1. Welcome to our regional editors

   • Lionel H. Opie
   • Elliot Rapaport

   EditorialNotes Pages: 5 - 5

2. The captopril-digoxin multicenter resarch group study on the comparative steps of captopril and digoxin in patients with mildmoderate heart failure: Implications for therapy

   • Bertram Pitt
   • Sidney Goldstein

   Focused Section on Digoxin Pages: 7 - 9

3. Digoxin revived?

   • Lionel H. Opie

   Focused Section on Digoxin Pages: 11 - 12

4. The rationale for combined use of diuretics, digitalis, and vasodilators in congestive heart failure

   • Thomas W. Smith
   • Marc A. Pfeffer

   Focused Section on Digoxin Pages: 13 - 17

5. An explanation for varying views about digitalis efficacy in congestive heart failure

   • Jay N. Cohn

   Focused Section on Digoxin Pages: 19 - 20

6. Does digoxin have a place in the treatment of the child with congenital heart disease?

   • Andrew N. Redington
   • Julene S. Carvalho
   • Elliot A. Shinebourne

   Focused Section on Digoxin Pages: 21 - 24

7. The digoxin-amiodarone interaction

   • Killian Robinson
   • Atholl Johnston
   • David W. Holt

   Focused Section on Digoxin Pages: 25 - 28

8. New mechanisms for positive inotropic agents: Focus on the discovery and development of imazodan

   • Ronald E. Weishaar
   • Dianne Kobylarz-Singer
   • Beth A. Klinkefus

   New Cardiovascular Drug Section Pages: 29 - 42

9. Pharmacological mechanisms to attenuate sympathetically induced myocardial ischemia

   • Rainer Schulz
   • Brian D. Guth
   • Gerd Heusch

   Reviews Pages: 43 - 56

10. Fosenopril, an angiotensin-converting enzyme inhibitor, and propranolol: Comparative effects at rest and exercise on blood pressure, hormonal variables, and plasma potassium in essential hypertension

    • Patrick A Sullivan
    • Justine Cervenka
    • Mary Dineen

    Clinical Studies Pages: 57 - 62

11. Effect of beta-adrenergic blockade on hormonal responses during continuous and intermittent exercise

    • Lars Gullestad
    • Lars Oystein Dolva
    • John Kjekshus

    Clinical Studies Pages: 63 - 71

12. Diprafenone for treatment of Wolff-Parkinson-White syndrome

    • Klaus Peter Kunze
    • Michael Schlüter
    • Karl-Heinz Kuck

    Clinical Studies Pages: 73 - 79

13. Coronary vasodilator and cardiac effects of NKY-722, a novel hydrophilic 1,4-dihydropyridine derivative, in the blood-perfused dog heart

    • Jun-ichi Imagawa
    • Keisuke Satoh
    • Norio Taira

    Experimental Studies Pages: 81 - 90

14. Myocardial, coronary, and peripheral effects of xamoterol (ICI 118,587) in open-chest pigs

    • Nazzareno Galiè
    • Mauro Metalli
    • Bruno Magnani

    Experimental Studies Pages: 91 - 97