1. Editors farewell

   EditorialNotes Pages: iii - iii

2. Announcement

   Announcement Pages: iv - iv

3. Human melanoma: Development and progression

   • Meenhard Herlyn

   OriginalPaper Pages: 101 - 112

4. Cell-matrix interactions during tumor invasion

   • Jean R. Starkey

   OriginalPaper Pages: 113 - 123

5. Spontaneous tumors in dogs and cats: Models for the study of cancer biology and treatment

   • E. Gregory MacEwen

   OriginalPaper Pages: 125 - 136

6. Tumor progression: Potential role of unstable genomic changes

   • R. P. Hill

   OriginalPaper Pages: 137 - 147

7. Orthotopic implantation is essential for the selection, growth and metastasis of human real cell cancer in nude mice

   • Isaiah J. Fidler
   • Seiji Naito
   • Sen Pathak

   OriginalPaper Pages: 149 - 165