1. Editorial

   • Martine Clozel

   Editorial Introduction Pages: 249 - 251

2. Therapeutic Role of Bosentan in Hypertension: Lessons from the Model of Perinephritic Hypertension

   • Julian E. Donckier

   OriginalPaper Pages: 253 - 264

3. Crosstalk Between Endothelin and Nitric Oxide in the Control of Vascular Tone

   • Michel Lavallée
   • Masayuki Takamura
   • Eric Thorin

   OriginalPaper Pages: 265 - 276

4. Role of Endothelin in the Control of Peripheral Vascular Tone in Human Hypertension

   • Stefano Taddei
   • Agostino Virdis
   • Antonio Salvetti

   OriginalPaper Pages: 277 - 285

5. Potential Role of Endothelin Receptor Antagonists in the Setting of Cardiopulmonary Bypass: Relevance to Myocardial Performance

   • Adviye Ergul
   • Cassandra Joffs
   • Francis G. Spinale

   OriginalPaper Pages: 287 - 294

6. Endothelin Antagonism in Experimental Ischemic Heart Failure: Hemodynamic, Structural and Neurohumoral Effects

   • Paul Mulder
   • Vincent Richard
   • Christian Thuillez

   OriginalPaper Pages: 295 - 300

7. Endothelin A Receptor Antagonists in Congestive Heart Failure: Blocking the Beast while Leaving the Beauty Untouched?

   • Lukas E. Spieker
   • Georg Noll
   • Thomas F. Lu¨scher

   OriginalPaper Pages: 301 - 315

8. Clinical Experience with Endothelin Receptor Antagonists in Chronic Heart Failure

   • Alison Seed
   • Michael P. Love
   • John J.V. McMurray

   OriginalPaper Pages: 317 - 323

9. Hemodynamic Effects of Bosentan in Patients with Chronic Heart Failure

   • W. Kiowski
   • G. Su¨tsch
   • O. Bertel

   OriginalPaper Pages: 325 - 334

10. Endothelin and Heart Failure

    • Ponnal Nambi
    • Martine Clozel
    • Giora Feuerstein

    OriginalPaper Pages: 335 - 340

11. Diagnostic and Therapeutic Potential of the Endothelin System in Patients with Chronic Heart Failure

    • Henry Krum
    • Rachel Denver
    • Paul Martin

    OriginalPaper Pages: 341 - 352