Volume 43, Issue 2-3

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March 2016

Special Issue: Natural Product Discovery and Development in the Genomic Era

Issue Editors:

Richard Baltz,
Haruo Ikeda,
Leonard Katz,
Eung Soo Kim,
Gilles van Wezel,
Gerry Wright

26 articles in this issue

Introduction to the Special Issue: “Natural Product Discovery and Development in the Genomic Era”
Richard H. Baltz
Haruo Ikeda
Gerry Wright
Editorial 11 December 2015 Pages: 109 - 109
Satoshi Ōmura
David A. Hopwood
Natural Products 18 July 2015 Pages: 111 - 113
Leveraging ecological theory to guide natural product discovery
Michael J. Smanski
Daniel C. Schlatter
Linda L. Kinkel
Natural Products 05 October 2015 Pages: 115 - 128
Culture-independent discovery of natural products from soil metagenomes
Micah Katz
Bradley M. Hover
Sean F. Brady
Natural Products 19 November 2015 Pages: 129 - 141
Streptomyces metabolites in divergent microbial interactions
Hideaki Takano
Tatsuya Nishiyama
Kenji Ueda
Environmental Microbiology 25 September 2015 Pages: 143 - 148
Antibiotics and evolution: food for thought
C. R. Strachan
J. Davies
Natural Products 02 November 2015 Pages: 149 - 153
Natural product discovery: past, present, and future
Leonard Katz
Richard H. Baltz
Review 06 January 2016 Pages: 155 - 176
Advancing cell wall inhibitors towards clinical applications
Sonia I. Maffioli
João C. S. Cruz
Stefano Donadio
Natural Products 29 October 2015 Pages: 177 - 184
Natural product derived insecticides: discovery and development of spinetoram
Ute Galm
Thomas C. Sparks
Natural Products 18 November 2015 Pages: 185 - 193
Discovery and development of surotomycin for the treatment of Clostridium difficile
Victoria Knight-Connoni
Carmela Mascio
Jared Silverman
Review 15 December 2015 Pages: 195 - 204
Anti-tuberculosis lead molecules from natural products targeting Mycobacterium tuberculosis ClpC1
Hanki Lee
Joo-Won Suh
Mini-Review 19 November 2015 Pages: 205 - 212
Chemistry and biology of the compounds that modulate cell migration
Etsu Tashiro
Masaya Imoto
Mini-Review 15 July 2015 Pages: 213 - 219
Discovery of novel drug targets and their functions using phenotypic screening of natural products
Junghwa Chang
Ho Jeong Kwon
Natural Products 12 September 2015 Pages: 221 - 231
David and Goliath: chemical perturbation of eukaryotes by bacteria
Louis K. Ho
Justin R. Nodwell
Review Open access 03 October 2015 Pages: 233 - 248
Natural products as probes in pharmaceutical research
Esther K. Schmitt
D. Hoepfner
P. Krastel
Review 05 October 2015 Pages: 249 - 260
Genome neighborhood network reveals insights into enediyne biosynthesis and facilitates prediction and prioritization for discovery
Jeffrey D. Rudolf
Xiaohui Yan
Ben Shen
Natural Products 29 August 2015 Pages: 261 - 276
Identification and activation of novel biosynthetic gene clusters by genome mining in the kirromycin producer Streptomyces collinus Tü 365
Dumitrita Iftime
Andreas Kulik
Wolfgang Wohlleben
Natural Products 03 October 2015 Pages: 277 - 291
Informatic search strategies to discover analogues and variants of natural product archetypes
Chad W. Johnston
Alex D. Connaty
Nathan A. Magarvey
Biotechnology Methods 08 September 2015 Pages: 293 - 298
Metabolic profiling as a tool for prioritizing antimicrobial compounds
Changsheng Wu
Young Hae Choi
Gilles P. van Wezel
Natural Products Open access 03 September 2015 Pages: 299 - 312
Integrating mass spectrometry and genomics for cyanobacterial metabolite discovery
Nathan A. Moss
Matthew J. Bertin
William H. Gerwick
Natural Products 17 November 2015 Pages: 313 - 324
Biosynthesis of mercapturic acid derivative of the labdane-type diterpene, cyslabdan that potentiates imipenem activity against methicillin-resistant Staphylococcus aureus: cyslabdan is generated by mycothiol-mediated xenobiotic detoxification
Haruo Ikeda
Kazuo Shin-ya
Hiroshi Tomoda
Genetics and Molecular Biology of Industrial Organisms 27 October 2015 Pages: 325 - 342
Genetic manipulation of secondary metabolite biosynthesis for improved production in Streptomyces and other actinomycetes
Richard H. Baltz
Natural Products 12 September 2015 Pages: 343 - 370
Harnessing natural product assembly lines: structure, promiscuity, and engineering
Christopher C. Ladner
Gavin J. Williams
Metabolic Engineering and Synthetic Biology 02 November 2015 Pages: 371 - 387
The biosynthetic pathway of FK506 and its engineering: from past achievements to future prospects
Yeon Hee Ban
Sung Ryeol Park
Yeo Joon Yoon
Genetics and Molecular Biology of Industrial Organisms 05 September 2015 Pages: 389 - 400
Natural and engineered biosynthesis of nucleoside antibiotics in Actinomycetes
Wenqing Chen
Jianzhao Qi
Zixin Deng
Review 08 July 2015 Pages: 401 - 417
The many roles of glutamate in metabolism
Mark C. Walker
Wilfred A. van der Donk
Mini-Review 01 September 2015 Pages: 419 - 430

Volume 43, Issue 2-3

Introduction to the Special Issue: “Natural Product Discovery and Development in the Genomic Era”

Satoshi Ōmura

Leveraging ecological theory to guide natural product discovery

Culture-independent discovery of natural products from soil metagenomes

Streptomyces metabolites in divergent microbial interactions

Antibiotics and evolution: food for thought

Natural product discovery: past, present, and future

Advancing cell wall inhibitors towards clinical applications

Natural product derived insecticides: discovery and development of spinetoram

Discovery and development of surotomycin for the treatment of Clostridium difficile

Anti-tuberculosis lead molecules from natural products targeting Mycobacterium tuberculosis ClpC1

Chemistry and biology of the compounds that modulate cell migration

Discovery of novel drug targets and their functions using phenotypic screening of natural products

David and Goliath: chemical perturbation of eukaryotes by bacteria

Natural products as probes in pharmaceutical research

Genome neighborhood network reveals insights into enediyne biosynthesis and facilitates prediction and prioritization for discovery

Identification and activation of novel biosynthetic gene clusters by genome mining in the kirromycin producer Streptomyces collinus Tü 365

Informatic search strategies to discover analogues and variants of natural product archetypes

Metabolic profiling as a tool for prioritizing antimicrobial compounds

Integrating mass spectrometry and genomics for cyanobacterial metabolite discovery

Biosynthesis of mercapturic acid derivative of the labdane-type diterpene, cyslabdan that potentiates imipenem activity against methicillin-resistant Staphylococcus aureus: cyslabdan is generated by mycothiol-mediated xenobiotic detoxification

Genetic manipulation of secondary metabolite biosynthesis for improved production in Streptomyces and other actinomycetes

Harnessing natural product assembly lines: structure, promiscuity, and engineering

The biosynthetic pathway of FK506 and its engineering: from past achievements to future prospects

Natural and engineered biosynthesis of nucleoside antibiotics in Actinomycetes

The many roles of glutamate in metabolism

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