1. Editorial

   • Malcolm Rowland
   • Thomas M. Ludden

   Editorial Commentary Pages: 1 - 1

2. Endothelial Binding of Recombinant Tissue Plasminogen Activator: Quantification In Vivo Using a Recirculatory Model

   • Michiel J. B. Kemme
   • Rik C. Schoemaker
   • Adam F. Cohen

   OriginalPaper Pages: 3 - 22

3. Competition Between Acetylcholine and a Nondepolarizing Muscle Relaxant for Binding to the Postsynaptic Receptors at the Motor End Plate: Simulation of Twitch Strength and Neuromuscular Block

   • Vladimir Nigrovic
   • Anton Amann

   OriginalPaper Pages: 23 - 51

4. Estimation of Population Pharmacokinetic Parameters in the Presence of Non-compliance

   • Song Mu
   • Thomas M. Ludden

   OriginalPaper Pages: 53 - 81

5. A Joint Model for Nonlinear Longitudinal Data with Informative Dropout

   • Chuanpu Hu
   • Mark E. Sale

   OriginalPaper Pages: 83 - 103