1. Introduction

   • Martin Clynes

   EditorialNotes Pages: vii - viii

2. P-glycoprotein structure and evolutionary homologies

   • James M. Croop

   OriginalPaper Pages: 1 - 32

3. Molecular analysis of the multidrug transporter

   • Ursula A. Germann

   OriginalPaper Pages: 33 - 62

4. Molecular cytogenetics of multiple drug resistance

   • Patricia V. Schoenlein

   OriginalPaper Pages: 63 - 89

5. Antibodies in the study of multiple drug resistance

   • Yuji Heike
   • Takashi Tsuruo

   OriginalPaper Pages: 91 - 107

6. Non-P-glycoprotein multidrug resistance in cell lines which are defective in the cellular accumulation of drug

   • Melvin S. Center

   OriginalPaper Pages: 109 - 125

7. Topoisomerase I in multiple drug resistance

   • Augusto Pessina

   OriginalPaper Pages: 127 - 135

8. Topoisomerase II in multiple drug resistance

   • Glenn A. Hofmann
   • Michael R. Mattern

   OriginalPaper Pages: 137 - 154

9. Glutathione-related enzymes, glutathione and multidrug resistance

   • Jeffrey A. Moscow
   • Katharine H. Dixon

   OriginalPaper Pages: 155 - 170

10. Pharmacologic circumvention of multidrug resistance

    • James M. Ford
    • William N. Hait

    OriginalPaper Pages: 171 - 212

11. Multidrug resistance (MDR) genes in haematological malignancies

    • K. Nooter
    • P. Sonneveld

    OriginalPaper Pages: 213 - 230

12. Human cell lines as models for multidrug resistance in solid tumours

    • Martin Clynes
    • Mary Heenan
    • Keara Hall

    OriginalPaper Pages: 231 - 256

13. Studies on low-level MDR cells

    • G. Belvedere
    • E. Dolfini

    OriginalPaper Pages: 257 - 264

14. Differing patterns of cross-resistance resulting from exposures to specific antitumour drugs or to radiationin vitro

    • Bridget T. Hill

    OriginalPaper Pages: 265 - 288

15. The use of reverse transcriptase-polymerase chain reaction (RT-PCR) to investigate specific gene expression in multidrug-resistant cells

    • Lorraine O'Driscoll
    • Carmel Daly
    • Martin Clynes

    OriginalPaper Pages: 289 - 314

16. Mathematical models for multidrug resistance and its reversal

    • Seth Michelson

    OriginalPaper Pages: 315 - 324

17. The biology of radioresistance: similarities, differences and interactions with drug resistance

    • Simon N. Powell
    • Edward H. Abraham

    OriginalPaper Pages: 325 - 345

18. Kinetic resistance to anticancer agents

    • Marie-Thérèse Dimanche-Boitrel
    • Carmen Garrido
    • Bruno Chauffert

    OriginalPaper Pages: 347 - 356

19. Cytochromes P450 and drug resistance

    • Johannes Doehmer
    • Arnold R. Goeptar
    • Nico P. E. Vermeulen

    OriginalPaper Pages: 357 - 366

20. Role of matrix metalloproteinases in invasion, and metastasis: biology, diagnosis and inhibitors

    • Susan McDonnell
    • Barbara Fingleton

    OriginalPaper Pages: 367 - 384

21. Clinical significance of cellular resistance in tumours to cytotoxic chemotherapy and radiotherapy

    • Maeve Pomeroy
    • Michael Moriarty

    OriginalPaper Pages: 385 - 391