A comprehensive evaluation of exposure–response relationships in clinical trials: application to support guselkumab dose selection for patients with psoriasis Chuanpu HuZhenling YaoHonghui Zhou Original Paper 16 March 2018 Pages: 523 - 535
Model reduction in mathematical pharmacology Thomas J. SnowdenPiet H. van der GraafMarcus J. Tindall Original Paper Open access 26 March 2018 Pages: 537 - 555
Receptor/gene/protein-mediated signaling connects methylprednisolone exposure to metabolic and immune-related pharmacodynamic actions in liver Vivaswath S. AyyarSiddharth SukumaranWilliam J. Jusko Original Paper 27 April 2018 Pages: 557 - 575
Physiologically-based modeling and interspecies prediction of paclitaxel pharmacokinetics Xiaowei ZangLeonid Kagan Original Paper 18 April 2018 Pages: 577 - 592
Projected 24-hour post-dose ocular itching scores post-treatment with olopatadine 0.7% versus 0.2% Matthew L. FidlerAbayomi OgundeleRamesh Sarangapani Original Paper Open access 21 April 2018 Pages: 593 - 605
Multiscale systems pharmacological analysis of everolimus action in hepatocellular carcinoma Anusha AndeMaher ChaarSihem Ait-Oudhia Original Paper 03 May 2018 Pages: 607 - 620
Modelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment models Wilhelmus E. A. de WitteVivi RottschäferElizabeth C. M. de Lange Original Paper Open access 18 May 2018 Pages: 621 - 635
Reduced and optimized trial designs for drugs described by a target mediated drug disposition model A. BrekkanS. JönssonA. C. Hooker Original Paper Open access 08 June 2018 Pages: 637 - 647
Modeling and simulations to support dose selection for eslicarbazepine acetate therapy in pediatric patients with partial-onset seizures Soujanya SunkaraneniElizabeth LudwigDavid Blum Original Paper Open access 09 June 2018 Pages: 649 - 658
