1. Challenges and progress in the treatment of infections

   • H. J. Neijens
   • I. A. J. M. Bakker-Woudenberg
   • J. W. M. van der Meer

   Introduction Pages: S1 - S1

2. Relevance of antibiotic susceptibility testing for clinical practice

   • L. Verbist

   Failure of Antimicrobial Treatment—The Microorganism Pages: S2 - S5

3. Pharmacodynamics of antimicrobial agents as a Basis for Determining Dosage Regimens

   • W. Craig

   Failure of Antimicrobial Treatment—The Microorganism Pages: S6 - S8

4. Basic mechanisms of bacterial tolerance of antimicrobial agents

   • W. H. F. Goessens

   Failure of Antimicrobial Treatment—The Microorganism Pages: S9 - S12

5. Genetic control of population structure in heterogeneous strains of methicillin resistantStaphylococcus aureus

   • H. de Lencastre
   • A. M. S. Figueiredo
   • A. Tomasz

   Failure of Antimicrobial Treatment—The Microorganism Pages: S13 - S18

6. Importance of beta-lactamase induction

   • I. Phillips
   • K. Shannon

   Failure of Antimicrobial Treatment—The Microorganism Pages: S19 - S26

7. The threat of multiresistant microorganisms

   • C. M. J. E. Vandenbroucke-Grauls

   Failure of Antimicrobial Treatment—The Microorganism Pages: S27 - S30

8. Anatomical barriers for antimicrobial agents

   • M. Barza

   Failure of Antimicrobial Treatment—The Host Pages: S31 - S35

9. Diseases and drug-related interventions affecting host defence

   • S. de Marie

   Failure of Antimicrobial Treatment—The Host Pages: S36 - S41

10. Fungal and bacterial infections in the immunocompromised host

    • R. H. Rubin

    Failure of Antimicrobial Treatment—The Host Pages: 42 - S48

11. The value of new antimicrobial agents

    • J. H. T. Wagenvoort

    New Approaches—Antimicrobial Agents Pages: S49 - S54

12. Relevance of animal models for clinical treatment

    • W. Craig

    New Approaches—Antimicrobial Agents Pages: S55 - S57

13. Abnormal pharmacokinetics: the need for monitoring

    • A. M. Horrevorts
    • J. W. Mouton

    New Approaches—Antimicrobial Agents Pages: S58 - S60

14. Liposomes as carriers of antimicrobial agents or immunomodulatory agents in the treatment of infections

    • I. A. J. M. Bakker-Woudenberg
    • A. F. Lokerse
    • E. W. M. van Etten

    New Approaches—Antimicrobial Agents Pages: S61 - S67

15. Role of glucocorticosteroids in the treatment of infectious diseases

    • J. Thompson

    New Approaches—Immunostimulation Pages: S68 - S72

16. Interleukin-1 as a possible agent for treatment of infection

    • J. W. M. van der Meer
    • M. Vogels
    • W. M. C. Eling

    New Approaches—Immunostimulation Pages: S73 - S77