paper Open access 13 June 2020 Pages: 431 - 446
PKPD and cardiac single cell modeling of a DDI study with a CYP3A4 substrate and itraconazole to quantify the effects on QT interval duration Felix JaminionDarren BentleyCheikh Diack Original Paper 22 June 2020 Pages: 447 - 459
Performance of longitudinal item response theory models in shortened or partial assessments Leticia ArringtonSebastian UeckertMats O. Karlsson Original Paper Open access 02 July 2020 Pages: 461 - 471
A phase 1 pooled PK/PD analysis of bone resorption biomarkers for odanacatib, a Cathepsin K inhibitor Stefan ZajicS. Aubrey StochJulie A. Stone Original Paper 09 July 2020 Pages: 473 - 484
Comparison of covariate selection methods with correlated covariates: prior information versus data information, or a mixture of both? Estelle ChasseloupGunnar YngmanMats O. Karlsson Original Paper Open access 13 July 2020 Pages: 485 - 492
PBPK modeling of CYP3A and P-gp substrates to predict drug–drug interactions in patients undergoing Roux-en-Y gastric bypass surgery Kuan-Fu ChenLingtak-Neander ChanYvonne S. Lin Original Paper 24 July 2020 Pages: 493 - 512
Use of translational modeling and simulation for quantitative comparison of PF-06804103, a new generation HER2 ADC, with Trastuzumab-DM1 Alison BettsTracey ClarkFrank Barletta Original paper Open access 24 July 2020 Pages: 513 - 526