1. Introduction: Role of Modeling and Simulation in Clinical Development of Anticancer Agents

   • Alex Sparreboom
   • Mats O. Karlsson

   OriginalPaper Pages: 139 - 140

2. Toxicity Patterns of Cytotoxic Drugs

   • Etienne Chatelut
   • Jean-Pierre Delord
   • Pierre Canal

   OriginalPaper Pages: 141 - 148

3. Chemotherapy Individualization

   • Gareth J. Veal
   • Sally A. Coulthard
   • Alan V. Boddy

   OriginalPaper Pages: 149 - 156

4. Noninvasive Methods to Study Drug Distribution

   • Ruediger E. Port
   • Walter Wolf

   OriginalPaper Pages: 157 - 168

5. Use of Positron Emission Tomography in Anticancer Drug Development

   • Eric O. Aboagye
   • Patricia M. Price

   OriginalPaper Pages: 169 - 181

6. Mechanistic Models for Myelosuppression

   • Lena E. Friberg
   • Mats O. Karlsson

   OriginalPaper Pages: 183 - 194

7. Clinical Pharmacokinetic/Pharmacodynamic and Physiologically based Pharmacokinetic Modeling in New Drug Development: The Capecitabine Experience

   • Karen S. Blesch
   • Ronald Gieschke
   • Jean-Louis Steimer

   OriginalPaper Pages: 195 - 223

8. Pharmacokinetic–pharmacodynamic Guided Trial Design in Oncology

   • Ch. van Kesteren
   • R.A.A. Mathôt
   • J.H.M. Schellens

   OriginalPaper Pages: 225 - 241

9. Clinical Trial Design for Target Specific Anticancer Agents

   • Ronald Hoekstra
   • Jaap Verweij
   • Ferry A.L.M. Eskens

   OriginalPaper Pages: 243 - 250