Editorial to the themed issue on application of pharmacometrics to the development of drugs for rare diseases Peter Bonate Commentary 27 September 2019 Pages: 385 - 386
FDA’s Office of Orphan Products Development: providing incentives to promote the development of products for rare diseases Soumya PatelKatherine I. Miller Needleman Original Paper 05 July 2019 Pages: 387 - 393
Orphan drug development: the increasing role of clinical pharmacology Mariam A. AhmedMalek OkourReena V. Kartha Review Paper 23 July 2019 Pages: 395 - 409
Development and evaluation of a generic population pharmacokinetic model for standard half-life factor VIII for use in dose individualization Alanna McEneny-KingPierre ChelleAndrea N. Edginton Original Paper 18 May 2019 Pages: 411 - 426
Routine clinical care data for population pharmacokinetic modeling: the case for Fanhdi/Alphanate in hemophilia A patients Pierre ChelleCindy H. T. YeungAndrea Edginton Original Paper Open access 21 May 2019 Pages: 427 - 438
Correction to: Routine clinical care data for population pharmacokinetic modeling: the case for Fanhdi/Alphanate in hemophilia A patients Pierre ChelleCindy H. T. YeungAndrea Edginton Correction Open access 13 July 2019 Pages: 439 - 439
Towards regulatory endorsement of drug development tools to promote the application of model-informed drug development in Duchenne muscular dystrophy Daniela J. ConradoJane Larkindalethe Duchenne Muscular Dystrophy Regulatory Science Consortium (D-RSC) Original Paper 24 May 2019 Pages: 441 - 455
A physiologically-motivated model of cystic fibrosis liquid and solute transport dynamics across primary human nasal epithelia Florencio Serrano CastilloCarol A. BertrandRobert S. Parker OriginalPaper 07 September 2019 Pages: 457 - 472
Modeling and simulation of the modified Rankin Scale and National Institutes of Health Stroke Scale neurological endpoints in intracerebral hemorrhage Rik SchoemakerSatyaprakash NayakVISTA-ICH Collaboration Original Paper 29 August 2019 Pages: 473 - 484
A quantitative systems pharmacology model of colonic motility with applications in drug development Raibatak DasLucia WilleMajid Vakilynejad Original Paper 20 August 2019 Pages: 485 - 498
A modeling and simulation-based assessment of the impact of confounding factors on the readout of a sildenafil survival trial in pulmonary arterial hypertension Pascal ChanuXiang GaoLutz Harnisch Original Paper 20 September 2019 Pages: 499 - 509