Volume 46, Issue 3-4

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March 2019

Special Issue: Natural Product Discovery and Development in the Genomic Era - 2019

Issue Editors:

Richard H. Baltz,
Ikuro Abe,
Eung Soo Kim,
Rolf Müller,
Steven G. Van Lanen,
Gerry Wright

26 articles in this issue

Introduction to the special issue: “Natural Product Discovery and Development in the Genomic Era: 2019”
Richard H. Baltz
Ikuro Abe
Gerry Wright
Editorial 07 February 2019 Pages: 249 - 249
Dedication: Heinz Floss and Christopher Walsh—pioneers in natural product chemical biology
Rolf Müller
Gerard D. Wright
Editorial 07 February 2019 Pages: 251 - 255
Emerging evolutionary paradigms in antibiotic discovery
Marc G. Chevrette
Cameron R. Currie
Natural Products - Original Paper 29 September 2018 Pages: 257 - 271
New voyages to explore the natural product galaxy
Nigel J. Mouncey
Hiroshi Otani
Yasuo Yoshikuni
Natural Products - Original Paper 04 January 2019 Pages: 273 - 279
Natural product drug discovery in the genomic era: realities, conjectures, misconceptions, and opportunities
Richard H. Baltz
Natural Products - Original Paper 27 November 2018 Pages: 281 - 299
Toward a global picture of bacterial secondary metabolism
Mohammad R. Seyedsayamdost
Natural Products - Original Paper 25 January 2019 Pages: 301 - 311
A3 foresight network on natural products
Linquan Bai
Yasuo Ohnishi
Eung-Soo Kim
Natural Products - Original Paper 24 November 2018 Pages: 313 - 317
Genome mining reveals uncommon alkylpyrones as type III PKS products from myxobacteria
Joachim J. Hug
Fabian Panter
Rolf Müller
Natural Products - Original Paper 01 December 2018 Pages: 319 - 334
Discovery, properties, and biosynthesis of pseudouridimycin, an antibacterial nucleoside-analog inhibitor of bacterial RNA polymerase
Sonia I. Maffioli
Margherita Sosio
Stefano Donadio
Natural Products - Original Paper 21 November 2018 Pages: 335 - 343
A selective genome-guided method for environmental Burkholderia isolation
F. P. Jake Haeckl
João L. Baldim
Roger G. Linington
Natural Products - Original Paper 24 January 2019 Pages: 345 - 362
Activation of silent biosynthetic pathways and discovery of novel secondary metabolites in actinomycetes by co-culture with mycolic acid-containing bacteria
Shotaro Hoshino
Hiroyasu Onaka
Ikuro Abe
Natural Products - Mini Review 28 November 2018 Pages: 363 - 374
Natural products from anaerobes
Jeffrey S. Li
Colin Charles Barber
Wenjun Zhang
Natural Products - Original Paper 03 October 2018 Pages: 375 - 383
Bioactive molecules from Nocardia: diversity, bioactivities and biosynthesis
Dipesh Dhakal
Vijay Rayamajhi
Jae Kyung Sohng
Metabolic Engineering and Synthetic Biology - Original Paper 18 January 2019 Pages: 385 - 407
Searching for potent and specific antibiotics against pathogenic Helicobacter and Campylobacter strains
Yasushi Ogasawara
Tohru Dairi
Natural Products - Original Paper 20 November 2018 Pages: 409 - 414
Heterologous expression-facilitated natural products’ discovery in actinomycetes
Min Xu
Gerard D. Wright
Natural Products - Original Paper 16 November 2018 Pages: 415 - 431
Challenges and opportunities for natural product discovery, production, and engineering in native producers versus heterologous hosts
Christiana N. Teijaro
Ajeeth Adhikari
Ben Shen
Natural Products - Original Paper 13 November 2018 Pages: 433 - 444
Recent advances in the discovery and combinatorial biosynthesis of microbial 14-membered macrolides and macrolactones
Je Won Park
Yeo Joon Yoon
Metabolic Engineering and Synthetic Biology - Original Paper 10 November 2018 Pages: 445 - 458
Discovery of caerulomycin/collismycin-type 2,2′-bipyridine natural products in the genomic era
Dandan Chen
Qunfei Zhao
Wen Liu
Natural Products - Mini Review 27 November 2018 Pages: 459 - 468
Sequence-based classification of type II polyketide synthase biosynthetic gene clusters for antiSMASH
Rasmus Villebro
Simon Shaw
Tilmann Weber
Natural Products - Original Paper 04 January 2019 Pages: 469 - 475
Efficient transposition of Tn4556 by alterations in inverted repeats using a delivery vector carrying a counter-selectable marker for Streptomyces
Masahiro Sota
Akiko Sakoda
Haruo Ikeda
Genetics and Molecular Biology of Industrial Organisms - Short Communication Open access 20 November 2018 Pages: 477 - 482
Discovery of novel glycerolated quinazolinones from Streptomyces sp. MBT27
Nataliia V. Machushynets
Changsheng Wu
Gilles P. van Wezel
Natural Products - Original Paper Open access 07 February 2019 Pages: 483 - 492
Refining and expanding nonribosomal peptide synthetase function and mechanism
Matt McErlean
Jonathan Overbay
Steven Van Lanen
Natural Products - Original Paper 23 January 2019 Pages: 493 - 513
Structural basis of the nonribosomal codes for nonproteinogenic amino acid selective adenylation enzymes in the biosynthesis of natural products
Fumitaka Kudo
Akimasa Miyanaga
Tadashi Eguchi
Natural Products - Original Paper 05 October 2018 Pages: 515 - 536
CylA is a sequence-specific protease involved in toxin biosynthesis
Weixin Tang
Silvia C. Bobeica
Wilfred A. van der Donk
Natural Products - Original Paper 27 November 2018 Pages: 537 - 549
Investigations into PoyH, a promiscuous protease from polytheonamide biosynthesis
Maximilian J. Helf
Michael F. Freeman
Jörn Piel
Natural Products - Original Paper 09 January 2019 Pages: 551 - 563
Fabclavine biosynthesis in X. szentirmaii: shortened derivatives and characterization of the thioester reductase FclG and the condensation domain-like protein FclL
Sebastian L. Wenski
Diana Kolbert
Helge B. Bode
Natural Products - Original Paper 04 January 2019 Pages: 565 - 572

Volume 46, Issue 3-4

Introduction to the special issue: “Natural Product Discovery and Development in the Genomic Era: 2019”

Dedication: Heinz Floss and Christopher Walsh—pioneers in natural product chemical biology

Emerging evolutionary paradigms in antibiotic discovery

New voyages to explore the natural product galaxy

Natural product drug discovery in the genomic era: realities, conjectures, misconceptions, and opportunities

Toward a global picture of bacterial secondary metabolism

A3 foresight network on natural products

Genome mining reveals uncommon alkylpyrones as type III PKS products from myxobacteria

Discovery, properties, and biosynthesis of pseudouridimycin, an antibacterial nucleoside-analog inhibitor of bacterial RNA polymerase

A selective genome-guided method for environmental Burkholderia isolation

Activation of silent biosynthetic pathways and discovery of novel secondary metabolites in actinomycetes by co-culture with mycolic acid-containing bacteria

Natural products from anaerobes

Bioactive molecules from Nocardia: diversity, bioactivities and biosynthesis

Searching for potent and specific antibiotics against pathogenic Helicobacter and Campylobacter strains

Heterologous expression-facilitated natural products’ discovery in actinomycetes

Challenges and opportunities for natural product discovery, production, and engineering in native producers versus heterologous hosts

Recent advances in the discovery and combinatorial biosynthesis of microbial 14-membered macrolides and macrolactones

Discovery of caerulomycin/collismycin-type 2,2′-bipyridine natural products in the genomic era

Sequence-based classification of type II polyketide synthase biosynthetic gene clusters for antiSMASH

Efficient transposition of Tn4556 by alterations in inverted repeats using a delivery vector carrying a counter-selectable marker for Streptomyces

Discovery of novel glycerolated quinazolinones from Streptomyces sp. MBT27

Refining and expanding nonribosomal peptide synthetase function and mechanism

Structural basis of the nonribosomal codes for nonproteinogenic amino acid selective adenylation enzymes in the biosynthesis of natural products

CylA is a sequence-specific protease involved in toxin biosynthesis

Investigations into PoyH, a promiscuous protease from polytheonamide biosynthesis

Fabclavine biosynthesis in X. szentirmaii: shortened derivatives and characterization of the thioester reductase FclG and the condensation domain-like protein FclL

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